scholarly journals Erzhu Jiedu decoction ameliorates liver precancerous lesions in a rat model of liver cancer

2020 ◽  
Vol 11 (24) ◽  
pp. 7302-7311
Author(s):  
Yang Cheng ◽  
Tianyang Chen ◽  
Jianjie Chen
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Precancerous Lesions

scholarly journals Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Guolin Ma ◽  
Rongjie Bai ◽  
Huijie Jiang ◽  
Xuejia Hao ◽  
Zaisheng Ling ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Rat Model ◽  
Ct Perfusion ◽  
Precancerous Lesions ◽  
Mean Transit Time ◽  
Ct Scanning ◽  
Spiral Ct ◽  
Control Group ◽  
Hemodynamic Changes ◽  
Multislice Spiral Ct

Rationale and Objectives. To develop an optimal scanning protocol for multislice spiral CT perfusion (CTP) imaging to evaluate hemodynamic changes in liver cirrhosis with diethylnitrosamine- (DEN-) induced precancerous lesions.Materials and Methods. Male Wistar rats were randomly divided into the control group (n=80) and the precancerous liver cirrhosis group (n=40). The control group received saline injection and the liver cirrhosis group received 50 mg/kg DENi.p.twice a week for 12 weeks. All animals underwent plain CT scanning, CTP, and contrast-enhanced CT scanning. Scanning parameters were optimized by adjusting the diatrizoate concentration, the flow rate, and the delivery time. The hemodynamics of both groups was further compared using optimized multislice spiral CTP imaging.Results. High-quality CTP images were obtained with following parameters: 150 kV; 150 mAs; 5 mm thickness, 5 mm interval; pitch, 1; matrix,512×512; and FOV, 9.6 cm. Compared to the control group, the liver cirrhosis group had a significantly increased value of the hepatic arterial fraction and the hepatic artery perfusion (P<0.05) but significantly decreased hepatic portal perfusion and mean transit time (P<0.05).Conclusion. Multislice spiral CTP imaging can be used to evaluate the hemodynamic changes in the rat model of liver cirrhosis with precancerous lesions.

scholarly journals Use of Multiphoton Microscopy to Diagnose Liver Cancer and Lung Metastasis in an Orthotopic Rat Model

Scanning ◽  
2012 ◽  
Vol 34 (4) ◽  
pp. 271-277 ◽  
Author(s):  
Jun Yan ◽  
Shuangmu Zhuo ◽  
Gang Chen ◽  
Changjun Tan ◽  
Weifeng Zhu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Lung Metastasis ◽  
Rat Model ◽  
Multiphoton Microscopy

Erythropoietin improves cardiac wasting and outcomes in a rat model of liver cancer cachexia

2016 ◽  
Vol 218 ◽  
pp. 312-317 ◽  
Author(s):  
Masakazu Saitoh ◽  
Michiyoshi Hatanaka ◽  
Masaaki Konishi ◽  
Junichi Ishida ◽  
Sandra Palus ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Cancer Cachexia

Effects of Lycopene and Sho-saiko-to on Hepatocarcinogenesis in a Rat Model of Spontaneous Liver Cancer

2001 ◽  
Vol 39 (1) ◽  
pp. 96-101 ◽  
Author(s):  
Seishiro Watanabe ◽  
Yukihiro Kitade ◽  
Tsutomu Masaki ◽  
Mikio Nishioka ◽  
Kimihiko Satoh ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model

scholarly journals Hepatoprotective effects of limb ischemic post-conditioning in hepatic ischemic rat model and liver cancer patients via PI3K/ERK pathways

2018 ◽  
Vol 14 (14) ◽  
pp. 2037-2050 ◽  
Author(s):  
Yanfeng Gao ◽  
Shuang Zhou ◽  
Fengfei Wang ◽  
Yue Zhou ◽  
Sen Sheng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Patients ◽  
Rat Model ◽  
Hepatoprotective Effects

scholarly journals Spontaneous Tumor Regression in a Syngeneic Rat Model of Liver Cancer: Implications for Survival Studies

2012 ◽  
Vol 23 (12) ◽  
pp. 1685-1691 ◽  
Author(s):  
Manon Buijs ◽  
Jean-Francois H. Geschwind ◽  
Labiq H. Syed ◽  
Shanmugasundaram Ganapathy-Kanniappan ◽  
Rani Kunjithapatham ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Tumor Regression ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Regression ◽  
Survival Studies

scholarly journals OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Jinhua Wen ◽  
Menghua Zhao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cell Viability ◽  
Rat Model ◽  
Hepg2 Cells ◽  
Genetic Mutations ◽  
Control Group ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Sorafenib Treatment ◽  
Apoptosis Rate

Background. Sorafenib is an anticancer drug used in the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. It is a substrate for the human OATP1B1. This study is aimed at assessing the role of OATP1B1 in transportation and uptake of sorafenib in hepatocellular carcinoma and how OATP1B1 affects the pharmacodynamics of sorafenib in vitro and in vivo. Methods. Sorafenib transport was measured in HepG2, HepG2-OATP1B1 ∗ 1a, HepG2-OATP1B1 ∗ 1b, HepG2-OATP1B1 ∗ 15, LO2, LO2-OATP1B1 ∗ 1a, LO2-OATP1B1 ∗ 1b, and LO2-OATP1B1 ∗ 15 cells, as well as in HepG2 cells transfected with miR-148a mimics. The viability and apoptosis rate of cells treated with sorafenib were evaluated. A liver cancer rat model was established to explore the pharmacokinetics and pharmacodynamics of sorafenib after overexpression of Oatp2. Results. Changes in expression and genetic mutations of OATP1B1 significantly affected the uptake of sorafenib in HepG2 and LO2 transgenic cells, and the uptake of sorafenib was higher in HepG2 than LO2. Genetic mutations of OATP1B1 significantly affected the cell viability and apoptosis rate of HepG2 cells after sorafenib treatment. Compared to control group, the uptake of sorafenib in miR-148a mimic-transfected HepG2 cells was decreased, and the cell viability was increased. PCN significantly increased the expression of Oatp2 and affected the pharmacokinetics of sorafenib. Vascular endothelial growth factor levels and microvascular density in tumor-adjacent tissues decreased significantly, suggesting that increased Oatp2 expression improves the treatment effect of sorafenib in a rat model of liver cancer. Conclusions. OATP1B1 plays an important role in the pharmacokinetics and pharmacodynamics of sorafenib in hepatocellular carcinoma.

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