The clinical availability of oleic acid as an enhancer in optical clearing of skin tissue in vitro

2005 ◽  
Author(s):  
Jingying Jiang ◽  
Ruikang K. Wang
Keyword(s):  
Oleic Acid ◽  
Skin Tissue ◽  
Optical Clearing

Optical clearing of porcine skin tissue in vitro studied by Raman microspectroscopy

2012 ◽  
Vol 17 (1) ◽  
pp. 015004 ◽  
Author(s):  
Deqiu Huang ◽  
Wen Zhang ◽  
Huiqing Zhong ◽  
Honglian Xiong ◽  
Xi Guo ◽  
...  
Keyword(s):  
Raman Microspectroscopy ◽  
Skin Tissue ◽  
Porcine Skin ◽  
Optical Clearing

Availability of thiazone as an enhancer for optical clearing of skin tissue in vitro

2008 ◽  
Author(s):  
Jingying Jiang ◽  
Wei Chen ◽  
Ruikang K. Wang ◽  
Kexin Xu
Keyword(s):  
Skin Tissue ◽  
Optical Clearing

Needleless electrospinning of PVP/PGS fibrous scaffolds for skin tissue engineering applications

2018 ◽  
Author(s):  
Antonios Keirouz ◽  
Giuseppino Fortunato ◽  
Anthony Callanan ◽  
Norbert Radacsi
Keyword(s):  
Tissue Engineering ◽  
Tensile Modulus ◽  
Dermal Fibroblasts ◽  
Skin Tissue ◽  
Skin Substitute ◽  
Electrospinning Technique ◽  
Skin Tissue Engineering ◽  
Needleless Electrospinning ◽  
High Concentrations

Scaffolds and implants used for tissue engineering need to be adapted for their mechanical properties with respect to their environment within the human body. Therefore, a novel composite for skin tissue engineering is presented by use of blends of Poly(vinylpyrrolidone) (PVP) and Poly(glycerol sebacate) (PGS) were fabricated via the needleless electrospinning technique. The formed PGS/PVP blends were morphologically, thermochemically and mechanically characterized. The morphology of the developed fibers related to the concentration of PGS, with high concentrations of PGS merging the fibers together plasticizing the scaffold. The tensile modulus appeared to be affected by the concentration of PGS within the blends, with an apparent decrease in the elastic modulus of the electrospun mats and an exponential increase of the elongation at break. Ultraviolet (UV) crosslinking of PGS/PVP significantly decreased and stabilized the wettability of the formed fiber mats, as indicated by contact angle measurements. In vitro examination showed good viability and proliferation of human dermal fibroblasts over the period of a week. The present findings provide important insights for tuning the elastic properties of electrospun material by incorporating this unique elastomer, as a promising future candidate for skin substitute constructs.

Atorvastatin-Loaded Oleic Acid Nanoglobules for Oral Administration: In Vitro Characterization and Biopharmaceutical Evaluation

2013 ◽  
Vol 9 (2) ◽  
pp. 202-210
Author(s):  
Pradum Pundlikrao Ige ◽  
Nilesh Ashok Bachhav ◽  
Hitendra Shaligram Mahajan ◽  
Pankaj Padmakar Nerkar ◽  
Surendra Ganeshlal Gattani
Keyword(s):  
Oleic Acid ◽  
Oral Administration ◽  
In Vitro Characterization

scholarly journals Interaction of Lactoferrin with Unsaturated Fatty Acids: In Vitro and In Vivo Study of Human Lactoferrin/Oleic Acid Complex Cytotoxicity

Materials ◽  
2021 ◽  
Vol 14 (7) ◽  
pp. 1602
Author(s):  
Anna Elizarova ◽  
Alexey Sokolov ◽  
Valeria Kostevich ◽  
Ekaterina Kisseleva ◽  
Evgeny Zelenskiy ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Structural Changes ◽  
Unsaturated Fatty Acids ◽  
Structural Features ◽  
Control Group ◽  
Acid Complex ◽  
Hepatoma 22A ◽  
Constitutive Parameters

As shown recently, oleic acid (OA) in complex with lactoferrin (LF) causes the death of cancer cells, but no mechanism(s) of that toxicity have been disclosed. In this study, constitutive parameters of the antitumor effect of LF/OA complex were explored. Complex LF/OA was prepared by titrating recombinant human LF with OA. Spectral analysis was used to assess possible structural changes of LF within its complex with OA. Structural features of apo-LF did not change within the complex LF:OA = 1:8, which was toxic for hepatoma 22a cells. Cytotoxicity of the complex LF:OA = 1:8 was tested in cultured hepatoma 22a cells and in fresh erythrocytes. Its anticancer activity was tested in mice carrying hepatoma 22a. In mice injected daily with LF-8OA, the same tumor grew significantly slower. In 20% of animals, the tumors completely resolved. LF alone was less efficient, i.e., the tumor growth index was 0.14 for LF-8OA and 0.63 for LF as compared with 1.0 in the control animals. The results of testing from 48 days after the tumor inoculation showed that the survival rate among LF-8OA-treated animals was 70%, contrary to 0% rate in the control group and among the LF-treated mice. Our data allow us to regard the complex of LF and OA as a promising tool for cancer treatment.

scholarly journals 075 Generation and quantification of oxidized squalene to develop an acne testing model in vitro based on skin tissue engineering

2016 ◽  
Vol 136 (9) ◽  
pp. S173 ◽  
Author(s):  
N. Esselin ◽  
C. Capallere ◽  
C. Meyrignac ◽  
C. Plaza ◽  
C. Coquet ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Skin Tissue ◽  
Testing Model ◽  
Skin Tissue Engineering

scholarly journals Microbial biohydrogenation of oleic acid to trans isomers in vitro

2002 ◽  
Vol 43 (2) ◽  
pp. 290-296 ◽  
Author(s):  
Erin E. Mosley ◽  
Gary L. Powell ◽  
Melissa B. Riley ◽  
Thomas C. Jenkins
Keyword(s):  
Oleic Acid ◽  
Trans Isomers
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