scholarly journals Ultrasound tomography imaging with waveform sound speed: parenchymal changes in women undergoing tamoxifen therapy

2017 ◽  
Author(s):  
Mark Sak ◽  
Neb Duric ◽  
Peter Littrup ◽  
Mark Sherman ◽  
Gretchen Gierach
Keyword(s):  
Sound Speed ◽  
Tamoxifen Therapy ◽  
Ultrasound Tomography ◽  
Tomography Imaging

scholarly journals Using Whole Breast Ultrasound Tomography to Improve Breast Cancer Risk Assessment: A Novel Risk Factor Based on the Quantitative Tissue Property of Sound Speed

2020 ◽  
Vol 9 (2) ◽  
pp. 367 ◽  
Author(s):  
Neb Duric ◽  
Mark Sak ◽  
Shaoqi Fan ◽  
Ruth M. Pfeiffer ◽  
Peter J. Littrup ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sound Speed ◽  
Menopausal Status ◽  
Surrogate Marker ◽  
Breast Ultrasound ◽  
Ultrasound Tomography ◽  
Breast Cancer Risk Assessment

Mammographic percent density (MPD) is an independent risk factor for developing breast cancer, but its inclusion in clinical risk models provides only modest improvements in individualized risk prediction, and MPD is not typically assessed in younger women because of ionizing radiation concerns. Previous studies have shown that tissue sound speed, derived from whole breast ultrasound tomography (UST), a non-ionizing modality, is a potential surrogate marker of breast density, but prior to this study, sound speed has not been directly linked to breast cancer risk. To that end, we explored the relation of sound speed and MPD with breast cancer risk in a case-control study, including 61 cases with recent breast cancer diagnoses and a comparison group of 165 women, frequency matched to cases on age, race, and menopausal status, and with a recent negative mammogram and no personal history of breast cancer. Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the relation of quartiles of MPD and sound speed with breast cancer risk adjusted for matching factors. Elevated MPD was associated with increased breast cancer risk, although the trend did not reach statistical significance (OR per quartile = 1.27, 95% CI: 0.95, 1.70; ptrend = 0.10). In contrast, elevated sound speed was significantly associated with breast cancer risk in a dose–response fashion (OR per quartile = 1.83, 95% CI: 1.32, 2.54; ptrend = 0.0003). The OR trend for sound speed was statistically significantly different from that observed for MPD (p = 0.005). These findings suggest that whole breast sound speed may be more strongly associated with breast cancer risk than MPD and offer future opportunities for refining the magnitude and precision of risk associations in larger, population-based studies, including women younger than usual screening ages.

Ultrasound Tomography Imaging of Defects Using Neural Networks

1992 ◽  
Vol 4 (5) ◽  
pp. 758-771 ◽  
Author(s):  
Denis M. Anthony ◽  
Evor L. Hines ◽  
David A. Hutchins ◽  
J. T. Mottram
Keyword(s):  
Neural Networks ◽  
Inverse Problem ◽  
Artificial Neural Networks ◽  
Longitudinal Wave ◽  
Time Of Flight ◽  
Simplified Model ◽  
Gray Scale ◽  
Ultrasound Tomography ◽  
Tomography Imaging ◽  
Ultrasound Propagation

Simulations of ultrasound tomography demonstrated that artificial neural networks can solve the inverse problem in ultrasound tomography. A highly simplified model of ultrasound propagation was constructed, taking no account of refraction or diffraction, and using only longitudinal wave time of flight (TOF). TOF data were used as the network inputs, and the target outputs were the expected pixel maps, showing defects (gray scale coded) according to the velocity of the wave in the defect. The effects of varying resolution and defect velocity were explored. It was found that defects could be imaged using time of flight of ultrasonic rays.

Imaging of Sound Speed Using Reflection Ultrasound Tomography

2012 ◽  
Vol 31 (9) ◽  
pp. 1389-1404 ◽  
Author(s):  
Jakob Nebeker ◽  
Thomas R. Nelson
Keyword(s):  
Sound Speed ◽  
Ultrasound Tomography

scholarly journals Comparison of sound speed measurements on two different ultrasound tomography devices

2014 ◽  
Author(s):  
Mark Sak ◽  
Neb Duric ◽  
Peter Littrup ◽  
Lisa Bey-Knight ◽  
Mark Sherman ◽  
...  
Keyword(s):  
Sound Speed ◽  
Ultrasound Tomography

scholarly journals Sound speed estimation using wave-based ultrasound tomography: theory and GPU implementation

2010 ◽  
Author(s):  
O. Roy ◽  
I. Jovanović ◽  
A. Hormati ◽  
R. Parhizkar ◽  
M. Vetterli
Keyword(s):  
Sound Speed ◽  
Speed Estimation ◽  
Ultrasound Tomography ◽  
Gpu Implementation

scholarly journals Determinants of the reliability of ultrasound tomography sound speed estimates as a surrogate for volumetric breast density

2015 ◽  
Vol 42 (10) ◽  
pp. 5671-5678 ◽  
Author(s):  
Zeina G. Khodr ◽  
Mark A. Sak ◽  
Ruth M. Pfeiffer ◽  
Nebojsa Duric ◽  
Peter Littrup ◽  
...  
Keyword(s):  
Breast Density ◽  
Sound Speed ◽  
Ultrasound Tomography
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