The association of prediagnostic circulating levels of cardiometabolic markers, testosterone and sex hormone‐binding globulin with risk of breast cancer among normal weight postmenopausal women in the UK Biobank

2021 ◽  
Author(s):  
Rhonda S. Arthur ◽  
Andrew J. Dannenberg ◽  
Thomas E. Rohan
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Women ◽  
Normal Weight ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Uk Biobank ◽  
Hormone Binding ◽  
Cardiometabolic Markers ◽  
The Uk ◽  
Circulating Levels

scholarly journals Serum concentrations of estrogens, sex hormone-binding globulin, and androgens and risk of breast cancer in postmenopausal women

2006 ◽  
Vol 119 (10) ◽  
pp. 2402-2407 ◽  
Author(s):  
Laila Adly ◽  
Deirdre Hill ◽  
Mark E. Sherman ◽  
Susan R. Sturgeon ◽  
Thomas Fears ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Serum Concentrations ◽  
Hormone Binding

scholarly journals No association between circulating levels of testosterone and sex hormone-binding globulin and risk of COVID-19 mortality in UK biobank

2020 ◽  
Author(s):  
Xikang Fan ◽  
Jing Yang ◽  
Jiayu Wang ◽  
Cheng Yin ◽  
Meng Zhu ◽  
...  
Keyword(s):  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Uk Biobank ◽  
Hormone Binding ◽  
Disaggregated Data ◽  
Death Cases ◽  
Circulating Levels

Background: Sex-disaggregated data suggest that men with coronavirus disease 2019 (COVID-19) are more likely to die than women. Whether circulating testosterone or sex hormone-binding globulin (SHBG) contributes to such sex differences remains unknown. Objective: To evaluate the associations of circulating total testosterone (TT), free testosterone (FT), and SHBG with COVID-19 mortality. Design: Prospective analysis. Setting: UK Biobank. Participants: We included 1306 COVID-19 patients (678 men and 628 women) who had serum TT and SHBG measurements and were free of cardiovascular disease or cancer at baseline (2006-2010). Main outcome measures: The death cases of COVID-19 were identified from National Health Service death records updated at 31 July 2020. Unconditional logistic regression was performed to estimate the odds ratio (OR) and 95% confidence intervals (CI) for mortality. Results: We documented 315 deaths of COVID-19 (194 men and 121 women). After adjusting for potential confounders, we did not find any statistically significant associations for TT (OR per 1-SD increase = 1.03, 95% CI: 0.85-1.25), FT (OR per 1-SD increase = 0.95, 95% CI: 0.77-1.17), or SHBG (OR per 1-SD increase = 1.09, 95% CI: 0.87-1.37) with COVID-19 mortality in men. Similar null results were observed in women (TT: OR per 1-SD increase = 1.10, 95% CI: 0.85-1.42; FT: OR per 1-SD increase = 1.10, 95% CI: 0.82-1.46; SHBG: OR per 1-SD increase = 1.16, 95% CI: 0.89-1.53). Conclusions: Our findings do not support a significant role of circulating testosterone or SHBG in COVID-19 prognosis.

Longitudinal changes in serum testosterone and sex hormone‐binding globulin in men aged 40–69 years from the UK Biobank

2021 ◽  
Author(s):  
Ross J. Marriott ◽  
Kevin Murray ◽  
Graeme J. Hankey ◽  
Laurens Manning ◽  
Girish Dwivedi ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Uk Biobank ◽  
Hormone Binding ◽  
Longitudinal Changes ◽  
The Uk
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