Development of fast photoacoustic microscopy system for small animal brain imaging

2021 ◽  
Author(s):  
Mohsin Zafar ◽  
James I. Matchynski ◽  
Rayyan Manwar ◽  
Seyed M. Ranjbaran ◽  
Alana C. Conti ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Small Animal ◽  
Photoacoustic Microscopy ◽  
Animal Brain

scholarly journals An Optimized Registration Workflow and Standard Geometric Space for Small Animal Brain Imaging

NeuroImage ◽  
2021 ◽  
pp. 118386
Author(s):  
Horea-Ioan Ioanas ◽  
Markus Marks ◽  
Valerio Zerbi ◽  
Mehmet Fatih Yanik ◽  
Markus Rudin
Keyword(s):  
Brain Imaging ◽  
Small Animal ◽  
Animal Brain ◽  
Geometric Space

Quantitative analysis of L-SPECT system for small animal brain imaging

2016 ◽  
Author(s):  
Tasneem Rahman ◽  
Murat Tahtali ◽  
Mark R. Pickering
Keyword(s):  
Quantitative Analysis ◽  
Brain Imaging ◽  
Small Animal ◽  
Animal Brain ◽  
Spect System

scholarly journals GATE simulation of a new design of pinhole SPECT system for small animal brain imaging

2017 ◽  
Vol 12 (01) ◽  
pp. C01085-C01085 ◽  
Author(s):  
D. Uzun Ozsahin ◽  
L. Bläckberg ◽  
G. El Fakhri ◽  
H. Sabet
Keyword(s):  
Brain Imaging ◽  
Small Animal ◽  
Pinhole Spect ◽  
Animal Brain ◽  
Spect System

scholarly journals High-speed widefield photoacoustic microscopy of small-animal hemodynamics

2018 ◽  
Vol 9 (10) ◽  
pp. 4689 ◽  
Author(s):  
Bangxin Lan ◽  
Wei Liu ◽  
Ya-chao Wang ◽  
Junhui Shi ◽  
Yang Li ◽  
...  
Keyword(s):  
High Speed ◽  
Small Animal ◽  
Photoacoustic Microscopy

scholarly journals Cerebrovascular responses of the rat brain to noxious stimuli as examined by functional near-infrared whole brain imaging

2012 ◽  
Vol 107 (10) ◽  
pp. 2853-2865 ◽  
Author(s):  
Ji-Wei He ◽  
Fenghua Tian ◽  
Hanli Liu ◽  
Yuan Bo Peng
Keyword(s):  
Brain Imaging ◽  
Near Infrared ◽  
Small Animal ◽  
Nir Spectroscopy ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Hemodynamic Changes ◽  
Whole Brain ◽  
Brain Hemodynamics

While near-infrared (NIR) spectroscopy has been increasingly used to detect stimulated brain activities with an advantage of dissociating regional oxy- and deoxyhemoglobin concentrations simultaneously, it has not been utilized much in pain research. Here, we investigated and demonstrated the feasibility of using this technique to obtain whole brain hemodynamics in rats and speculated on the functional relevance of the NIR-based hemodynamic signals during pain processing. NIR signals were emitted and collected using a 26-optodes array on rat's dorsal skull surface after the removal of skin. Following the subcutaneous injection of formalin (50 μl, 3%) into a hindpaw, several isolable brain regions showed hemodynamic changes, including the anterior cingulate cortex, primary/secondary somatosensory cortexes, thalamus, and periaqueductal gray ( n = 6). Time courses of hemodynamic changes in respective regions matched with the well-documented biphasic excitatory response. Surprisingly, an atypical pattern (i.e., a decrease in oxyhemoglobin concentration with a concomitant increase in deoxyhemoglobin concentration) was seen in phase II. In a separate group of rats with innocuous brush and noxious pinch of the same area ( n = 11), results confirmed that the atypical pattern occurred more likely in the presence of nociception than nonpainful stimulation, suggesting it as a physiological substrate when the brain processes pain. In conclusion, the NIR whole brain imaging provides a useful alternative to study pain in vivo using small-animal models. Our results support the notion that neurovascular response patterns depend on stimuli, bringing attention to the interpretation of vascular-based neuroimaging data in studies of pain.

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