Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography

2015 ◽  
Author(s):  
Jui-Kai Wang ◽  
Patrick A. Sibony ◽  
Randy H. Kardon ◽  
Mark J. Kupersmith ◽  
Mona K. Garvin
Keyword(s):  
Optical Coherence Tomography ◽  
Shape Analysis ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Membrane Shape

scholarly journals Effect of Hydroxychloroquine on the Retinal Layers: A Quantitative Evaluation with Spectral-Domain Optical Coherence Tomography

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Hasim Uslu ◽  
Bulent Gurler ◽  
Aydin Yildirim ◽  
Mehmet Gurkan Tatar ◽  
Feride Aylin Kantarcı ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Outer Segment ◽  
Spectral Domain ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Control Subjects ◽  
Membrane Complex ◽  
Sd Oct

Purpose.To evaluate the effect of hydroxychloroquine on retinal pigment epithelium- (RPE-) Bruch’s membrane complex, photoreceptor outer segment, and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses using spectral-domain optical coherence tomography (SD-OCT).Methods.In this prospective case-control study, 51 eyes of 51 hydroxychloroquine patients and 30 eyes of 30 healthy subjects were included. High-quality images were obtained using a Cirrus HD-OCT with 5-line raster mode; the photoreceptor inner segment (IS) and outer segment (OS), sum of the segments (IS + OS), and RPE-Bruch’s membrane complex were analyzed.Results.The thicknesses of the IS + OS and OS layers were significantly lower in the hydroxychloroquine subjects compared to the control subjects (P<0.05). RPE-Bruch’s membrane complex thicknesses were significantly higher in the hydroxychloroquine subjects than for those of the control subjects (P<0.05). The minimum and temporal-inferior macular GCIPL thicknesses were significantly different between the patients with hydroxychloroquine use and the control subjects (P=0.04andP=0.03, resp.).Conclusions.The foveal photoreceptor OS thinning, loss of GCIPL, and RPE-Bruch’s membrane thickening were detected in patients with hydroxychloroquine therapy. This quantitative approach using SD-OCT images may have important implications to use as an early indicator of retinal toxicity without any visible signs of hydroxychloroquine retinopathy.

Sign in / Sign up

Export Citation Format

Share Document