Integrated amplifier with complementary organic electrochemical transistors for high-sensitivity ion detection and real-time monitoring

2021 ◽  
Author(s):  
Fabrizio Torricelli ◽  
Paolo Romele ◽  
Paschalis Gkoupidenis ◽  
Dimitrios A. Koutsouras ◽  
Katharina Lieberth ◽  
...  
Keyword(s):  
Real Time ◽  
High Sensitivity ◽  
Real Time Monitoring ◽  
Ion Detection ◽  
Organic Electrochemical Transistors

scholarly journals Multiscale real time and high sensitivity ion detection with complementary organic electrochemical transistors amplifier

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Paolo Romele ◽  
Paschalis Gkoupidenis ◽  
Dimitrios A. Koutsouras ◽  
Katharina Lieberth ◽  
Zsolt M. Kovács-Vajna ◽  
...  
Keyword(s):  
Real Time ◽  
High Sensitivity ◽  
Ion Detection ◽  
Organic Electrochemical Transistors

scholarly journals Metal Oxide Nanorods-Based Sensor Array for Selective Detection of Biomarker Gases

Sensors ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 1922
Author(s):  
Gwang Su Kim ◽  
Yumin Park ◽  
Joonchul Shin ◽  
Young Geun Song ◽  
Chong-Yun Kang
Keyword(s):  
Real Time ◽  
Sensor Array ◽  
High Sensitivity ◽  
Gas Analysis ◽  
Diagnostic Methods ◽  
Real Time Monitoring ◽  
Non Invasive ◽  
Sensitivity And Selectivity ◽  
Breath Gas Analysis ◽  
Angle Method

The breath gas analysis through gas phase chemical analysis draws attention in terms of non-invasive and real time monitoring. The array-type sensors are one of the diagnostic methods with high sensitivity and selectivity towards the target gases. Herein, we presented a 2 × 4 sensor array with a micro-heater and ceramic chip. The device is designed in a small size for portability, including the internal eight-channel sensor array. In2O3 NRs and WO3 NRs manufactured through the E-beam evaporator’s glancing angle method were used as sensing materials. Pt, Pd, and Au metal catalysts were decorated for each channel to enhance functionality. The sensor array was measured for the exhaled gas biomarkers CH3COCH3, NO2, and H2S to confirm the respiratory diagnostic performance. Through this operation, the theoretical detection limit was calculated as 1.48 ppb for CH3COCH3, 1.9 ppt for NO2, and 2.47 ppb for H2S. This excellent detection performance indicates that our sensor array detected the CH3COCH3, NO2, and H2S as biomarkers, applying to the breath gas analysis. Our results showed the high potential of the gas sensor array as a non-invasive diagnostic tool that enables real-time monitoring.

Organic Electrochemical Transistors for Real‐Time Monitoring of In Vitro Silver Nanoparticle Toxicity

2019 ◽  
Vol 4 (1) ◽  
pp. 1900204 ◽  
Author(s):  
Francesco Decataldo ◽  
Marianna Barbalinardo ◽  
Denis Gentili ◽  
Marta Tessarolo ◽  
Maria Calienni ◽  
...  
Keyword(s):  
Real Time ◽  
Silver Nanoparticle ◽  
Real Time Monitoring ◽  
Nanoparticle Toxicity ◽  
Organic Electrochemical Transistors

Organic Electrochemical Transistors: Smart Devices for Real‐Time Monitoring of Cellular Vitality

2019 ◽  
Vol 4 (9) ◽  
pp. 1900207 ◽  
Author(s):  
Francesco Decataldo ◽  
Marianna Barbalinardo ◽  
Marta Tessarolo ◽  
Vito Vurro ◽  
Maria Calienni ◽  
...  
Keyword(s):  
Real Time ◽  
Smart Devices ◽  
Real Time Monitoring ◽  
Cellular Vitality ◽  
Organic Electrochemical Transistors

Real-time monitoring AP site incision caused by APE1 using a modified hybridization probe

2016 ◽  
Vol 8 (4) ◽  
pp. 862-868 ◽  
Author(s):  
Bin Liu ◽  
Lan Peng
Keyword(s):  
Real Time ◽  
Sensitivity And Specificity ◽  
High Sensitivity ◽  
Fluorescence Method ◽  
Real Time Monitoring ◽  
Hybridization Probe ◽  
Linear Probe ◽  
Ap Site

A real time fluorescence method with wide promising applications was developed for APE1 assay with high sensitivity and specificity by using a double-stranded linear probe as a substrate and reporter molecule.

scholarly journals Regenerable Bead-Based Microfluidic Device with integrated THIN-Film Photodiodes for Real Time Monitoring of DNA Detection

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 953
Author(s):  
Catarina R. F. Caneira ◽  
Denis R. Santos ◽  
Virginia Chu ◽  
João P. Conde
Keyword(s):  
Thin Film ◽  
Real Time ◽  
Microfluidic Device ◽  
Low Cost ◽  
High Sensitivity ◽  
Significant Loss ◽  
Real Time Monitoring ◽  
Target Dna ◽  
On Chip ◽  
Biosensing System

Nanoporous microbead-based microfluidic systems for biosensing applications allow enhanced sensitivities, while being low cost and amenable for miniaturization. The regeneration of the microfluidic biosensing system results in a further decrease in costs while the integration of on-chip signal transduction enhances portability. Here, we present a regenerable bead-based microfluidic device, with integrated thin-film photodiodes, for real-time monitoring of molecular recognition between a target DNA and complementary DNA (cDNA). High-sensitivity assay cycles could be performed without significant loss of probe DNA density and activity, demonstrating the potential for reusability, portability and reproducibility of the system.

scholarly journals High-sensitivity ion detection at low voltages with current-driven organic electrochemical transistors

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Matteo Ghittorelli ◽  
Leona Lingstedt ◽  
Paolo Romele ◽  
N. Irina Crăciun ◽  
Zsolt Miklós Kovács-Vajna ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Ion Detection ◽  
Organic Electrochemical Transistors

A fluorescent probe with an aggregation-enhanced emission feature for real-time monitoring of low carbon dioxide levels

2015 ◽  
Vol 3 (29) ◽  
pp. 7621-7626 ◽  
Author(s):  
Huan Wang ◽  
Didi Chen ◽  
Yahui Zhang ◽  
Pai Liu ◽  
Jianbing Shi ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Real Time ◽  
Fluorescent Probe ◽  
High Sensitivity ◽  
Emission Feature ◽  
Low Carbon ◽  
Real Time Monitoring ◽  
Low Levels ◽  
Carbon Dioxide Levels

The presented method provides a facile and rapid approach to detect low levels of CO2 with high sensitivity, selectivity and reversibility.

scholarly journals Real-Time Monitoring of a Botulinum Neurotoxin Using All-Carbon Nanotube-Based Field-Effect Transistor Devices

Sensors ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 4235 ◽  
Author(s):  
Nam Lee ◽  
Seung-Hoon Nahm ◽  
Insung Choi
Keyword(s):  
Carbon Nanotube ◽  
Real Time ◽  
Field Effect ◽  
Botulinum Neurotoxin ◽  
Field Effect Transistor ◽  
Detection System ◽  
High Sensitivity ◽  
Real Time Monitoring ◽  
Unique Peptide ◽  
Effect Transistor

The possibility of exposure to botulinum neurotoxin (BoNT), a powerful and potential bioterrorism agent, is considered to be ever increasing. The current gold-standard assay, live-mouse lethality, exhibits high sensitivity but has limitations including long assay times, whereas other assays evince rapidity but lack factors such as real-time monitoring or portability. In this study, we aimed to devise a novel detection system that could detect BoNT at below-nanomolar concentrations in the form of a stretchable biosensor. We used a field-effect transistor with a p-type channel and electrodes, along with a channel comprising aligned carbon nanotube layers to detect the type E light chain of BoNT (BoNT/E-Lc). The detection of BoNT/E-Lc entailed observing the cleavage of a unique peptide and the specific bonding between BoNT/E-Lc and antibody BoNT/E-Lc (Anti-BoNT/E-Lc). The unique peptide was cleaved by 60 pM BoNT/E-Lc; notably, 52 fM BoNT/E-Lc was detected within 1 min in the device with the antibody in the bent state. These results demonstrated that an all-carbon nanotube-based device (all-CNT-based device) could be produced without a complicated fabrication process and could be used as a biosensor with high sensitivity, suggesting its potential development as a wearable BoNT biosensor.

Real-time monitoring of skin ethanol gas by a high-sensitivity gas phase biosensor (bio-sniffer) for the non-invasive evaluation of volatile blood compounds

2019 ◽  
Vol 129 ◽  
pp. 245-253 ◽  
Author(s):  
Takahiro Arakawa ◽  
Takuma Suzuki ◽  
Masato Tsujii ◽  
Kenta Iitani ◽  
Po-Jen Chien ◽  
...  
Keyword(s):  
Real Time ◽  
Gas Phase ◽  
High Sensitivity ◽  
Real Time Monitoring ◽  
Non Invasive ◽  
Invasive Evaluation
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