Flat-top beam profile generated using a fiber-bundle prism-coupled beam shaper

2011 ◽  
Vol 284 (12) ◽  
pp. 2817-2824 ◽  
Author(s):  
A. Haghighatzadeh ◽  
H. Golnabi
1997 ◽  
Vol 29 (2) ◽  
pp. 57-61 ◽  
Author(s):  
W.C. Yen ◽  
C.T. Huang ◽  
H.P. Liu ◽  
L.P. Lee
Keyword(s):  

2019 ◽  
Vol 44 (17) ◽  
pp. 4428
Author(s):  
A. López-Vázquez ◽  
Y. M. Torres ◽  
M. S. Billión ◽  
W. M. Pimenta ◽  
J. A. Franco-Villafañe ◽  
...  

2021 ◽  
Vol 22 (15) ◽  
pp. 7788
Author(s):  
Andrea Amaroli ◽  
Praveen Arany ◽  
Claudio Pasquale ◽  
Stefano Benedicenti ◽  
Alessandro Bosco ◽  
...  

The tremendous therapeutic potential of photobiomodulation therapy in different branches of medicine has been described in the literature. One of the molecular mechanisms for this treatment implicates the mitochondrial enzyme, cytochrome C oxidase. However, the efficacy and consistency of clinical outcomes with photobiomodulation treatments has been fiercely debated. This work was motivated by this need to improve photobiomodulation devices and delivery approaches. We designed a novel hand-piece with a flat-top beam profile of irradiation. We compared the beam profile versus a standard hand-piece and a fibre probe. We utilized isolated mitochondria and performed treatments at various spots within the beam, namely, the centre, left and right edge. We examined mitochondrial activity by assessing ATP synthesis with the luciferin/luciferase chemiluminescent method as a primary endpoint, while mitochondrial damage was assessed as the secondary endpoint. We observed a uniform distribution of the power density with the flat-top prototype compared to a wide Gaussian beam profile with the standard fibre and standard hand-piece. We noted increased production of ATP in the centre of all three beams with respect to the non-treated controls (p < 0.05). Both the fibre and standard hand-piece demonstrated less increase in ATP synthesis at the edges than the centre (p < 0.05). In contrast, ATP synthesis was increased homogenously in the flat-top handpiece, both in the centre and the edges of the beam. Fibre, standard hand-piece and the flat-top hand-piece prototype have discrete beam distribution characteristics. This significantly affected the mitochondrial activity with respect to their position within the treated areas. Flat-top hand-piece enhances the uniformity of photobiomodulation treatments and can improve the rigour and reproducibility of PBM clinical outcomes.


2005 ◽  
Author(s):  
J. Agresti ◽  
E. D'Ambrosio ◽  
R. DeSalvo ◽  
J. Mackowski ◽  
A. Remillieux ◽  
...  
Keyword(s):  

2006 ◽  
Vol 55 (2) ◽  
pp. 224-229 ◽  
Author(s):  
Takao OTA ◽  
Hikaru YOSHIZUMI ◽  
Hirokazu TSUCHIHASHI ◽  
Takashi MATSUOKA ◽  
Kazuhiko SAKAGUCHI

2011 ◽  
Vol 26 (12) ◽  
pp. 1309-1313 ◽  
Author(s):  
Jie-Hui JING ◽  
Yu-Dong HUANG ◽  
Li LIU ◽  
Zai-Xing JIANG ◽  
Bo JIANG

2020 ◽  
Vol 961 (7) ◽  
pp. 27-36
Author(s):  
A.K. Cherkashin

The purpose of the study is to show how the features of geocartographic way of thinking are manifested in the meta-theory of knowledge based on mathematical formalisms. General cartographic concepts and regularities are considered in the view of metatheoretic analysis using cognitive procedures of fiber bundle from differential geometry. On levels of metainformation generalization, the geocartographic metatheoretic approach to the study of reality is higher than the system-theoretical one. It regulates the type of equations, models, and methods of each intertheory expressed in its own system terms. There is a balance between the state of any system and its geographical environment; therefore the observed phenomena are only explained theoretically in a metatheoretic projection on the corresponding system-thematic layer of the knowledge map. Metatheoretic research enables passing from the systematization of already known patterns to the formation of new knowledge through the scientific stratification of reality. General methods of metatheoretic analysis are mathematically distinguished


1984 ◽  
Vol 23 (17) ◽  
pp. 2859 ◽  
Author(s):  
Shojiro Nemoto
Keyword(s):  

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