Significantly extended life of image intensifiers using Litton's high-performance microchannel plates

1992 ◽  
Author(s):  
Mark E. Gilpin
1993 ◽  
Author(s):  
ASOK RAY ◽  
MIN-KUANG WU ◽  
XIAOWEN DAI ◽  
MARC CARPINO ◽  
CARL LORENZO

2001 ◽  
Vol 47 (9) ◽  
pp. 1614-1621 ◽  
Author(s):  
Igor L Medintz ◽  
Lorenzo Berti ◽  
Charles A Emrich ◽  
Jennifer Tom ◽  
James R Scherer ◽  
...  

Abstract Background: Genetic analysis of microsatellite DNA is a powerful tool used in linkage analysis, gene mapping, and clinical diagnosis. To address the expanding needs of studies of short tandem repeats (STRs), we demonstrated high-performance STR analysis on a high-throughput microchannel plate-based platform. Methods: Energy-transfer-cassette-labeled STR amplicons were separated and typed on a microfabricated 96-channel radial capillary array electrophoresis (CAE) microchannel plate system. Four-color detection was accomplished with a laser-excited confocal fluorescence rotary scanner. Results: Multiplex STR analysis with single base-pair resolution was demonstrated on denaturing polyacrylamide gel media. The high-throughput multiplex capabilities of this genetic analysis platform were demonstrated by the simultaneous separation of STR amplicons representing 122 samples in ninety-six 5.5-cm-long channels in <8 min. Sizing values obtained for these amplicons on the CAE microchannel plate were comparable to those measured on a conventional commercial CAE instrument and exhibit <1% sizing variance. Conclusions: Energy-transfer-cassette labeling and microfabricated CAE microchannel plates allow high-performance multiplex STR analyses.


1972 ◽  
Author(s):  
C. D. Robbins ◽  
R. S. Enck, Jr. ◽  
J. P. Sackinger

Author(s):  
Oswald H. W. Siegmund ◽  
John V. Vallerga ◽  
Nathan T. Darling ◽  
Travis L. Curtis ◽  
Jason B. McPhate ◽  
...  

1993 ◽  
Author(s):  
Yves R. Beauvais ◽  
Paul M. de Groot ◽  
Jean-Charles Chen

Author(s):  
Asok Ray ◽  
Min-Kuang Wu ◽  
Marc Carpino ◽  
Carl F. Lorenzo ◽  
Walter C. Merrill

Author(s):  
A. V. Crewe ◽  
M. Isaacson ◽  
D. Johnson

A double focusing magnetic spectrometer has been constructed for use with a field emission electron gun scanning microscope in order to study the electron energy loss mechanism in thin specimens. It is of the uniform field sector type with curved pole pieces. The shape of the pole pieces is determined by requiring that all particles be focused to a point at the image slit (point 1). The resultant shape gives perfect focusing in the median plane (Fig. 1) and first order focusing in the vertical plane (Fig. 2).


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