In situ ultra-fast heat deposition does not perturb the structure of serum albumin

2016 ◽  
Vol 15 (12) ◽  
pp. 1524-1535 ◽  
Author(s):  
Otávio A. Chaves ◽  
Catarina S. H. Jesus ◽  
Elsa S. Henriques ◽  
Rui M. M. Brito ◽  
Carlos Serpa
Keyword(s):  
Protein Structure ◽  
Serum Albumin ◽  
Contrast Agent ◽  
Heat Release ◽  
Light Absorption ◽  
Water Soluble ◽  
Photoacoustic Tomography ◽  
Heat Deposition ◽  
Water Soluble Porphyrin

A metallic water soluble porphyrin with potential to be used as a contrast agent in photoacoustic tomography is effectively carried by serum albumin and the in situ heat release following light absorption does not cause damage to the protein structure.

A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent

2017 ◽  
Author(s):  
Mohsen Erfanzadeh ◽  
Michael Luciano ◽  
Feifei Zhou ◽  
Christian Brückner ◽  
Quing Zhu
Keyword(s):  
Contrast Agent ◽  
Water Soluble ◽  
Photoacoustic Tomography ◽  
Porphyrin Derivative

scholarly journals In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies

2017 ◽  
Vol Volume 12 ◽  
pp. 4073-4084 ◽  
Author(s):  
Priyanka Singh ◽  
Yeon Ju Kim ◽  
Hina Singh ◽  
Sungeun Ahn ◽  
Verónica Castro-Aceituno ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Water Soluble ◽  
Ginsenoside Rh2 ◽  
Albumin Nanoparticles ◽  
In Situ Preparation

scholarly journals In vivo photoacoustic tumor tomography using a quinoline-annulated porphyrin as NIR molecular contrast agent

2017 ◽  
Vol 15 (4) ◽  
pp. 972-983 ◽  
Author(s):  
Michael Luciano ◽  
Mohsen Erfanzadeh ◽  
Feifei Zhou ◽  
Hua Zhu ◽  
Tobias Bornhütter ◽  
...  
Keyword(s):  
Mouse Model ◽  
Contrast Agent ◽  
Water Soluble ◽  
Photoacoustic Tomography ◽  
High Efficacy ◽  
Optical Window ◽  
Molecular Contrast

The water-soluble quinoline-annulated porphyrin, when irradiated within the optical window of tissue, shows in a mouse model high efficacy as a NIR photoacoustic tomography contrast agent.

Functional Poly(p-Xylylene)s via Chemical Reduction of Poly(p-Phenylene Vinylene)s

2019 ◽  
Author(s):  
Ain Uddin ◽  
Weifan Sang ◽  
Yong Gao ◽  
Kyle Plunkett
Keyword(s):  
Film Formation ◽  
Chemical Reduction ◽  
Water Soluble ◽  
Phenylene Vinylene ◽  
Polymer Modification ◽  
Polymer Backbone ◽  
Crosslinking Process ◽  
Conducting Membranes ◽  
In Situ Crosslinking

The synthesis of poly(p-xylylene)s (PPXs) with sidechains containing alkyl bromide functionality, and their post-polymer modification, is described. The PPXs were prepared by a diimide hydrogenation of poly(p-phenylene vinylene)s (PPVs) that were originally synthesized by a Gilch polymerization. The polymer backbone reduction was carried out with hydrazine hydrate in toluene at 80 °C to provide polymers with the sidechain-containing bromide functionality intact. To demonstrate post-polymer modification of the sidechains, the resulting PPX polymers were modified with trimethylamine to form tetraalkylammonium ion functionality and were evaluated as anion conducting membranes. While PPX homopolymers containing tetralkylammonium ions were completely water soluble and not able to form valuable films, PPX copolymers containing mixed tetraalkylammonium ions and hydrophobic chains were capable of film formation and alkaline stability. In addition, an in situ crosslinking process that used N,N,N',N'-tetramethyl-1,6-hexanediamine during the tetraalkylammonium formation of brominated PPX polymers was also evaluated and gave reasonable films with conductivities of ~10 mS-cm-1.

Functional Poly(p-Xylylene)s via Chemical Reduction of Poly(p-Phenylene Vinylene)s

2019 ◽  
Author(s):  
Ain Uddin ◽  
Weifan Sang ◽  
Yong Gao ◽  
Kyle Plunkett
Keyword(s):  
Film Formation ◽  
Chemical Reduction ◽  
Water Soluble ◽  
Phenylene Vinylene ◽  
Polymer Modification ◽  
Polymer Backbone ◽  
Crosslinking Process ◽  
Conducting Membranes ◽  
In Situ Crosslinking

The synthesis of poly(p-xylylene)s (PPXs) with sidechains containing alkyl bromide functionality, and their post-polymer modification, is described. The PPXs were prepared by a diimide hydrogenation of poly(p-phenylene vinylene)s (PPVs) that were originally synthesized by a Gilch polymerization. The polymer backbone reduction was carried out with hydrazine hydrate in toluene at 80 °C to provide polymers with the sidechain-containing bromide functionality intact. To demonstrate post-polymer modification of the sidechains, the resulting PPX polymers were modified with trimethylamine to form tetraalkylammonium ion functionality and were evaluated as anion conducting membranes. While PPX homopolymers containing tetralkylammonium ions were completely water soluble and not able to form valuable films, PPX copolymers containing mixed tetraalkylammonium ions and hydrophobic chains were capable of film formation and alkaline stability. In addition, an in situ crosslinking process that used N,N,N',N'-tetramethyl-1,6-hexanediamine during the tetraalkylammonium formation of brominated PPX polymers was also evaluated and gave reasonable films with conductivities of ~10 mS-cm-1.

scholarly journals Development of In Situ Gelling Meloxicam-Human Serum Albumin Nanoparticle Formulation for Nose-to-Brain Application

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 646
Author(s):  
Gábor Katona ◽  
Bence Sipos ◽  
Mária Budai-Szűcs ◽  
György Tibor Balogh ◽  
Szilvia Veszelka ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Nasal Mucosa ◽  
Drug Absorption ◽  
Cell Damage ◽  
Lipid Fraction ◽  
Poloxamer 407 ◽  
Nasal Drug Delivery

The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407), which can be administered in liquid state into the nostril, and to increase the resistance of the formulation against mucociliary clearance by sol-gel transition on the nasal mucosa, as well as to improve drug absorption. Nanoparticle characterization showed that formulations containing 12–15% w/w P407 met the requirements of intranasal administration. The Z-average (in the range of 180–304 nm), the narrow polydispersity index (PdI, from 0.193 to 0.328), the zeta potential (between −9.4 and −7.0 mV) and the hypotonic osmolality (200–278 mOsmol/L) of MEL-HSA nanoparticles predict enhanced drug absorption through the nasal mucosa. Based on the rheological, muco-adhesion, drug release and permeability studies, the 14% w/w P407 containing formulation (MEL-HSA-P14%) was considered as the optimized formulation, which allows enhanced permeability of MEL through blood–brain barrier-specific lipid fraction. Cell line studies showed no cell damage after 1-h treatment with MEL-HSA-P14% on RPMI 2650 human endothelial cells’ moreover, enhanced permeation (four-fold) of MEL from MEL-HSA-P14% was observed in comparison to pure MEL. Overall, MEL-HSA-P14% can be promising for overcoming the challenges of nasal drug delivery.

scholarly journals A thin, deformable, high-performance supercapacitor implant that can be biodegraded and bioabsorbed within an animal body

2021 ◽  
Vol 7 (2) ◽  
pp. eabe3097
Author(s):  
Hongwei Sheng ◽  
Jingjing Zhou ◽  
Bo Li ◽  
Yuhang He ◽  
Xuetao Zhang ◽  
...  
Keyword(s):  
High Performance ◽  
Electronic Devices ◽  
Form Factors ◽  
Time Frame ◽  
Water Soluble ◽  
Two Dimensional ◽  
Medical Electronics ◽  
Thin Structure ◽  
Shed Light

It has been an outstanding challenge to achieve implantable energy modules that are mechanically soft (compatible with soft organs and tissues), have compact form factors, and are biodegradable (present for a desired time frame to power biodegradable, implantable medical electronics). Here, we present a fully biodegradable and bioabsorbable high-performance supercapacitor implant, which is lightweight and has a thin structure, mechanical flexibility, tunable degradation duration, and biocompatibility. The supercapacitor with a high areal capacitance (112.5 mF cm−2 at 1 mA cm−2) and energy density (15.64 μWh cm−2) uses two-dimensional, amorphous molybdenum oxide (MoOx) flakes as electrodes, which are grown in situ on water-soluble Mo foil using a green electrochemical strategy. Biodegradation behaviors and biocompatibility of the associated materials and the supercapacitor implant are systematically studied. Demonstrations of a supercapacitor implant that powers several electronic devices and that is completely degraded after implantation and absorbed in rat body shed light on its potential uses.

Synthesis and short DNA in situ loading and delivery of 4 nm-aperture flexible organic frameworks

2021 ◽  
Author(s):  
Ze-Kun Wang ◽  
Jia-Le Lin ◽  
Yun-Chang Zhang ◽  
Chen-Wu Yang ◽  
Ya-Kun Zhao ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Water Soluble

Water-soluble hydrazone-connected 3D flexible organic frameworks have been revealed to in situ load and deliver short DNA into normal and cancer cells.

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