Rare-earth doped nanocomposites enable multiscale targeted short-wave infrared imaging of metastatic breast cancer

2017 ◽  
Author(s):  
Mark C. Pierce ◽  
Laura M. Higgins ◽  
Vidya Ganapathy ◽  
Harini Kantamneni ◽  
Richard E. Riman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rare Earth ◽  
Metastatic Breast Cancer ◽  
Infrared Imaging ◽  
Metastatic Breast ◽  
Short Wave ◽  
Short Wave Infrared ◽  
Rare Earth Doped

scholarly journals Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence Bioimaging and Molecular Targeting of αVβ3-Expressing Tumors

2018 ◽  
Vol 17 ◽  
pp. 153601211879913 ◽  
Author(s):  
Dominik Jan Naczynski ◽  
Jason H. Stafford ◽  
Silvan Türkcan ◽  
Cesare Jenkins ◽  
Ai Leen Koh ◽  
...  
Keyword(s):  
Rare Earth ◽  
Lymphatic Mapping ◽  
Tumor Model ◽  
Short Wave ◽  
Molecular Targeting ◽  
Photon Scattering ◽  
Tissue Penetration ◽  
Fluorescence Bioimaging ◽  
Short Wave Infrared ◽  
Rare Earth Doped

The use of short-wave infrared (SWIR) light for fluorescence bioimaging offers the advantage of reduced photon scattering and improved tissue penetration compared to traditional shorter wavelength imaging approaches. While several nanomaterials have been shown capable of generating SWIR emissions, rare-earth-doped nanoparticles (REs) have emerged as an exceptionally bright and biocompatible class of SWIR emitters. Here, we demonstrate SWIR imaging of REs for several applications, including lymphatic mapping, real-time monitoring of probe biodistribution, and molecular targeting of the αvβ3 integrin in a tumor model. We further quantified the resolution and depth penetration limits of SWIR light emitted by REs in a customized imaging unit engineered for SWIR imaging of live small animals. Our results indicate that SWIR light has broad utility for preclinical biomedical imaging and demonstrates the potential for molecular imaging using targeted REs.

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