Assessing fluorescence detection and effective photothermal therapy of near-infrared polymer nanoparticles using alginate tissue phantoms

2018 ◽  
Vol 50 (10) ◽  
pp. 1040-1049 ◽  
Author(s):  
Eleanor E. McCabe-Lankford ◽  
Theodore L. Brown ◽  
Nicole H. Levi-Polyachenko
Keyword(s):  
Fluorescence Detection ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Tissue Phantoms

REVIEW OF METAL, CARBON AND POLYMER NANOPARTICLES FOR INFRARED PHOTOTHERMAL THERAPY

Nano LIFE ◽  
2013 ◽  
Vol 03 (03) ◽  
pp. 1330002 ◽  
Author(s):  
ELIZABETH G. GRAHAM ◽  
CHRISTOPHER M. MACNEILL ◽  
NICOLE H. LEVI-POLYACHENKO
Keyword(s):  
Drug Delivery ◽  
Thermal Ablation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Conductive Polymer ◽  
Polymer Nanoparticles ◽  
Electrically Conductive ◽  
Nir Light ◽  
Reduced Graphene ◽  
Main Emphasis

The aim of this review is to provide an up-to-date overview of nanoparticles developed for use as photothermal therapy agents (PTT) over the past five years. The main emphasis is on nanoparticles that absorb near infrared (NIR) light for PTT of cancer. Mild hyperthermia, including drug delivery, versus thermal ablation is also discussed. Recent advances in the synthesis of highly anisotropic novel metal nanoparticles for PTT are described. New metals and metal oxide complexes, as well as the use of quantum dots for PTT and as imaging agents are newer areas of development that are explained. This review also highlights current progress in the development of carbon nanoparticles, including reduced graphene oxide for both thermal ablation as well as drug delivery. The review culminates in the recent use electrically conductive polymer nanoparticles for hyperthermia. The advantages and unique features of these contemporary nanoparticles being used for PTT are highlighted. The goal of the present work is to describe the recent evolution of nanoparticles for NIR stimulated PTT, and highlight the innovations and future directions.

Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

2017 ◽  
Vol 5 (2) ◽  
pp. 382-387 ◽  
Author(s):  
Yuping Yan ◽  
Qi Yang ◽  
Jie Wang ◽  
Hongyu Jin ◽  
Jing Wang ◽  
...  
Keyword(s):  
Light Absorption ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Step Process ◽  
Theranostic Agent ◽  
Nir Light ◽  
Doped Polymer

We report a two-step process to construct heteropoly blue (HPB) doped polymer nanoparticles with efficient near-infrared (NIR) light absorption and photothermal conversion efficiency of ∼23%.

Second Near-Infrared Photoactivatable Biocompatible Polymer Nanoparticles for Effective in Vitro and in Vivo Cancer Theranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Fei Wang ◽  
Xiaoju Men ◽  
Haobin Chen ◽  
Feixue Mi ◽  
Mengze Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Tissue Penetration ◽  
Biocompatible Polymer ◽  
Cancer Theranostics ◽  
Maximum Permissible Exposure

Photoacoustic imaging (PAI)-guided photothermal therapy (PTT) has drawn considerable attention due to the deeper tissue penetration and higher maximum permissible exposure. However, current phototheranostic agents are greatly restricted to the...

scholarly journals NEAR INFRARED LIGHT HEATING OF SOFT TISSUE PHANTOMS CONTAINING NANOPARTICLES

2014 ◽  
Vol 13 (1) ◽  
pp. 13
Author(s):  
S. Eibner ◽  
R. A. O. Jaime ◽  
B. Lamien ◽  
R. L. Q. Basto ◽  
H. R. B. Orlande ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Soft Tissue ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Titanium Dioxide Nanoparticles ◽  
Local Heating ◽  
Infrared Camera ◽  
Infrared Light ◽  
Thermal Paste ◽  
Tissue Phantoms

The objective of this paper is to investigate the effect of the addition of nanoparticles to soft tissue phantoms, aiming at the enhancement of photothermal therapy for cancer. The phantoms were made of Polyvinyl chloride-plastisol (PVC-P), with two different nanoparticles, namely, titanium dioxide nanoparticles (TiO2) and silica nanoparticles (SiO2). A phantom without nanoparticles and a phantom containing a thermal paste were also manufactured for comparison purposes. The PVC-P phantom is transparent to the near infrared laser light, whereas the addition of titanium dioxide nanoparticles modified the optical properties enhancing the local heating, as demonstrated through experiments with a laser-diode and an infrared camera.

scholarly journals RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Dongye Zheng ◽  
Peiwen Yu ◽  
Zuwu Wei ◽  
Cheng Zhong ◽  
Ming Wu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Reticuloendothelial System ◽  
The Body ◽  
Polymer Nanoparticles ◽  
Infrared Light ◽  
Great Promise ◽  
Therapeutic Effects ◽  
Immune Recognition

Abstract Semiconducting conjugated polymer nanoparticles (SPNs) represent an emerging class of phototheranostic materials with great promise for cancer treatment. In this report, low-bandgap electron donor–acceptor (D–A)-conjugated SPNs with surface cloaked by red blood cell membrane (RBCM) are developed for highly effective photoacoustic imaging and photothermal therapy. The resulting RBCM-coated SPN (SPN@RBCM) displays remarkable near-infrared light absorption and good photostability, as well as high photothermal conversion efficiency for photoacoustic imaging and photothermal therapy. Particularly, due to the small size (< 5 nm), SPN@RBCM has the advantages of deep tumor penetration and rapid clearance from the body with no appreciable toxicity. The RBCM endows the SPNs with prolonged systematic circulation time, less reticuloendothelial system uptake and reduced immune-recognition, hence improving tumor accumulation after intravenous injection, which provides strong photoacoustic signals and exerts excellent photothermal therapeutic effects. Thus, this work provides a valuable paradigm for safe and highly efficient tumor photoacoustic imaging and photothermal therapy for further clinical translation.

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