A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent

2017 ◽  
Author(s):  
Mohsen Erfanzadeh ◽  
Michael Luciano ◽  
Feifei Zhou ◽  
Christian Brückner ◽  
Quing Zhu
Keyword(s):  
Contrast Agent ◽  
Water Soluble ◽  
Photoacoustic Tomography ◽  
Porphyrin Derivative

scholarly journals In vivo photoacoustic tumor tomography using a quinoline-annulated porphyrin as NIR molecular contrast agent

2017 ◽  
Vol 15 (4) ◽  
pp. 972-983 ◽  
Author(s):  
Michael Luciano ◽  
Mohsen Erfanzadeh ◽  
Feifei Zhou ◽  
Hua Zhu ◽  
Tobias Bornhütter ◽  
...  
Keyword(s):  
Mouse Model ◽  
Contrast Agent ◽  
Water Soluble ◽  
Photoacoustic Tomography ◽  
High Efficacy ◽  
Optical Window ◽  
Molecular Contrast

The water-soluble quinoline-annulated porphyrin, when irradiated within the optical window of tissue, shows in a mouse model high efficacy as a NIR photoacoustic tomography contrast agent.

In situ ultra-fast heat deposition does not perturb the structure of serum albumin

2016 ◽  
Vol 15 (12) ◽  
pp. 1524-1535 ◽  
Author(s):  
Otávio A. Chaves ◽  
Catarina S. H. Jesus ◽  
Elsa S. Henriques ◽  
Rui M. M. Brito ◽  
Carlos Serpa
Keyword(s):  
Protein Structure ◽  
Serum Albumin ◽  
Contrast Agent ◽  
Heat Release ◽  
Light Absorption ◽  
Water Soluble ◽  
Photoacoustic Tomography ◽  
Heat Deposition ◽  
Water Soluble Porphyrin

A metallic water soluble porphyrin with potential to be used as a contrast agent in photoacoustic tomography is effectively carried by serum albumin and the in situ heat release following light absorption does not cause damage to the protein structure.

Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain

Nano Letters ◽  
2004 ◽  
Vol 4 (9) ◽  
pp. 1689-1692 ◽  
Author(s):  
Yiwen Wang ◽  
Xueyi Xie ◽  
Xueding Wang ◽  
Geng Ku ◽  
Kelly L. Gill ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Rat Brain ◽  
Photoacoustic Tomography

scholarly journals Gd3+-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics

2017 ◽  
Vol 2017 ◽  
pp. 1-19 ◽  
Author(s):  
Nasim Hashempour Alamdari ◽  
Mahmood Alaei-Beirami ◽  
Seyed Ataollah Sadat Shandiz ◽  
Hadi Hejazinia ◽  
Rahimeh Rasouli ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Relaxation Times ◽  
Cost Effective ◽  
Water Soluble ◽  
Brain Targeting ◽  
Tumor Growth Inhibition ◽  
Effective Agent ◽  
Water Soluble Polymer ◽  
Mr Relaxation

Designing a unique theranostic biocompatible, biodegradable, and cost-effective agent which is easy to be synthesized as a biohybrid material was the aim of this study. In this matter, asparagine attached to anionic linear globular dendrimer G2 (as a biocompatible, biodegradable, and cost-effective agent which is negatively charged nanosized and water soluble polymer that outweighs other traditionally used dendrimers) and finally contrast agent (Gd3+) was loaded (which made complexes) in synthesized asparagine-dendrimer. Observations revealed that, in addition to successful colon cancer and brain targeting, Gd3+-dendrimer-asparagine, the proposed theranostic agent, could increase T1 MR relaxation times, decrease T2 MR relaxation times significantly, and improve contrast of image as well as illustrating good cellular uptake based on florescent microscopy/flow cytometry and ICP-mass data. In addition to that, it increased tumor growth inhibition percentage (TGI%) significantly compared to FDA approved contrast agent, Magnevist. Totally, Gd3+-anionic linear globular dendrimer G2-asparagine could be introduced to the cancer imaging/therapy (theranostics) protocols after in vivo MR and fluorescent analysis and passing clinical trials. Hence, this nanotheranostic agent would be a promising candidate for brain drug delivery and imaging in the future.

Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent

Nano Letters ◽  
2007 ◽  
Vol 7 (12) ◽  
pp. 3798-3802 ◽  
Author(s):  
Xinmai Yang ◽  
Sara E. Skrabalak ◽  
Zhi-Yuan Li ◽  
Younan Xia ◽  
Lihong V. Wang
Keyword(s):  
Cerebral Cortex ◽  
Contrast Agent ◽  
Rat Cerebral Cortex ◽  
Photoacoustic Tomography ◽  
Optical Contrast ◽  
Optical Contrast Agent

Gold Nanoparticles as Contrast Agent for in Vivo Photoacoustic Tomography of Tumor

2008 ◽  
Author(s):  
Qizhi Zhang ◽  
Nobutaka Iwakuma ◽  
Matthew Delano ◽  
Parvesh Sharma ◽  
Changfeng Wu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Contrast Agent ◽  
Photoacoustic Tomography

Fenofibrate Solid Dispersion for Improving Oral Bioavailability: Preparation, and Characterization and in vivo Evaluation

2020 ◽  
Vol 13 (5) ◽  
pp. 5102-5109
Author(s):  
Venu Madhav K ◽  
Somnath De ◽  
Chandra Shekar Bonagiri ◽  
Sridhar Babu Gummadi
Keyword(s):  
Oral Bioavailability ◽  
Oral Delivery ◽  
Solid Dispersions ◽  
In Vitro Release ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
Scanning Calorimetry ◽  
In Vivo Evaluation

Fenofibrate (FN) is used in the treatment of hypercholesterolemia. It shows poor dissolution and poor oral bioavailability after oral administration due to high liphophilicity and low aqueous solubility. Hence, solid dispersions (SDs) of FN (FN-SDs) were develop that might enhance the dissolution and subsequently oral bioavailability. FN-SDs were prepared by solvent casting method using different carriers (PEG 4000, PEG 6000, β cyclodextrin and HP β cyclodextrin) in different proportions (0.25%, 0.5%, 0.75% and 1% w/v). FN-SDs were evaluated solubility, assay and in vitro release studies for the optimization of SD formulation. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) analysis was performed for crystalline and morphology analysis, respectively. Further, optimized FN-SD formulation evaluated for pharmacokinetic performance in Wistar rats, in vivo in comparison with FN suspension.  From the results, FN-SD3 and FN-SD6 have showed 102.9 ±1.3% and 105.5±3.1% drug release, respectively in 2 h. DSC and PXRD studies revealed that conversion of crystalline to amorphous nature of FN from FT-SD formulation. SEM studies revealed the change in the orientation of FN when incorporated in SDs. The oral bioavailability FN-SD3 and FN-SD6 formulations exhibited 2.5-folds and 3.1-folds improvement when compared to FN suspension as control. Overall, SD of FN could be considered as an alternative dosage form for the enhancement of oral delivery of poorly water-soluble FN.

Chemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic Hydroxamic Acids for Combination Chemotherapy of Lymphatic Leukemia

2018 ◽  
Vol 18 (4) ◽  
pp. 365-371 ◽  
Author(s):  
Denis V. Mishchenko ◽  
Margarita E. Neganova ◽  
Elena N. Klimanova ◽  
Tatyana E. Sashenkova ◽  
Sergey G. Klochkov ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Acute Toxicity ◽  
Histone Deacetylases ◽  
Hydroxamic Acids ◽  
Water Soluble ◽  
Male Rat ◽  
Hybrid Male ◽  
Cyclic Hydroxamic Acids

Background: Anti-tumor effect of hydroxamic acid derivatives is largely connected with its properties as efficient inhibitors of histone deacetylases, and other metalloenzymes involved in carcinogenesis. Objective: The work was aimed to (i) determine the anti-tumor and chemosensitizing activity of the novel racemic spirocyclic hydroxamic acids using experimental drug sensitive leukemia P388 of mice, and (ii) determine the structure-activity relationships as metal chelating and HDAC inhibitory agents. Method: Outbreed male rat of 200-220 g weights were used in biochemical experiments. In vivo experiments were performed using the BDF1 hybrid male mice of 22-24 g weight. Lipid peroxidation, Fe (II) -chelating activity, HDAC fluorescent activity, anti-tumor and anti-metastatic activity, acute toxicity techniques were used in this study. Results: Chemosensitizing properties of water soluble cyclic hydroxamic acids (CHA) are evaluated using in vitro activities and in vivo methods and found significant results. These compounds possess iron (II) chelating properties, and slightly inhibit lipid peroxidation. CHA prepared from triacetonamine (1a-e) are more effective Fe (II) ions cheaters, as compared to CHA prepared from 1- methylpiperidone (2a-e). The histone deacetylase (HDAC) inhibitory activity, lipophilicity and acute toxicity were influenced by the length amino acids (size) (Glycine < Alanine < Valine < Leucine < Phenylalanine). All compounds bearing spiro-N-methylpiperidine ring (2a-e) are non-toxic up to 1250 mg/kg dose, while compounds bearing spiro-tetramethylpiperidine ring (1a-e) exhibit moderate toxicity which increases with increasing lipophility, but not excite at 400 mg/kg. Conclusion: It was shown that the use of combination of non-toxic doses of cisplatin (cPt) or cyclophosphamide with CHA in most cases result in the appearance of a considerable anti-tumor effect of cytostatics. The highest chemosensitizing activity with respect to leukemia Р388 is demonstrated by the CHA derivatives of Valine 1c or 2c.

In Vivo MRI Visualization of Acute Myocardial Ischemia and Reperfusion in Ferrets by the Persistent Action of the Contrast Agent Gd(BME-DTTA)

Circulation ◽  
1995 ◽  
Vol 92 (12) ◽  
pp. 3549-3559 ◽  
Author(s):  
Tamás Simor ◽  
Wen-Jang Chu ◽  
Lynne Johnson ◽  
Andras Safranko ◽  
Mark Doyle ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Contrast Agent ◽  
Acute Myocardial Ischemia ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion
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