Intraoperative optical imaging of functional brain areas for improved image-guided surgery

2013 ◽  
Vol 58 (3) ◽  
Author(s):  
Tobias Meyer ◽  
Stephan B. Sobottka ◽  
Matthias Kirsch ◽  
Gabriele Schackert ◽  
Ralf Steinmeier ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Image Guided Surgery ◽  
Brain Areas ◽  
Functional Brain ◽  
Guided Surgery ◽  
Image Guided

scholarly journals Dual-mode optical imaging system for fluorescence image-guided surgery

2014 ◽  
Vol 39 (13) ◽  
pp. 3830 ◽  
Author(s):  
Nan Zhu ◽  
Suman Mondal ◽  
Shengkui Gao ◽  
Samuel Achilefua ◽  
Viktor Gruev ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Imaging System ◽  
Image Guided Surgery ◽  
Dual Mode ◽  
Fluorescence Image ◽  
Guided Surgery ◽  
Image Guided ◽  
Optical Imaging System

Rapid optical imaging of human breast tumour xenografts using anti-HER2 VHHs site-directly conjugated to IRDye 800CW for image-guided surgery

2013 ◽  
Vol 40 (11) ◽  
pp. 1718-1729 ◽  
Author(s):  
Marta Kijanka ◽  
Frank-Jan Warnders ◽  
Mohamed El Khattabi ◽  
Marjolijn Lub-de Hooge ◽  
Gooitzen M. van Dam ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Breast Tumour ◽  
Image Guided Surgery ◽  
Human Breast ◽  
Human Breast Tumour ◽  
Guided Surgery ◽  
Image Guided ◽  
Tumour Xenografts

Comparison of Functional Brain PET Images and Intraoperative Brain-Mapping Data Using Image-Guided Surgery

2002 ◽  
Vol 7 (6) ◽  
pp. 317-325 ◽  
Author(s):  
S. B. Sobottka ◽  
J. Bredow ◽  
B. Beuthien-baumann ◽  
G. Reiss ◽  
G. Schackert ◽  
...  
Keyword(s):  
Brain Mapping ◽  
Image Guided Surgery ◽  
Mapping Data ◽  
Functional Brain ◽  
Guided Surgery ◽  
Image Guided ◽  
Brain Pet

Image-guided surgery in head and neck cancer: Current practice and future directions of optical imaging

Head & Neck ◽  
2011 ◽  
Vol 34 (1) ◽  
pp. 120-126 ◽  
Author(s):  
S. Keereweer ◽  
H. J. C. M. Sterenborg ◽  
J. D. F. Kerrebijn ◽  
P. B. A. A. Van Driel ◽  
R. J. Baatenburg de Jong ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Optical Imaging ◽  
Head And Neck ◽  
Neck Cancer ◽  
Current Practice ◽  
Image Guided Surgery ◽  
Future Directions ◽  
Guided Surgery ◽  
Image Guided

Three-Dimensional Localization: From Image-Guided Surgery to Information-Guided Therapy

Methods ◽  
2001 ◽  
Vol 25 (2) ◽  
pp. 186-200 ◽  
Author(s):  
Richard D. Bucholz ◽  
Kurt R. Smith ◽  
Keith A. Laycock ◽  
Leslie L. McDurmont
Keyword(s):  
Three Dimensional ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
Guided Therapy

scholarly journals Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaojing Shi ◽  
Caiguang Cao ◽  
Zeyu Zhang ◽  
Jie Tian ◽  
Zhenhua Hu
Keyword(s):  
Fluorescent Probes ◽  
Signal Intensity ◽  
Tumor Imaging ◽  
Tumor Resection ◽  
Optical Signal ◽  
Gadolinium Oxide ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
The Impact

AbstractCerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limited by weak optical signal and restricted tissue penetration depth. Various fluorescent probes have been combined with radiopharmaceuticals for improved imaging performances. However, as most of these probes only interact with Cerenkov luminescence (CL), the low photon fluence of CL greatly restricted it’s interaction with fluorescent probes for in vivo imaging. Therefore, it is important to develop probes that can effectively convert energy beyond CL such as β and γ to the low energy optical signals. In this study, a Eu3+ doped gadolinium oxide (Gd2O3:Eu) was synthesized and combined with radiopharmaceuticals to achieve a red-shifted optical spectrum with less tissue scattering and enhanced optical signal intensity in this study. The interaction between Gd2O3:Eu and radiopharmaceutical were investigated using 18F-fluorodeoxyglucose (18F-FDG). The ex vivo optical signal intensity of the mixture of Gd2O3:Eu and 18F-FDG reached 369 times as high as that of CLI using 18F-FDG alone. To achieve improved biocompatibility, the Gd2O3:Eu nanoparticles were then modified with polyvinyl alcohol (PVA), and the resulted nanoprobe PVA modified Gd2O3:Eu (Gd2O3:Eu@PVA) was applied in intraoperative tumor imaging. Compared with 18F-FDG alone, intraoperative administration of Gd2O3:Eu@PVA and 18F-FDG combination achieved a much higher tumor-to-normal tissue ratio (TNR, 10.24 ± 2.24 vs. 1.87 ± 0.73, P = 0.0030). The use of Gd2O3:Eu@PVA and 18F-FDG also assisted intraoperative detection of tumors that were omitted by preoperative positron emission tomography (PET) imaging. Further experiment of image-guided surgery demonstrated feasibility of image-guided tumor resection using Gd2O3:Eu@PVA and 18F-FDG. In summary, Gd2O3:Eu can achieve significantly optimized imaging property when combined with 18F-FDG in intraoperative tumor imaging and image-guided tumor resection surgery. It is expected that the development of the Gd2O3:Eu nanoparticle will promote investigation and application of novel nanoparticles that can interact with radiopharmaceuticals for improved imaging properties. This work highlighted the impact of the nanoprobe that can be excited by radiopharmaceuticals emitting CL, β, and γ radiation for precisely imaging of tumor and intraoperatively guide tumor resection.

Image‐guided surgery in otolaryngology: A review of current applications and future directions in head and neck surgery

Head & Neck ◽  
2021 ◽  
Author(s):  
Sarah Y. Bessen ◽  
Xiaotian Wu ◽  
Michael T. Sramek ◽  
Yuan Shi ◽  
David Pastel ◽  
...  
Keyword(s):  
Head And Neck ◽  
Neck Surgery ◽  
Head And Neck Surgery ◽  
Image Guided Surgery ◽  
Future Directions ◽  
Guided Surgery ◽  
Image Guided
Sign in / Sign up

Export Citation Format

Share Document