Time-gated and lifetime-unmixed imaging of near- and short wave infrared photoluminescence from rare-earth ion doped nanoparticles

2019 ◽  
Author(s):  
Roman Ziniuk ◽  
Artem Yakovliev ◽  
Junle Qu* ◽  
Tymish Y. Ohulchanskyy*
Keyword(s):  
Rare Earth ◽  
Short Wave ◽  
Rare Earth Ion ◽  
Short Wave Infrared

scholarly journals Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence Bioimaging and Molecular Targeting of αVβ3-Expressing Tumors

2018 ◽  
Vol 17 ◽  
pp. 153601211879913 ◽  
Author(s):  
Dominik Jan Naczynski ◽  
Jason H. Stafford ◽  
Silvan Türkcan ◽  
Cesare Jenkins ◽  
Ai Leen Koh ◽  
...  
Keyword(s):  
Rare Earth ◽  
Lymphatic Mapping ◽  
Tumor Model ◽  
Short Wave ◽  
Molecular Targeting ◽  
Photon Scattering ◽  
Tissue Penetration ◽  
Fluorescence Bioimaging ◽  
Short Wave Infrared ◽  
Rare Earth Doped

The use of short-wave infrared (SWIR) light for fluorescence bioimaging offers the advantage of reduced photon scattering and improved tissue penetration compared to traditional shorter wavelength imaging approaches. While several nanomaterials have been shown capable of generating SWIR emissions, rare-earth-doped nanoparticles (REs) have emerged as an exceptionally bright and biocompatible class of SWIR emitters. Here, we demonstrate SWIR imaging of REs for several applications, including lymphatic mapping, real-time monitoring of probe biodistribution, and molecular targeting of the αvβ3 integrin in a tumor model. We further quantified the resolution and depth penetration limits of SWIR light emitted by REs in a customized imaging unit engineered for SWIR imaging of live small animals. Our results indicate that SWIR light has broad utility for preclinical biomedical imaging and demonstrates the potential for molecular imaging using targeted REs.

FEASIBILITY OF VISIBLE SHORT-WAVE INFRARED REFLECTANCE SPECTROSCOPY TO CHARACTERIZE REGOLITH-HOSTED RARE EARTH ELEMENT MINERALIZATION

2021 ◽  
Author(s):  
Wei Tan ◽  
Xiaorong Qin ◽  
Jiacheng Liu ◽  
Mei-Fu Zhou ◽  
Hongping He ◽  
...  
Keyword(s):  
Rare Earth ◽  
Rare Earth Element ◽  
Earth Element ◽  
Short Wave ◽  
Chemical Compositions ◽  
Infrared Reflectance ◽  
Spectral Parameters ◽  
Ree Mineralization ◽  
Abrupt Changes ◽  
Short Wave Infrared

Abstract Regolith-hosted rare earth element (REE) deposits predominate global resources of heavy REEs. Regoliths are underlain by various types of igneous rocks and do not always host economically valuable deposits. Thus a feasible and convenient method is desired to identify REE mineralization in a particular regolith. This study presents a detailed visible short-wave infrared reflectance (VSWIR) spectroscopic study of the Renju regolith-hosted REE deposit, South China, to provide diagnostic parameters for targeting REE orebodies in regoliths. The results show that the spectral parameters, M794_2nd and M800_2nd, derived from the VSWIR absorption of Nd3+ at approximately 800 nm, can be effectively used to estimate the total REE concentrations in regolith profiles. M1396_2nd/M1910_2nd ratios can serve as proxies to evaluate weathering intensities in a regolith. Abrupt changes of specific spectral features related to mineral abundances, chemical compositions, and weathering intensities can be correlated with variations of protolith that formed a regolith. These VSWIR proxies are robust and can be used for exploration of regolith-hosted REE deposits.

scholarly journals Real-Time Imaging of Short-Wave Infrared Luminescence Lifetimes for Anti-counterfeiting Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Roman Ziniuk ◽  
Artem Yakovliev ◽  
Hui Li ◽  
Guanying Chen ◽  
Junle Qu ◽  
...  
Keyword(s):  
Rare Earth ◽  
Real Time ◽  
Frequency Conversion ◽  
Imaging System ◽  
Short Wave ◽  
Rare Earth Ions ◽  
High Rate ◽  
Luminescence Spectra ◽  
Real Time Imaging ◽  
Short Wave Infrared

Rare-earth doped nanoparticles (RENPs) have been widely used for anti-counterfeiting and security applications due to their light frequency conversion features: they are excited at one wavelength, and they display spectrally narrow and distinguished luminescence peaks either at shorter wavelengths (i.e., frequency/energy upconversion) or at longer wavelengths (frequency/energy downconversion). RENPs with a downconversion (DC) photoluminescence (PL) in short-wave infrared (SWIR) spectral range (~1,000–1,700 nm) have recently been introduced to anti-counterfeiting applications, allowing for multilevel protection based on PL imaging through opaque layers, due to a lesser scattering of SWIR PL emission. However, as the number and spectral positions of the discrete PL bands exhibited by rare-earth ions are well-known, it is feasible to replicate luminescence spectra from RENPs, which results in a limited anti-counterfeiting security. Alternatively, lifetime of PL from RENPs can be used for encoding, as it can be finely tuned in broad temporal range (i.e., from microseconds to milliseconds) by varying type of dopants and their content in RENPs, along with the nanoparticle morphology and size. Nevertheless, the current approach to decoding and imaging the RENP luminescence lifetimes requires multiple steps and is highly time-consuming, precluding practical applications of PL lifetime encoding for anti-counterfeiting. Herein, we report the use of a rapid lifetime determination (RLD) technique to overcome this issue and introduce real-time imaging of SWIR PL lifetime for anti-counterfeiting applications. NaYF4:20% Yb, x% Er (x = 0, 2, 20, 80)@NaYF4 core@shell RENPs were synthesized and characterized, revealing DC PL in SWIR region, with maximum at ~1,530 nm and PL lifetimes ranging from 3.2 to 6 ms. Imaging of the nanoparticles with different lifetimes was performed by the developed time-gated imaging system engaging RLD method and the precise manipulation of the delay between the excitation pulses and camera gating windows. Moreover, it is shown that imaging and decrypting can be performed at a high rate (3–4 fps) in a cyclic manner, thus allowing for real-time temporal decoding. We believe that the demonstrated RLD-based fast PL lifetime imaging approach can be employed in other applications of photoluminescent RENPs.

Rare-earth doped nanocomposites enable multiscale targeted short-wave infrared imaging of metastatic breast cancer

2017 ◽  
Author(s):  
Mark C. Pierce ◽  
Laura M. Higgins ◽  
Vidya Ganapathy ◽  
Harini Kantamneni ◽  
Richard E. Riman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rare Earth ◽  
Metastatic Breast Cancer ◽  
Infrared Imaging ◽  
Metastatic Breast ◽  
Short Wave ◽  
Short Wave Infrared ◽  
Rare Earth Doped

scholarly journals Temperature Sensing in the Short-Wave Infrared Spectral Region Using Core-Shell NaGdF4:Yb3+, Ho3+, Er3+@NaYF4 Nanothermometers

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1992
Author(s):  
Daria Pominova ◽  
Vera Proydakova ◽  
Igor Romanishkin ◽  
Anastasia Ryabova ◽  
Sergei Kuznetsov ◽  
...  
Keyword(s):  
Rare Earth ◽  
Spectral Region ◽  
Thermal Sensitivity ◽  
Short Wave ◽  
Temperature Sensing ◽  
Rare Earth Ions ◽  
Core Shell ◽  
Dry Powder ◽  
Shell Nanoparticles ◽  
Short Wave Infrared

The short-wave infrared region (SWIR) is promising for deep-tissue visualization and temperature sensing due to higher penetration depth and reduced scattering of radiation. However, the strong quenching of luminescence in biological media and low thermal sensitivity of nanothermometers in this region are major drawbacks that limit their practical application. Nanoparticles doped with rare-earth ions are widely used as thermal sensors operating in the SWIR region through the luminescence intensity ratio (LIR) approach. In this study, the effect of the shell on the sensitivity of temperature determination using NaGdF4 nanoparticles doped with rare-earth ions (REI) Yb3+, Ho3+, and Er3+ coated with an inert NaYF4 shell was investigated. We found that coating the nanoparticles with a shell significantly increases the intensity of luminescence in the SWIR range, prevents water from quenching luminescence, and decreases the temperature of laser-induced heating. Thermometry in the SWIR spectral region was demonstrated using synthesized nanoparticles in dry powder and in water. The core-shell nanoparticles obtained had intense luminescence and made it possible to determine temperatures in the range of 20–40 °C. The relative thermal sensitivity of core-shell NPs was 0.68% °C−1 in water and 4.2% °C−1 in dry powder.

scholarly journals Structure, Luminescence, and Magnetic Properties of Crystalline Manganese Tungstate Doped with Rare Earth Ion

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3717
Author(s):  
Jae-Young Jung ◽  
Soung-Soo Yi ◽  
Dong-Hyun Hwang ◽  
Chang-Sik Son
Keyword(s):  
Magnetic Field ◽  
Rare Earth ◽  
Sintering Temperature ◽  
Luminescent Properties ◽  
Concentration Quenching ◽  
Rare Earth Ions ◽  
Precipitation Method ◽  
Rare Earth Ion ◽  
Co Precipitation ◽  
Quenching Phenomenon

The precursor prepared by co-precipitation method was sintered at various temperatures to synthesize crystalline manganese tungstate (MnWO4). Sintered MnWO4 showed the best crystallinity at a sintering temperature of 800 °C. Rare earth ion (Dysprosium; Dy3+) was added when preparing the precursor to enhance the magnetic and luminescent properties of crystalline MnWO4 based on these sintering temperature conditions. As the amount of rare earth ions was changed, the magnetic and luminescent characteristics were enhanced; however, after 0.1 mol.%, the luminescent characteristics decreased due to the concentration quenching phenomenon. In addition, a composite was prepared by mixing MnWO4 powder, with enhanced magnetism and luminescence properties due to the addition of dysprosium, with epoxy. To one of the two prepared composites a magnetic field was applied to induce alignment of the MnWO4 particles. Aligned particles showed stronger luminescence than the composite sample prepared with unsorted particles. As a result of this, it was suggested that it can be used as phosphor and a photosensitizer by utilizing the magnetic and luminescent properties of the synthesized MnWO4 powder with the addition of rare earth ions.

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