Flat top beam profile cavity prototype

Author(s):  
J. Agresti ◽  
E. D'Ambrosio ◽  
R. DeSalvo ◽  
J. Mackowski ◽  
A. Remillieux ◽  
...  
Keyword(s):  
1997 ◽  
Vol 29 (2) ◽  
pp. 57-61 ◽  
Author(s):  
W.C. Yen ◽  
C.T. Huang ◽  
H.P. Liu ◽  
L.P. Lee
Keyword(s):  

2019 ◽  
Vol 44 (17) ◽  
pp. 4428
Author(s):  
A. López-Vázquez ◽  
Y. M. Torres ◽  
M. S. Billión ◽  
W. M. Pimenta ◽  
J. A. Franco-Villafañe ◽  
...  

2021 ◽  
Vol 22 (15) ◽  
pp. 7788
Author(s):  
Andrea Amaroli ◽  
Praveen Arany ◽  
Claudio Pasquale ◽  
Stefano Benedicenti ◽  
Alessandro Bosco ◽  
...  

The tremendous therapeutic potential of photobiomodulation therapy in different branches of medicine has been described in the literature. One of the molecular mechanisms for this treatment implicates the mitochondrial enzyme, cytochrome C oxidase. However, the efficacy and consistency of clinical outcomes with photobiomodulation treatments has been fiercely debated. This work was motivated by this need to improve photobiomodulation devices and delivery approaches. We designed a novel hand-piece with a flat-top beam profile of irradiation. We compared the beam profile versus a standard hand-piece and a fibre probe. We utilized isolated mitochondria and performed treatments at various spots within the beam, namely, the centre, left and right edge. We examined mitochondrial activity by assessing ATP synthesis with the luciferin/luciferase chemiluminescent method as a primary endpoint, while mitochondrial damage was assessed as the secondary endpoint. We observed a uniform distribution of the power density with the flat-top prototype compared to a wide Gaussian beam profile with the standard fibre and standard hand-piece. We noted increased production of ATP in the centre of all three beams with respect to the non-treated controls (p < 0.05). Both the fibre and standard hand-piece demonstrated less increase in ATP synthesis at the edges than the centre (p < 0.05). In contrast, ATP synthesis was increased homogenously in the flat-top handpiece, both in the centre and the edges of the beam. Fibre, standard hand-piece and the flat-top hand-piece prototype have discrete beam distribution characteristics. This significantly affected the mitochondrial activity with respect to their position within the treated areas. Flat-top hand-piece enhances the uniformity of photobiomodulation treatments and can improve the rigour and reproducibility of PBM clinical outcomes.


2011 ◽  
Vol 284 (12) ◽  
pp. 2817-2824 ◽  
Author(s):  
A. Haghighatzadeh ◽  
H. Golnabi

2020 ◽  
Author(s):  
Mohit Tyagi ◽  
P. S. Sarkar ◽  
R. S. Sengar ◽  
Ashwani Kumar ◽  
Jagannath ◽  
...  

Author(s):  
Yosuke Yuri ◽  
Nobumasa Miyawaki ◽  
Tomihiro Kamiya ◽  
Watalu Yokota ◽  
Kazuo Arakawa ◽  
...  

Sensors ◽  
2020 ◽  
Vol 20 (9) ◽  
pp. 2503
Author(s):  
Kostas Amoiropoulos ◽  
Georgia Kioselaki ◽  
Nikolaos Kourkoumelis ◽  
Aris Ikiades

Using either bulk or fiber optics the profile of laser beams can be altered from Gaussian to top-hat or hollow beams allowing enhanced performance in applications like laser cooling, optical trapping, and fiber sensing. Here, we report a method based on multimode Plastic Optical Fibers (POF) long-tapers, to tweak the beam profile from near Gaussian to a hollow beam, by generating surface irregularities on the conical sections of the taper with a heat-and-pull technique. Furthermore, a cutback technique applied on long tapers expanded the output beam profile by more than twice the numerical aperture (NA) of the fiber. The enhanced sensitivity and detection efficiency of the extended profile was tested on a fiber optical ice sensor related to aviation safety.


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