Strategies for translating fluorescence imaging agents for intraoperative surgical guidance with qualified devices (Conference Presentation)

2019 ◽  
Author(s):  
Eva M. Sevick-Muraca ◽  
Banghe Zhu
Keyword(s):  
Fluorescence Imaging ◽  
Imaging Agents ◽  
Surgical Guidance

Synthesis and evaluation of new salicylaldehyde-2-picolinylhydrazone Schiff base compounds of Ru(II), Rh(III) and Ir(III) as in vitro antitumor, antibacterial and fluorescence imaging agents

2015 ◽  
Vol 20 (4) ◽  
pp. 619-638 ◽  
Author(s):  
Narasinga Rao Palepu ◽  
S. L. Nongbri ◽  
J. Richard Premkumar ◽  
Akalesh Kumar Verma ◽  
Kaushik Bhattacharjee ◽  
...  
Keyword(s):  
Schiff Base ◽  
Fluorescence Imaging ◽  
Imaging Agents

scholarly journals The development of peptide–boron difluoride formazanate conjugates as fluorescence imaging agents

RSC Advances ◽  
2020 ◽  
Vol 10 (32) ◽  
pp. 18970-18977
Author(s):  
Neha Sharma ◽  
Stephanie M. Barbon ◽  
Tyler Lalonde ◽  
Ryan R. Maar ◽  
Mark Milne ◽  
...  
Keyword(s):  
Fluorescence Microscopy ◽  
Fluorescence Imaging ◽  
Cancer Imaging ◽  
Imaging Agents ◽  
Receptor Targeting ◽  
Boron Difluoride

Conjugation of a boron difluoride formazanate dye to receptor targeting peptides provides cancer imaging agents for fluorescence microscopy.

scholarly journals Fluorescence Imaging/Agents in Tumor Resection

2017 ◽  
Vol 28 (4) ◽  
pp. 569-583 ◽  
Author(s):  
Walter Stummer ◽  
Eric Suero Molina
Keyword(s):  
Fluorescence Imaging ◽  
Tumor Resection ◽  
Imaging Agents

Quantitative imaging of lymph function

2007 ◽  
Vol 292 (6) ◽  
pp. H3109-H3118 ◽  
Author(s):  
Ruchi Sharma ◽  
Wei Wang ◽  
John C. Rasmussen ◽  
Amit Joshi ◽  
Jessica P. Houston ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Quantitative Imaging ◽  
Imaging Agents ◽  
Excitation Light ◽  
Lymph Vessels ◽  
Intradermal Administration ◽  
Nir Fluorescence ◽  
Lymph Endothelium ◽  
Lymphatic Imaging

Functional lymphatic imaging was demonstrated in the abdomen and anterior hindlimb of anesthetized, intact Yorkshire swine by using near-infrared (NIR) fluorescence imaging following intradermal administration of 100–200 μl of 32 μM indocyanine green (ICG) and 64 μM hyaluronan NIR imaging conjugate to target the lymph vacular endothelial receptor (LYVE)-1 on the lymph endothelium. NIR fluorescence imaging employed illumination of 780 nm excitation light (∼2 mW/cm2) and collection of 830 nm fluorescence generated from the imaging agents. Our results show the ability to image the immediate trafficking of ICG from the plexus, through the vessels and lymphangions, and to the superficial mammary, subiliac, and middle iliac lymph nodes, which were located as deep as 3 cm beneath the tissue surface. “Packets” of ICG-transited lymph vessels of 2–16 cm length propelled at frequencies of 0.5–3.3 pulses/min and velocities of 0.23–0.75 cm/s. Lymph propulsion was independent of respiration rate. In the case of the hyaluronan imaging agent, lymph propulsion was absent as the dye progressed immediately through the plexus and stained the lymph vessels and nodes. Lymph imaging required 5.0 and 11.9 μg of ICG and hyaluronan conjugate, respectively. Our results suggest that microgram quantities of NIR optical imaging agents and their conjugates have a potential to image lymph function in patients suffering from lymph-related disorders.

Discovery of Novel Phenaleno Isoquinolinium-Based Fluorescence Imaging Agents for Sentinel Lymph Node Mapping

2021 ◽  
Author(s):  
Ye Ri Han ◽  
Da Sol Lee ◽  
Sang Bong Lee ◽  
Hui-Jeon Jeon ◽  
Sijoon Lee ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Fluorescence Imaging ◽  
Sentinel Lymph Node Mapping ◽  
Imaging Agents ◽  
Lymph Node Mapping ◽  
Disease Diagnostics ◽  
Synthetic Routes

Fluorescence imaging agents have recently received huge attention due to their important role in disease diagnostics. However, the intrinsic problems of these probes, such as complex synthetic routes and high...

scholarly journals Carbon Dots as Nontoxic and High-Performance Fluorescence Imaging Agents

2009 ◽  
Vol 113 (42) ◽  
pp. 18110-18114 ◽  
Author(s):  
Sheng-Tao Yang ◽  
Xin Wang ◽  
Haifang Wang ◽  
Fushen Lu ◽  
Pengju G. Luo ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Carbon Dots ◽  
High Performance ◽  
Imaging Agents

scholarly journals Boronic acids for fluorescence imaging of carbohydrates

2016 ◽  
Vol 52 (17) ◽  
pp. 3456-3469 ◽  
Author(s):  
Xiaolong Sun ◽  
Wenlei Zhai ◽  
John S. Fossey ◽  
Tony D. James
Keyword(s):  
Fluorescence Imaging ◽  
Boronic Acids ◽  
Pivotal Role ◽  
Imaging Agents

Carbohydrate biomarkers are particularly important targets for fluorescence imaging given their pivotal role in numerous important biological events. This review highlights the development of fluorescence imaging agents based on boronic acids.

scholarly journals Dual in vivo Photoacoustic and Fluorescence Imaging of HER2 Expression in Breast Tumors for Diagnosis, Margin Assessment, and Surgical Guidance

2015 ◽  
Vol 14 (1) ◽  
pp. 7290.2014.00043 ◽  
Author(s):  
Azusa Maeda ◽  
Jiachuan Bu ◽  
Juan Chen ◽  
Gang Zheng ◽  
Ralph S. DaCosta
Keyword(s):  
Fluorescence Imaging ◽  
Breast Tumors ◽  
Her2 Expression ◽  
Margin Assessment ◽  
Surgical Guidance
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