scholarly journals Exogenous sex hormone effects on brain microstructure in women: a diffusion MRI study in the UK Biobank

2020 ◽  
Author(s):  
Leila Nabulsi ◽  
Katherine E. Lawrence ◽  
Vigneshwaran Santhalingam ◽  
Zvart Abaryan ◽  
Christina P. Boyle ◽  
...  
Keyword(s):  
Diffusion Mri ◽  
Sex Hormone ◽  
Uk Biobank ◽  
Hormone Effects ◽  
Brain Microstructure ◽  
The Uk ◽  
Mri Study

scholarly journals Microstructural differences in white matter tracts across middle to late adulthood: a diffusion MRI study on 7167 UK Biobank participants

2021 ◽  
Vol 98 ◽  
pp. 160-172
Author(s):  
Wen-Yih Isaac Tseng ◽  
Yung-Chin Hsu ◽  
Chang-Le Chen ◽  
Yun-Jing Kang ◽  
Te-Wei Kao ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Mri ◽  
Uk Biobank ◽  
White Matter Tracts ◽  
Late Adulthood ◽  
Mri Study

scholarly journals Exogenous sex hormone effects on brain microstructure in women: a diffusion MRI study in the UK Biobank

2020 ◽  
Author(s):  
Leila Nabulsi ◽  
Katherine E. Lawrence ◽  
Vigneshwaran Santhalingam ◽  
Zvart Abaryan ◽  
Christina P. Boyle ◽  
...  
Keyword(s):  
White Matter ◽  
Volume Fraction ◽  
Brain Aging ◽  
Sex Hormone ◽  
Uk Biobank ◽  
Fractional Polynomial ◽  
Age Related ◽  
Hormone Exposure ◽  
The Uk ◽  
Quadratic Models

ABSTRACTThis study used advanced diffusion-weighted MRI (dMRI) to examine the association between exogenous sex-hormone exposure and the brain’s white matter aging trajectories in a large population-based sample of women. To investigate the effect of pre- and post-menopausal sex hormones on brain aging, cross-sectional brain dMRI data from the UK Biobank was analyzed using 3 diffusion models: conventional diffusion tensor imaging (DTI), the tensor distribution function (TDF), and neurite orientation dispersion and density imaging (NODDI). Mean skeletonized diffusivity measures were extracted and averaged across the whole brain, including fractional anisotropy, isotropic volume fraction, intracellular volume fraction and orientation dispersion index. We used general linear models and fractional polynomial regressions to characterize age-related trajectories in white matter measures following hormone therapy (HT) and oral contraceptive (OC) use in women (HT analysis: N=8,301; OC analysis: N=8,913). Sex hormone treatment (HT and OC) was statistically associated with the aging trends in white matter measures. Estrogen therapy alone appeared to exert a neuroprotective effect on age-related white matter processes, compared to HT containing both estrogen and progestin therapy – which was associated with accelerated aging-related processes in women. These results support the hypothesis that exogenous sex hormone exposure may impact white matter aging; white matter metrics may also be sensitive to sex hormone levels in women. Furthermore, we discuss the necessity to test alternative models for lifespan trajectories beyond popular linear and quadratic models, especially when dealing with large samples. Fractional polynomial models may provide a more adaptive alternative to linear or quadratic models.

scholarly journals Evaluating the genetic effects of sex hormone on the development of mental traits: a polygenic score analysis and genome-wide genetic interaction analysis in the UK Biobank cohort

2020 ◽  
Author(s):  
Xiao Liang ◽  
ShiQiang Cheng ◽  
Jing Ye ◽  
XiaoMeng Chu ◽  
Yan Wen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fluid Intelligence ◽  
Genetic Interaction ◽  
Interaction Analysis ◽  
Genetic Effects ◽  
Sex Hormone ◽  
Uk Biobank ◽  
Genome Wide ◽  
Study Results ◽  
The Uk

Abstract Objective: To evaluate the genetic effects of sex hormone on the development of mental traits.Methods: The SNPs significantly associated with sex hormone traits were driven from a two-stage genome-wide association study (GWAS). Four sex hormone were selected in this study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk scores (PRS) of sex hormone traits were calculated from individual-level genotype data of the UK Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, genome-wide genetic interaction study (GWGIS) was performed to detect novel candidate genes interacting with the sex hormone on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0.Results: We observed positive associations between SHBG and the frequency of alcohol consumption (b=0.01, p=3.84×10–11) in males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b=0.01, p=1,96×10–8), fluid intelligence (b=0.01, p=1.90×10–2) and the frequency of smoking (b=0.01, p=1.77×10–2) in males. Moreover, SHBG was associated with the frequency of alcohol consumption (b=0.01, p=2.60×10–3), fluid intelligence (b=0.01, p=4.25×10–2) and anxiety (b=-0.01, p=3.79×10–2) in females. Finally, GWGIS identified one significant loci, Tenascin R (TNR) (rs34633780, p=3.45×10–8) interacting with total testosterone for fluid intelligence.Conclusion: Our study results support the genetic effects of sex hormone on the development of intelligence and the frequency of alcohol consumption.

Longitudinal changes in serum testosterone and sex hormone‐binding globulin in men aged 40–69 years from the UK Biobank

2021 ◽  
Author(s):  
Ross J. Marriott ◽  
Kevin Murray ◽  
Graeme J. Hankey ◽  
Laurens Manning ◽  
Girish Dwivedi ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Uk Biobank ◽  
Hormone Binding ◽  
Longitudinal Changes ◽  
The Uk

Low birthweight is associated with poorer limb muscle mass and grip strength in middle age: findings from the UK Biobank Imaging Enhancement

2019 ◽  
Author(s):  
Elizabeth Curtis ◽  
Justin Liu ◽  
Kate Ward ◽  
Karen Jameson ◽  
Zahra Raisi-Estabragh ◽  
...  
Keyword(s):  
Grip Strength ◽  
Muscle Mass ◽  
Low Birthweight ◽  
Middle Age ◽  
Limb Muscle ◽  
Uk Biobank ◽  
The Uk

Contrasting Broad- and Clinically- defined Polygenic Indicators of Depression and Depression-related Phenotypes in Adults and Children

2020 ◽  
Author(s):  
John E. McGeary ◽  
Chelsie Benca-Bachman ◽  
Victoria Risner ◽  
Christopher G Beevers ◽  
Brandon Gibb ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Cognitive Reappraisal ◽  
Twin Studies ◽  
European Ancestry ◽  
Summary Statistics ◽  
Depression Severity ◽  
Uk Biobank ◽  
Polygenic Scores ◽  
Adults And Children ◽  
The Uk

Twin studies indicate that 30-40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGSBD) and clinical- (PGSMDD) depression summary statistics from the UK Biobank using independent cohorts of adults (N=210; 100% European Ancestry) and children (N=728; 70% European Ancestry) who have been extensively phenotyped for depression and related neurocognitive phenotypes. PGS associations with depression severity and diagnosis were generally modest, and larger in adults than children. Polygenic prediction of depression-related phenotypes was mixed and varied by PGS. Higher PGSBD, in adults, was associated with a higher likelihood of having suicidal ideation, increased brooding and anhedonia, and lower levels of cognitive reappraisal; PGSMDD was positively associated with brooding and negatively related to cognitive reappraisal. Overall, PGS based on both broad and clinical depression phenotypes have modest utility in adult and child samples of depression.

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