Design optimization of a single-mode microring resonator for label-free detection of biomarkers within a tunable spectral range of 2 nm

2018 ◽  
Author(s):  
N.S. Susan Mousavi ◽  
Prabodh Panindre ◽  
Sunil Kumar
Keyword(s):  
Design Optimization ◽  
Spectral Range ◽  
Single Mode ◽  
Microring Resonator ◽  
Label Free ◽  
Label Free Detection ◽  
Detection Of Biomarkers

scholarly journals Detection of Biomarkers Using LSPR Substrate with Gold Nanoparticle Array

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Young Min Bae ◽  
Seung Oh Jin ◽  
Insoo Kim ◽  
Ki Young Shin ◽  
Duchang Heo ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Nanoparticle Array ◽  
Label Free ◽  
Short Analysis Time ◽  
Label Free Detection ◽  
Lift Off ◽  
Detection Of Biomarkers ◽  
The Cost

In the biosensing platform, label-free detection technique provides advantages such as the short analysis time and the cost-effectiveness. In this study, we showed the feasibility of the LSPR substrate with gold nanoparticle array for detecting low density lipoprotein (LDL) and high density lipoprotein (HDL) without labeling. The LSPR substrate was fabricated through the lift-off process with the anodized alumina mask, and its LSPR phenomenon was observed by measuring the optical transmission of substrate. The antibodies were immobilized on the gold nanoparticle array via the chemical binding, in which the 11-MUA was used as the linker to bind the antibodies. The binding of antibodies was confirmed by observing the shift of LSPR peak of the substrate. Finally, with the LSPR substrates with the antibodies immobilized, the detection of LDL and HDL was investigated. As a result, LDL and HDL could be detected in the clinically available concentration range, respectively.

scholarly journals Multi-spot, Label-free Detection of Biomarkers in Complex Media by Reflectionless Surfaces

2014 ◽  
Vol 87 ◽  
pp. 58-61
Author(s):  
M. Salina ◽  
F. Giavazzi ◽  
E. Ceccarello ◽  
F. Damin ◽  
M. Chiari ◽  
...  
Keyword(s):  
Label Free ◽  
Complex Media ◽  
Label Free Detection ◽  
Detection Of Biomarkers

Carbon Nanotubes for the Label-Free Detection of Biomarkers

ACS Nano ◽  
2013 ◽  
Vol 7 (9) ◽  
pp. 7448-7453 ◽  
Author(s):  
Alexandra M. Münzer ◽  
Zachary P. Michael ◽  
Alexander Star
Keyword(s):  
Carbon Nanotubes ◽  
Label Free ◽  
Label Free Detection ◽  
Detection Of Biomarkers

Electrochemical Microfluidic Paper-Based Aptasensor Platform Based on a Biotin–Streptavidin System for Label-Free Detection of Biomarkers

2021 ◽  
Vol 13 (39) ◽  
pp. 46317-46324
Author(s):  
Tao Ming ◽  
Yan Cheng ◽  
Yu Xing ◽  
Jinping Luo ◽  
Gang Mao ◽  
...  
Keyword(s):  
Label Free ◽  
Label Free Detection ◽  
Detection Of Biomarkers

scholarly journals The Role of Surface Chemistry in the Efficacy of Protein and DNA Microarrays for Label-Free Detection: An Overview

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1026
Author(s):  
Elisa Chiodi ◽  
Allison M. Marn ◽  
Matthew T. Geib ◽  
M. Selim Ünlü
Keyword(s):  
Surface Chemistry ◽  
Surface Functionalization ◽  
Dna Microarrays ◽  
Label Free ◽  
Polymeric Coatings ◽  
Label Free Detection ◽  
Particle Imaging ◽  
Single Particle Imaging ◽  
The Impact

The importance of microarrays in diagnostics and medicine has drastically increased in the last few years. Nevertheless, the efficiency of a microarray-based assay intrinsically depends on the density and functionality of the biorecognition elements immobilized onto each sensor spot. Recently, researchers have put effort into developing new functionalization strategies and technologies which provide efficient immobilization and stability of any sort of molecule. Here, we present an overview of the most widely used methods of surface functionalization of microarray substrates, as well as the most recent advances in the field, and compare their performance in terms of optimal immobilization of the bioreceptor molecules. We focus on label-free microarrays and, in particular, we aim to describe the impact of surface chemistry on two types of microarray-based sensors: microarrays for single particle imaging and for label-free measurements of binding kinetics. Both protein and DNA microarrays are taken into consideration, and the effect of different polymeric coatings on the molecules’ functionalities is critically analyzed.

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