Evaluation of the performance of crystalline lens refilled with polymer gel with an improved ex vivo accommodation simulator

Author(s):  
Klaus Ehrmann ◽  
Arthur Ho
Keyword(s):  
Ex Vivo ◽  
Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3552
Author(s):  
Huidong Wei ◽  
James S. Wolffsohn ◽  
Otavio Gomes de Oliveira ◽  
Leon N. Davies

Presbyopia is a common eye disorder among aged people which is attributed to the loss of accommodation of the crystalline lens due to the increasing stiffness. One of the potential techniques to correct presbyopia involves removing the lens substance inside the capsule and replacing it with an artificial lens. The development of such devices, e.g., accommodating intraocular lenses (AIOLs), relies on the understanding of the biomechanical behaviour of the lens capsule and the essential design verification ex vivo. To mimic the eye’s dynamic focusing ability (accommodation), an artificial lens capsule (ALC), from silicone rubber accompanied by a lens radial stretching system (LRSS) was developed. The ALC was manufactured to offer a dimension and deforming behaviour replicating the human lens capsule. The LRSS was calibrated to provide a radial stretch simulating the change of diameter of capsules during accommodating process. The biomechanical function of the ALC was addressed by studying its evolution behaviour and reaction force under multiaxial stretch from the LRSS. The study highlighted the convenience of this application by performing preliminary tests on prototypes of ophthalmic devices (e.g., AIOLs) to restore accommodation.


2009 ◽  
Vol 49 (1) ◽  
pp. 74-83 ◽  
Author(s):  
Raksha Urs ◽  
Fabrice Manns ◽  
Arthur Ho ◽  
David Borja ◽  
Adriana Amelinckx ◽  
...  
Keyword(s):  
Ex Vivo ◽  

2010 ◽  
Vol 50 (11) ◽  
pp. 1041-1047 ◽  
Author(s):  
Raksha Urs ◽  
Arthur Ho ◽  
Fabrice Manns ◽  
Jean-Marie Parel

Photonics ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 207
Author(s):  
Hongqiu Zhang ◽  
Manmohan Singh ◽  
Achuth Nair ◽  
Kirill V. Larin ◽  
Salavat R. Aglyamov

Age-related cataracts are one of the most prevalent causes of visual impairment around the world. Understanding the mechanisms of cataract development and progression is essential to enable early clinical diagnosis and treatment to preserve visual acuity. Reductive chemicals are potential medicines effective on cataract treatment. In this work, we investigated the cataract-induced oxidative damage in the crystalline lens and a kind of reductant, α-lipoic acid (ALA), ability to reduce the damage. We created oxidative environment to investigate the relationship between the progression of oxidative cataract and lenticular biomechanical properties measured by dynamic optical coherence elastography in porcine crystalline lenses ex vivo. The efficacy of ALA to minimize the stiffening of the lens was also quantified. The results showed a significant increase in Young’s modulus of the lens due to the formation of the oxidative cataract. We found a statistically significant difference between Young’s modulus of the lenses stored in phosphate-buffered saline and ALA solution after incubation in H2O2 solution for 3 h (43.0 ± 9.0 kPa versus 20.7 ± 3.5 kPa, respectively). These results show that the lens stiffness increases during oxidative cataract formation, and ALA has the potential to reverse stiffening of the lens caused by oxidative damage.


2015 ◽  
Vol 70 ◽  
pp. 1250-1254
Author(s):  
Tony Matéo ◽  
Yassine Mofid ◽  
Jean-Marc Grégoire ◽  
Frédéric Ossant

2000 ◽  
Author(s):  
Marie Hamaoui ◽  
Jean-Marie A. Parel ◽  
Fabrice Manns ◽  
Hassan Tahi ◽  
Arthur Ho ◽  
...  

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