Image-guided urologic surgery: intraoperative optical imaging and tissue interrogation (Conference Presentation)

2017 ◽  
Author(s):  
Joseph C. Liao
Keyword(s):  
Optical Imaging ◽  
Urologic Surgery ◽  
Image Guided

scholarly journals Dual-mode optical imaging system for fluorescence image-guided surgery

2014 ◽  
Vol 39 (13) ◽  
pp. 3830 ◽  
Author(s):  
Nan Zhu ◽  
Suman Mondal ◽  
Shengkui Gao ◽  
Samuel Achilefua ◽  
Viktor Gruev ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Imaging System ◽  
Image Guided Surgery ◽  
Dual Mode ◽  
Fluorescence Image ◽  
Guided Surgery ◽  
Image Guided ◽  
Optical Imaging System

scholarly journals Image-guided in situ detection of bacterial biofilms in a human prosthetic knee infection model: a feasibility study for clinical diagnosis of prosthetic joint infections

2020 ◽  
Author(s):  
Jorrit W. A. Schoenmakers ◽  
Marjolein Heuker ◽  
Marina López-Álvarez ◽  
Wouter B. Nagengast ◽  
Gooitzen M. van Dam ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Bacterial Species ◽  
Bacterial Biofilms ◽  
Infection Model ◽  
Knee Infection ◽  
Prosthetic Knee ◽  
Image Guided ◽  
Prosthetic Joints ◽  
Prosthetic Joint Infections ◽  
Prosthetic Knee Infection

Abstract Purpose Due to an increased human life expectancy, the need to replace arthritic or dysfunctional joints by prosthetics is higher than ever before. Prosthetic joints are unfortunately inherently susceptible to bacterial infection accompanied by biofilm formation. Accurate and rapid diagnosis is vital to increase therapeutic success. Yet, established diagnostic modalities cannot directly detect bacterial biofilms on prostheses. Therefore, the present study was aimed at investigating whether arthroscopic optical imaging can accurately detect bacterial biofilms on prosthetic joints. Methods Here, we applied a conjugate of the antibiotic vancomycin and the near-infrared fluorophore IRDye800CW, in short vanco-800CW, in combination with arthroscopic optical imaging to target and visualize biofilms on infected prostheses. Results We show in a human post-mortem prosthetic knee infection model that a staphylococcal biofilm is accurately detected in real time and distinguished from sterile sections in high resolution. In addition, we demonstrate that biofilms associated with the clinically most relevant bacterial species can be detected using vanco-800CW. Conclusion The presented image-guided arthroscopic approach provides direct visual diagnostic information and facilitates immediate appropriate treatment selection.

Image-guided near-infrared fluorescent sentinel lymph node mapping in human breast cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11591-e11591
Author(s):  
S. Troyan ◽  
S. Gibbs-Strauss ◽  
S. Gioux ◽  
R. Oketokoun ◽  
F. Azar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Optical Imaging ◽  
Real Time ◽  
Near Infrared ◽  
Imaging System ◽  
Sulfur Colloid ◽  
Guided Surgery ◽  
Image Guided ◽  
Nir Fluorescence ◽  
Surgical Field

e11591 Background: Breast cancer surgery is presently performed without real-time image-guidance. We have developed a novel optical imaging system for image-guided surgery that uses invisible near-infrared (NIR) fluorescent light to highlight structures on the surgical field with high sensitivity, specificity, and contrast. We have also performed the first human clinical trial of the imaging system in women undergoing SLN mapping for breast cancer. Methods: We used a portable imaging system with an articulating arm that has 6 degrees of freedom, high power LED light source, custom optics, custom software, and sterile drape. The imaging system provided simultaneous and real-time imaging of color video and NIR fluorescence at up to 15 frames per second. N = 6 women with biopsy- confirmed breast cancer undergoing SLN mapping gave informed consent. All subjects received conventional mapping with Tc-99m sulfur colloid using a handheld gamma probe as well as NIR fluorescence-guided SLN mapping using a mixture of indocyanine green (ICG) diluted to a final concentration of 10 μM in human serum albumin (ICG:HSA). Results: The imaging system was easy to position in the operating room, with the articulating arm providing 50” horizontal reach and 70” vertical reach. Working distance to the patient was 18”. NIR fluorescence excitation was 20 mW/cm2 at 760 nm. NIR-depleted white light was 40,000 lux. A total of 1.6 ml of ICG:HSA was injected intra-tumorally and peri-tumorally and the site massaged for 5 min. 8 of 9 SLNs identified by Tc- 99m sulfur colloid were also identified by NIR fluorescence. However, NIR fluorescence identified an SLN, confirmed to have cancer in it, that was not identified by Tc-99m sulfur colloid. These differences were consistent with asynchrony in the injection techniques. Unlike the gamma-ray probe, NIR fluorescence provided high-resolution, large area optical imaging of the surgical field, and helped guide surgical resection. Conclusions: In this 6-patient pilot study, a novel NIR fluorescence optical imaging system was used for the first time, and provided real-time image-guided surgery for SLN mapping of breast cancer. No significant financial relationships to disclose.

Rapid optical imaging of human breast tumour xenografts using anti-HER2 VHHs site-directly conjugated to IRDye 800CW for image-guided surgery

2013 ◽  
Vol 40 (11) ◽  
pp. 1718-1729 ◽  
Author(s):  
Marta Kijanka ◽  
Frank-Jan Warnders ◽  
Mohamed El Khattabi ◽  
Marjolijn Lub-de Hooge ◽  
Gooitzen M. van Dam ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Breast Tumour ◽  
Image Guided Surgery ◽  
Human Breast ◽  
Human Breast Tumour ◽  
Guided Surgery ◽  
Image Guided ◽  
Tumour Xenografts

scholarly journals Image-guided study of swine anatomy as a tool for urologic surgery research and training

2020 ◽  
Vol 35 (12) ◽  
Author(s):  
Jacob Hindrik Antunes Smit ◽  
Eduardo Piotto Leonardi ◽  
Rosa Helena de Figueiredo Chaves ◽  
Ismari Perini Furlaneto ◽  
Cezar Massoud Salame da Silva ◽  
...  
Keyword(s):  
Urologic Surgery ◽  
Image Guided ◽  
Surgery Research ◽  
And Training

scholarly journals High contrast optical imaging methods for image guided laser ablation of dental caries lesions

2014 ◽  
Author(s):  
Nicole R. LaMantia ◽  
Henry Tom ◽  
Kenneth H. Chan ◽  
Jacob C. Simon ◽  
Cynthia L. Darling ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Dental Caries ◽  
Optical Imaging ◽  
High Contrast ◽  
Imaging Methods ◽  
Image Guided ◽  
Caries Lesions

Intraoperative optical imaging of functional brain areas for improved image-guided surgery

2013 ◽  
Vol 58 (3) ◽  
Author(s):  
Tobias Meyer ◽  
Stephan B. Sobottka ◽  
Matthias Kirsch ◽  
Gabriele Schackert ◽  
Ralf Steinmeier ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Image Guided Surgery ◽  
Brain Areas ◽  
Functional Brain ◽  
Guided Surgery ◽  
Image Guided
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