scholarly journals Comparison of sound speed measurements on two different ultrasound tomography devices

2014 ◽  
Author(s):  
Mark Sak ◽  
Neb Duric ◽  
Peter Littrup ◽  
Lisa Bey-Knight ◽  
Mark Sherman ◽  
...  
Keyword(s):  
Sound Speed ◽  
Ultrasound Tomography

scholarly journals Using Whole Breast Ultrasound Tomography to Improve Breast Cancer Risk Assessment: A Novel Risk Factor Based on the Quantitative Tissue Property of Sound Speed

2020 ◽  
Vol 9 (2) ◽  
pp. 367 ◽  
Author(s):  
Neb Duric ◽  
Mark Sak ◽  
Shaoqi Fan ◽  
Ruth M. Pfeiffer ◽  
Peter J. Littrup ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sound Speed ◽  
Menopausal Status ◽  
Surrogate Marker ◽  
Breast Ultrasound ◽  
Ultrasound Tomography ◽  
Breast Cancer Risk Assessment

Mammographic percent density (MPD) is an independent risk factor for developing breast cancer, but its inclusion in clinical risk models provides only modest improvements in individualized risk prediction, and MPD is not typically assessed in younger women because of ionizing radiation concerns. Previous studies have shown that tissue sound speed, derived from whole breast ultrasound tomography (UST), a non-ionizing modality, is a potential surrogate marker of breast density, but prior to this study, sound speed has not been directly linked to breast cancer risk. To that end, we explored the relation of sound speed and MPD with breast cancer risk in a case-control study, including 61 cases with recent breast cancer diagnoses and a comparison group of 165 women, frequency matched to cases on age, race, and menopausal status, and with a recent negative mammogram and no personal history of breast cancer. Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the relation of quartiles of MPD and sound speed with breast cancer risk adjusted for matching factors. Elevated MPD was associated with increased breast cancer risk, although the trend did not reach statistical significance (OR per quartile = 1.27, 95% CI: 0.95, 1.70; ptrend = 0.10). In contrast, elevated sound speed was significantly associated with breast cancer risk in a dose–response fashion (OR per quartile = 1.83, 95% CI: 1.32, 2.54; ptrend = 0.0003). The OR trend for sound speed was statistically significantly different from that observed for MPD (p = 0.005). These findings suggest that whole breast sound speed may be more strongly associated with breast cancer risk than MPD and offer future opportunities for refining the magnitude and precision of risk associations in larger, population-based studies, including women younger than usual screening ages.

Imaging of Sound Speed Using Reflection Ultrasound Tomography

2012 ◽  
Vol 31 (9) ◽  
pp. 1389-1404 ◽  
Author(s):  
Jakob Nebeker ◽  
Thomas R. Nelson
Keyword(s):  
Sound Speed ◽  
Ultrasound Tomography

scholarly journals Sound speed estimation using wave-based ultrasound tomography: theory and GPU implementation

2010 ◽  
Author(s):  
O. Roy ◽  
I. Jovanović ◽  
A. Hormati ◽  
R. Parhizkar ◽  
M. Vetterli
Keyword(s):  
Sound Speed ◽  
Speed Estimation ◽  
Ultrasound Tomography ◽  
Gpu Implementation

scholarly journals Determinants of the reliability of ultrasound tomography sound speed estimates as a surrogate for volumetric breast density

2015 ◽  
Vol 42 (10) ◽  
pp. 5671-5678 ◽  
Author(s):  
Zeina G. Khodr ◽  
Mark A. Sak ◽  
Ruth M. Pfeiffer ◽  
Nebojsa Duric ◽  
Peter Littrup ◽  
...  
Keyword(s):  
Breast Density ◽  
Sound Speed ◽  
Ultrasound Tomography

Ultrasound tomography of materials with high sound speed contrast

2017 ◽  
Vol 142 (4) ◽  
pp. 2537-2537
Author(s):  
Timothe Falardeau ◽  
Pierre Belanger
Keyword(s):  
Sound Speed ◽  
Ultrasound Tomography ◽  
High Sound

scholarly journals Multicenter Study of Whole Breast Stiffness Imaging by Ultrasound Tomography (SoftVue) for Characterization of Breast Tissues and Masses

2021 ◽  
Vol 10 (23) ◽  
pp. 5528
Author(s):  
Peter J. Littrup ◽  
Nebojsa Duric ◽  
Mark Sak ◽  
Cuiping Li ◽  
Olivier Roy ◽  
...  
Keyword(s):  
Sound Speed ◽  
Treatment Monitoring ◽  
Data Sets ◽  
Breast Volume ◽  
Ultrasound Tomography ◽  
Multicenter Cohort Study ◽  
Dense Breasts ◽  
Multicenter Cohort ◽  
Breast Tissues

We evaluated whole breast stiffness imaging by SoftVue ultrasound tomography (UST), extracted from the bulk modulus, to volumetrically map differences in breast tissues and masses. A total 206 women with either palpable or mammographically/sonographically visible masses underwent UST scanning prior to biopsy as part of a prospective, HIPAA-compliant multicenter cohort study. The volumetric data sets comprised 298 masses (78 cancers, 105 fibroadenomas, 91 cysts and 24 other benign) in 239 breasts. All breast tissues were segmented into six categories, using sound speed to separate fat from fibroglandular tissues, and then subgrouped by stiffness into soft, intermediate and hard components. Ninety percent of women had mammographically dense breasts but only 11.2% of their total breast volume showed hard components while 69% of fibroglandular tissues were softer. All smaller masses (<1.5 cm) showed a greater percentage of hard components than their corresponding larger masses (p < 0.001). Cancers had significantly greater mean stiffness indices and lower mean homogeneity of stiffness than benign masses (p < 0.05). SoftVue stiffness imaging demonstrated small stiff masses, mainly due to cancers, amongst predominantly soft breast tissues. Quantitative stiffness mapping of the whole breast and underlying masses may have implications for screening of women with dense breasts, cancer risk evaluations, chemoprevention and treatment monitoring.

scholarly journals The Fat-glandular Interface and Breast Tumor Locations: Appearances on Ultrasound Tomography Are Supported by Quantitative Peritumoral Analyses

2021 ◽  
Author(s):  
Peter J Littrup ◽  
Nebojsa Duric ◽  
Mark Sak ◽  
Cuiping Li ◽  
Olivier Roy ◽  
...  
Keyword(s):  
Sound Speed ◽  
Tumor Location ◽  
Breast Cancers ◽  
Ultrasound Tomography ◽  
Breast Masses ◽  
Fibroglandular Tissue ◽  
Institutional Review ◽  
Chi Squared ◽  
Malignant Breast ◽  
Dense Tissue

Abstract Objective To analyze the preferred tissue locations of common breast masses in relation to anatomic quadrants and the fat-glandular interface (FGI) using ultrasound tomography (UST). Methods Ultrasound tomography scanning was performed in 206 consecutive women with 298 mammographically and/or sonographically visible, benign and malignant breast masses following written informed consent to participate in an 8-site multicenter, Institutional Review Board-approved cohort study. Mass locations were categorized by their anatomic breast quadrant and the FGI, which was defined by UST as the high-contrast circumferential junction of fat and fibroglandular tissue on coronal sound speed imaging. Quantitative UST mass comparisons were done for each tumor and peritumoral region using mean sound speed and percentage of fibroglandular tissue. Chi-squared and analysis of variance tests were used to assess differences. Results Cancers were noted at the FGI in 95% (74/78) compared to 51% (98/194) of fibroadenomas and cysts combined (P &lt; 0.001). No intra-quadrant differences between cancer and benign masses were noted for tumor location by anatomic quadrants (P = 0.66). Quantitative peritumoral sound speed properties showed that cancers were surrounded by lower mean sound speeds (1477 m/s) and percent fibroglandular tissue (47%), compared to fibroadenomas (1496 m/s; 65.3%) and cysts (1518 m/s; 84%) (P &lt; 0.001; P &lt; 0.001, respectively). Conclusion Breast cancers form adjacent to fat and UST localized the vast majority to the FGI, while cysts were most often completely surrounded by dense tissue. These observations were supported by quantitative peritumoral analyses of sound speed values for fat and fibroglandular tissue.

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