Hepatic toxicity and compensatory hyperplasia in a rat model of aflatoxin bi-induced liver cancer

1996 ◽  
Author(s):  
Yulia Y. Maxuitenko
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Hepatic Toxicity

scholarly journals Erzhu Jiedu decoction ameliorates liver precancerous lesions in a rat model of liver cancer

2020 ◽  
Vol 11 (24) ◽  
pp. 7302-7311
Author(s):  
Yang Cheng ◽  
Tianyang Chen ◽  
Jianjie Chen
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Precancerous Lesions

scholarly journals Use of Multiphoton Microscopy to Diagnose Liver Cancer and Lung Metastasis in an Orthotopic Rat Model

Scanning ◽  
2012 ◽  
Vol 34 (4) ◽  
pp. 271-277 ◽  
Author(s):  
Jun Yan ◽  
Shuangmu Zhuo ◽  
Gang Chen ◽  
Changjun Tan ◽  
Weifeng Zhu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Lung Metastasis ◽  
Rat Model ◽  
Multiphoton Microscopy

Erythropoietin improves cardiac wasting and outcomes in a rat model of liver cancer cachexia

2016 ◽  
Vol 218 ◽  
pp. 312-317 ◽  
Author(s):  
Masakazu Saitoh ◽  
Michiyoshi Hatanaka ◽  
Masaaki Konishi ◽  
Junichi Ishida ◽  
Sandra Palus ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Cancer Cachexia

Effects of Lycopene and Sho-saiko-to on Hepatocarcinogenesis in a Rat Model of Spontaneous Liver Cancer

2001 ◽  
Vol 39 (1) ◽  
pp. 96-101 ◽  
Author(s):  
Seishiro Watanabe ◽  
Yukihiro Kitade ◽  
Tsutomu Masaki ◽  
Mikio Nishioka ◽  
Kimihiko Satoh ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model

scholarly journals Hepatoprotective effects of limb ischemic post-conditioning in hepatic ischemic rat model and liver cancer patients via PI3K/ERK pathways

2018 ◽  
Vol 14 (14) ◽  
pp. 2037-2050 ◽  
Author(s):  
Yanfeng Gao ◽  
Shuang Zhou ◽  
Fengfei Wang ◽  
Yue Zhou ◽  
Sen Sheng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Patients ◽  
Rat Model ◽  
Hepatoprotective Effects

scholarly journals Spontaneous Tumor Regression in a Syngeneic Rat Model of Liver Cancer: Implications for Survival Studies

2012 ◽  
Vol 23 (12) ◽  
pp. 1685-1691 ◽  
Author(s):  
Manon Buijs ◽  
Jean-Francois H. Geschwind ◽  
Labiq H. Syed ◽  
Shanmugasundaram Ganapathy-Kanniappan ◽  
Rani Kunjithapatham ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Tumor Regression ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Regression ◽  
Survival Studies

scholarly journals OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Jinhua Wen ◽  
Menghua Zhao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cell Viability ◽  
Rat Model ◽  
Hepg2 Cells ◽  
Genetic Mutations ◽  
Control Group ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Sorafenib Treatment ◽  
Apoptosis Rate

Background. Sorafenib is an anticancer drug used in the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. It is a substrate for the human OATP1B1. This study is aimed at assessing the role of OATP1B1 in transportation and uptake of sorafenib in hepatocellular carcinoma and how OATP1B1 affects the pharmacodynamics of sorafenib in vitro and in vivo. Methods. Sorafenib transport was measured in HepG2, HepG2-OATP1B1 ∗ 1a, HepG2-OATP1B1 ∗ 1b, HepG2-OATP1B1 ∗ 15, LO2, LO2-OATP1B1 ∗ 1a, LO2-OATP1B1 ∗ 1b, and LO2-OATP1B1 ∗ 15 cells, as well as in HepG2 cells transfected with miR-148a mimics. The viability and apoptosis rate of cells treated with sorafenib were evaluated. A liver cancer rat model was established to explore the pharmacokinetics and pharmacodynamics of sorafenib after overexpression of Oatp2. Results. Changes in expression and genetic mutations of OATP1B1 significantly affected the uptake of sorafenib in HepG2 and LO2 transgenic cells, and the uptake of sorafenib was higher in HepG2 than LO2. Genetic mutations of OATP1B1 significantly affected the cell viability and apoptosis rate of HepG2 cells after sorafenib treatment. Compared to control group, the uptake of sorafenib in miR-148a mimic-transfected HepG2 cells was decreased, and the cell viability was increased. PCN significantly increased the expression of Oatp2 and affected the pharmacokinetics of sorafenib. Vascular endothelial growth factor levels and microvascular density in tumor-adjacent tissues decreased significantly, suggesting that increased Oatp2 expression improves the treatment effect of sorafenib in a rat model of liver cancer. Conclusions. OATP1B1 plays an important role in the pharmacokinetics and pharmacodynamics of sorafenib in hepatocellular carcinoma.

scholarly journals Establishment of an Immunocompetent Metastasis Rat Model with Hepatocyte Cancer Stem Cells

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3721
Author(s):  
Semon Wu ◽  
I-Chieh Tseng ◽  
Wen-Cheng Huang ◽  
Cheng-Wen Su ◽  
Yu-Heng Lai ◽  
...  
Keyword(s):  
Machine Learning ◽  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Genetic Markers ◽  
Rat Model ◽  
Wild Type ◽  
Rat Models ◽  
Highly Expressed Genes

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality. Cancer stem cells (CSCs) are responsible for the maintenance, metastasis, and relapse of various tumors. The effects of CSCs on the tumorigenesis of HCC are still not fully understood, however. We have recently established two new rat HCC cell lines HTC and TW-1, which we isolated from diethylnitrosamine-induced rat liver cancer. Results showed that TW-1 expressed the genetic markers of CSCs, including CD133, GSTP1, CD44, CD90, and EpCAM. Moreover, TW-1 showed higher tolerance to sorafenib than HTC did. In addition, tumorigenesis and metastasis were observed in nude mice and wild-type rats with TW-1 xenografts. Finally, we combined highly expressed genes in TW-1/HTC with well-known biomarkers from recent HCC studies to predict HCC-related biomarkers and able to identify HCC with AUCs > 0.9 after machine learning. These results indicated that TW-1 was a novel rat CSC line, and the mice or rat models we established with TW-1 has great potential on HCC studies in the future.

A Rat Model of Liver Cancer for Imaging Research

1987 ◽  
Vol 22 (2) ◽  
pp. 149-152 ◽  
Author(s):  
SANJAY SAINI ◽  
DAVID D. STARK ◽  
JACK WITTENBERG ◽  
LUIS-GASTON VICI ◽  
ALAN S. BROWN ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Imaging Research
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