scholarly journals Determinants of the reliability of ultrasound tomography sound speed estimates as a surrogate for volumetric breast density

2015 ◽  
Vol 42 (10) ◽  
pp. 5671-5678 ◽  
Author(s):  
Zeina G. Khodr ◽  
Mark A. Sak ◽  
Ruth M. Pfeiffer ◽  
Nebojsa Duric ◽  
Peter Littrup ◽  
...  
Keyword(s):  
Breast Density ◽  
Sound Speed ◽  
Ultrasound Tomography

scholarly journals Using Whole Breast Ultrasound Tomography to Improve Breast Cancer Risk Assessment: A Novel Risk Factor Based on the Quantitative Tissue Property of Sound Speed

2020 ◽  
Vol 9 (2) ◽  
pp. 367 ◽  
Author(s):  
Neb Duric ◽  
Mark Sak ◽  
Shaoqi Fan ◽  
Ruth M. Pfeiffer ◽  
Peter J. Littrup ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sound Speed ◽  
Menopausal Status ◽  
Surrogate Marker ◽  
Breast Ultrasound ◽  
Ultrasound Tomography ◽  
Breast Cancer Risk Assessment

Mammographic percent density (MPD) is an independent risk factor for developing breast cancer, but its inclusion in clinical risk models provides only modest improvements in individualized risk prediction, and MPD is not typically assessed in younger women because of ionizing radiation concerns. Previous studies have shown that tissue sound speed, derived from whole breast ultrasound tomography (UST), a non-ionizing modality, is a potential surrogate marker of breast density, but prior to this study, sound speed has not been directly linked to breast cancer risk. To that end, we explored the relation of sound speed and MPD with breast cancer risk in a case-control study, including 61 cases with recent breast cancer diagnoses and a comparison group of 165 women, frequency matched to cases on age, race, and menopausal status, and with a recent negative mammogram and no personal history of breast cancer. Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the relation of quartiles of MPD and sound speed with breast cancer risk adjusted for matching factors. Elevated MPD was associated with increased breast cancer risk, although the trend did not reach statistical significance (OR per quartile = 1.27, 95% CI: 0.95, 1.70; ptrend = 0.10). In contrast, elevated sound speed was significantly associated with breast cancer risk in a dose–response fashion (OR per quartile = 1.83, 95% CI: 1.32, 2.54; ptrend = 0.0003). The OR trend for sound speed was statistically significantly different from that observed for MPD (p = 0.005). These findings suggest that whole breast sound speed may be more strongly associated with breast cancer risk than MPD and offer future opportunities for refining the magnitude and precision of risk associations in larger, population-based studies, including women younger than usual screening ages.

scholarly journals Quantitative assessment of breast density using transmission ultrasound tomography

2019 ◽  
Vol 46 (6) ◽  
pp. 2610-2620 ◽  
Author(s):  
James Wiskin ◽  
Bilal Malik ◽  
Rajni Natesan ◽  
Mark Lenox
Keyword(s):  
Breast Density ◽  
Quantitative Assessment ◽  
Ultrasound Tomography

scholarly journals Whole Breast Sound Speed Measurement from US Tomography Correlates Strongly with Volumetric Breast Density from Mammography

2020 ◽  
Vol 2 (5) ◽  
pp. 443-451
Author(s):  
Mark Sak ◽  
Peter Littrup ◽  
Rachel Brem ◽  
Neb Duric
Keyword(s):  
Breast Density ◽  
Sound Speed ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Mammographic Breast Density ◽  
Data Sets ◽  
Imaging Data ◽  
Institutional Review ◽  
Dense Tissue ◽  
Screening Mammograms

Abstract Objective To assess the feasibility of using tissue sound speed as a quantitative marker of breast density. Methods This study was carried out under an Institutional Review Board–approved protocol (written consent required). Imaging data were selected retrospectively based on the availability of US tomography (UST) exams, screening mammograms with volumetric breast density data, patient age of 18 to 80 years, and weight less than 300 lbs. Sound speed images from the UST exams were used to measure the volume of dense tissue, the volume averaged sound speed (VASS), and the percent of high sound speed tissue (PHSST). The mammographic breast density and volume of dense tissue were estimated with three-dimensional (3D) software. Differences in volumes were assessed with paired t-tests. Spearman correlation coefficients were calculated to determine the strength of the correlations between the mammographic and UST assessments of breast density. Results A total of 100 UST and 3D mammographic data sets met the selection criteria. The resulting measurements showed that UST measured a more than 2-fold larger volume of dense tissue compared to mammography. The differences were statistically significant (P < 0.001). A strong correlation of rS = 0.85 (95% CI: 0.79–0.90) between 3D mammographic breast density (BD) and the VASS was noted. This correlation is significantly stronger than those reported in previous two-dimensional studies (rS = 0.85 vs rS = 0.71). A similar correlation was found for PHSST and mammographic BD with rS = 0.86 (95% CI: 0.80–0.90). Conclusion The strong correlations between UST parameters and 3D mammographic BD suggest that breast sound speed should be further studied as a potential new marker for inclusion in clinical risk models.

Imaging of Sound Speed Using Reflection Ultrasound Tomography

2012 ◽  
Vol 31 (9) ◽  
pp. 1389-1404 ◽  
Author(s):  
Jakob Nebeker ◽  
Thomas R. Nelson
Keyword(s):  
Sound Speed ◽  
Ultrasound Tomography

scholarly journals Ultrasound Tomography Evaluation of Breast Density

2017 ◽  
Vol 52 (6) ◽  
pp. 343-348 ◽  
Author(s):  
Elizabeth A.M. OʼFlynn ◽  
Jeremie Fromageau ◽  
Araminta E. Ledger ◽  
Alessandro Messa ◽  
Ashley DʼAquino ◽  
...  
Keyword(s):  
Breast Density ◽  
Ultrasound Tomography

scholarly journals Comparison of sound speed measurements on two different ultrasound tomography devices

2014 ◽  
Author(s):  
Mark Sak ◽  
Neb Duric ◽  
Peter Littrup ◽  
Lisa Bey-Knight ◽  
Mark Sherman ◽  
...  
Keyword(s):  
Sound Speed ◽  
Ultrasound Tomography

Volumetric breast density evaluation from ultrasound tomography images

2008 ◽  
Vol 35 (9) ◽  
pp. 3988-3997 ◽  
Author(s):  
Carri K. Glide-Hurst ◽  
Neb Duric ◽  
Peter Littrup
Keyword(s):  
Breast Density ◽  
Ultrasound Tomography ◽  
Density Evaluation

scholarly journals Sound speed estimation using wave-based ultrasound tomography: theory and GPU implementation

2010 ◽  
Author(s):  
O. Roy ◽  
I. Jovanović ◽  
A. Hormati ◽  
R. Parhizkar ◽  
M. Vetterli
Keyword(s):  
Sound Speed ◽  
Speed Estimation ◽  
Ultrasound Tomography ◽  
Gpu Implementation

Novel approach to evaluating breast density utilizing ultrasound tomography

2007 ◽  
Vol 34 (2) ◽  
pp. 744-753 ◽  
Author(s):  
Carri Glide ◽  
Nebojsa Duric ◽  
Peter Littrup
Keyword(s):  
Breast Density ◽  
Ultrasound Tomography ◽  
Novel Approach
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