Accuracy of catheter-based near-infrared auto-fluorescence detection in human coronary plaques

2021 ◽  
Author(s):  
Mie Kunio ◽  
Joseph A. Gardecki ◽  
Kohei Watanabe ◽  
Kensuke Nishimiya ◽  
Daisuke Yamada ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Near Infrared ◽  
Auto Fluorescence

Bioapplications and biotechnologies of upconversion nanoparticle-based nanosensors

The Analyst ◽  
2016 ◽  
Vol 141 (12) ◽  
pp. 3601-3620 ◽  
Author(s):  
Chengli Wang ◽  
Xiaomin Li ◽  
Fan Zhang
Keyword(s):  
Optical Properties ◽  
High Resistance ◽  
Near Infrared ◽  
Signal To Noise Ratio ◽  
Upconversion Nanoparticles ◽  
Signal To Noise ◽  
Noise Ratio ◽  
Auto Fluorescence ◽  
New Generation ◽  
Narrow Emission

Upconversion nanoparticles (UCNPs), which can emit ultraviolet/visible (UV/Vis) light under near-infrared (NIR) excitation, are regarded as a new generation of nanoprobes because of their unique optical properties, including a virtually zero auto-fluorescence background for the improved signal-to-noise ratio, narrow emission bandwidths and high resistance to photo-bleaching.

Augmented microscopy with near-infrared fluorescence detection

2015 ◽  
Author(s):  
Jeffrey R. Watson ◽  
Nikolay Martirosyan ◽  
Jesse Skoch ◽  
G. Michael Lemole ◽  
Rein Anton ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Near Infrared ◽  
Near Infrared Fluorescence

scholarly journals Protein enhanced NIR-IIb emission of indocyanine green for functional bioimaging

2020 ◽  
Author(s):  
Mubin He ◽  
Di Wu ◽  
Yuhuang Zhang ◽  
Xiaoxiao Fan ◽  
Hui Lin ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Clinical Application ◽  
Spatial Resolution ◽  
Near Infrared ◽  
Protein Solutions ◽  
Lymph System ◽  
Fetal Bovine ◽  
Auto Fluorescence

AbstractFluorescence imaging performed in the 1500-1700 nm spectral range (labeled as near-infrared IIb, NIR-IIb) promises high imaging contrast and spatial resolution for its little photon scattering effect and minimum auto-fluorescence. Though inorganic and organic probes have been developed for NIR-IIb bioimaging, most are in preclinical stage, hampering further clinical application. Herein, we showed that indocyanine green (ICG), an US Food and Drug Administration (FDA)-approved agent, exhibited remarkable amount of NIR-IIb emission when dissolved into different protein solutions, including human serum albumin, rat bile, and fetal bovine serum. We performed fluorescence imaging in NIR-IIb window to visualize structures of lymph system, extrahepatic biliary tract and cerebrovascular. Results demonstrated that proteins promoted NIR-IIb emission of ICG in vivo and that NIR-IIb imaging with ICG preserved higher signal-to-background ratio (SBR) and spatial resolution compared with the conventional near-infrared II (NIR-II) fluorescence imaging. Our findings confirm that NIR-IIb fluorescence imaging can be successfully performed using the clinically approved agent ICG. Further clinical application in NIR-IIb region would hopefully be carried out with appropriate ICG-protein solutions.

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