Imaging biomarker development based on microbubble perfusion and oxygen saturation in a rat model of liver cancer

2018 ◽  
Author(s):  
Richard Bouchard ◽  
Mohamed Naser ◽  
Nina Gonzalez Munoz ◽  
Houra Taghavi ◽  
Kiersten Maldonado ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Oxygen Saturation ◽  
Rat Model ◽  
Imaging Biomarker

scholarly journals Erzhu Jiedu decoction ameliorates liver precancerous lesions in a rat model of liver cancer

2020 ◽  
Vol 11 (24) ◽  
pp. 7302-7311
Author(s):  
Yang Cheng ◽  
Tianyang Chen ◽  
Jianjie Chen
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Precancerous Lesions

scholarly journals Norepinephrine Transporter Imaging in the Brain of a Rat Model of Depression Using Radioiodinated (2S, αS)-2-(α-(2-iodophenoxy)benzyl)morpholine

2012 ◽  
Vol 11 (4) ◽  
pp. 7290.2011.00049 ◽  
Author(s):  
Naoki Kanegawa ◽  
Yasushi Kiyono ◽  
Taku Sugitaa ◽  
Yuji Kuge ◽  
Yasushisa Fujibayasi ◽  
...  
Keyword(s):  
Rat Model ◽  
Thalamic Nucleus ◽  
Ex Vivo ◽  
Norepinephrine Transporter ◽  
Diagnostic Information ◽  
Brain Diseases ◽  
Imaging Biomarker ◽  
Control Group ◽  
The Brain

To visualize the norepinephrine transporters (NETs) in various brain diseases, we developed radioiodinated (2S,αS)-2-(α-(2-iodophenoxy)benzyl)morpholine ((S,S)-IPBM). This radioligand achieved the basic requirements for NET imaging. In this study, we assessed the potential of radioiodinated (S,S)-IPBM as an imaging biomarker of NET to obtain diagnostic information about depression in relation to NET expression in the brain using a rat depression model. The ex vivo autoradiographic experiments using the (S,S)-[125I]IPBM showed significantly lower accumulation of radioactivity in the locus coeruleus (LC) and the anteroventricular thalamic nucleus (AVTN) of the depression group than in those of the control group. Consequently, in vitro autoradiographic experiments showed that NET maximum binding (Bmax) values in the LC and AVTN, known as NET-rich regions, were significantly decreased in the rat model of depression when compared to those of the control rats. In addition, there was an extremely good correlation between NET Bmax and (S,S)-IPBM accumulation ( r = .98), an indication of radioiodinated IPBM as a quantitative NET imaging biomarker. The reduction in(S,S)-[125I]IPBM accumulation in the rat model of depression correlated with that of NET density. These results suggest that (S,S)-[123I]IPBM has potential as an imaging biomarker of NET to obtain diagnostic information about major depression.

scholarly journals Use of Multiphoton Microscopy to Diagnose Liver Cancer and Lung Metastasis in an Orthotopic Rat Model

Scanning ◽  
2012 ◽  
Vol 34 (4) ◽  
pp. 271-277 ◽  
Author(s):  
Jun Yan ◽  
Shuangmu Zhuo ◽  
Gang Chen ◽  
Changjun Tan ◽  
Weifeng Zhu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Lung Metastasis ◽  
Rat Model ◽  
Multiphoton Microscopy

Erythropoietin improves cardiac wasting and outcomes in a rat model of liver cancer cachexia

2016 ◽  
Vol 218 ◽  
pp. 312-317 ◽  
Author(s):  
Masakazu Saitoh ◽  
Michiyoshi Hatanaka ◽  
Masaaki Konishi ◽  
Junichi Ishida ◽  
Sandra Palus ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Cancer Cachexia

Effects of Lycopene and Sho-saiko-to on Hepatocarcinogenesis in a Rat Model of Spontaneous Liver Cancer

2001 ◽  
Vol 39 (1) ◽  
pp. 96-101 ◽  
Author(s):  
Seishiro Watanabe ◽  
Yukihiro Kitade ◽  
Tsutomu Masaki ◽  
Mikio Nishioka ◽  
Kimihiko Satoh ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model

scholarly journals Hepatoprotective effects of limb ischemic post-conditioning in hepatic ischemic rat model and liver cancer patients via PI3K/ERK pathways

2018 ◽  
Vol 14 (14) ◽  
pp. 2037-2050 ◽  
Author(s):  
Yanfeng Gao ◽  
Shuang Zhou ◽  
Fengfei Wang ◽  
Yue Zhou ◽  
Sen Sheng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Patients ◽  
Rat Model ◽  
Hepatoprotective Effects

scholarly journals Spontaneous Tumor Regression in a Syngeneic Rat Model of Liver Cancer: Implications for Survival Studies

2012 ◽  
Vol 23 (12) ◽  
pp. 1685-1691 ◽  
Author(s):  
Manon Buijs ◽  
Jean-Francois H. Geschwind ◽  
Labiq H. Syed ◽  
Shanmugasundaram Ganapathy-Kanniappan ◽  
Rani Kunjithapatham ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Tumor Regression ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Regression ◽  
Survival Studies

scholarly journals Resuscitation with Lipid versus  Epinephrine in a Rat Model of Bupivacaine Overdose

2008 ◽  
Vol 108 (5) ◽  
pp. 907-913 ◽  
Author(s):  
Guy L. Weinberg ◽  
Guido Di Gregorio ◽  
Richard Ripper ◽  
Kemba Kelly ◽  
Malek Massad ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Local Anesthetic ◽  
Rat Model ◽  
Lipid Emulsion ◽  
Central Venous Oxygen Saturation ◽  
Rate Pressure Product ◽  
Saline Control ◽  
Chest Compressions ◽  
Central Venous ◽  
Venous Oxygen Saturation

Background Lipid emulsion infusion reverses cardiovascular compromise due to local anesthetic overdose in laboratory and clinical settings. The authors compared resuscitation with lipid, epinephrine, and saline control in a rat model of bupivacaine-induced cardiac toxicity to determine whether lipid provides a benefit over epinephrine. Methods Bupivacaine, 20 mg/kg, was infused in rats anesthetized with isoflurane, producing asystole in all subjects. Ventilation with 100% oxygen and chest compressions were begun immediately, along with intravenous treatment with 30% lipid emulsion or saline (5-ml/kg bolus plus continuous infusion at 0.5 ml . kg . min) or epinephrine (30 microg/kg). Chest compressions were continued and boluses were repeated at 2.5 and 5 min until the native rate-pressure product was greater than 20% baseline. Electrocardiogram and arterial pressure were monitored continuously and at 10 min, arterial blood gas, central venous oxygen saturation, and blood lactate were measured. Effect size (Cohen d) was determined for comparisons at 10 min. Results Lipid infusion resulted in higher rate-pressure product (P < 0.001, d = 3.84), pH (P < 0.01, d = 3.78), arterial oxygen tension (P < 0.05, d = 2.8), and central venous oxygen saturation (P < 0.001, d = 4.9) at 10 min than did epinephrine. Epinephrine treatment caused higher lactate (P < 0.01, d = 1.48), persistent ventricular ectopy in all subjects, pulmonary edema in four of five rats, hypoxemia, and a mixed metabolic and respiratory acidosis by 10 min. Conclusions Hemodynamic and metabolic metrics during resuscitation with lipid surpassed those with epinephrine, which were no better than those seen in the saline control group. Further studies are required to optimize the clinical management of systemic local anesthetic toxicity.

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