scholarly journals Intra- and interobserver reproducibility of Bruch's membrane opening minimum rim width measurements with spectral domain optical coherence tomography

2017 ◽  
Vol 95 (7) ◽  
pp. e548-e555 ◽  
Author(s):  
Alexandre S. C. Reis ◽  
Camila e S. Zangalli ◽  
Ricardo Y. Abe ◽  
André L. Silva ◽  
Jayme R. Vianna ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Interobserver Reproducibility ◽  
Bruch’S Membrane Opening ◽  
Width Measurements

scholarly journals Effect of Hydroxychloroquine on the Retinal Layers: A Quantitative Evaluation with Spectral-Domain Optical Coherence Tomography

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Hasim Uslu ◽  
Bulent Gurler ◽  
Aydin Yildirim ◽  
Mehmet Gurkan Tatar ◽  
Feride Aylin Kantarcı ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Outer Segment ◽  
Spectral Domain ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Control Subjects ◽  
Membrane Complex ◽  
Sd Oct

Purpose.To evaluate the effect of hydroxychloroquine on retinal pigment epithelium- (RPE-) Bruch’s membrane complex, photoreceptor outer segment, and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses using spectral-domain optical coherence tomography (SD-OCT).Methods.In this prospective case-control study, 51 eyes of 51 hydroxychloroquine patients and 30 eyes of 30 healthy subjects were included. High-quality images were obtained using a Cirrus HD-OCT with 5-line raster mode; the photoreceptor inner segment (IS) and outer segment (OS), sum of the segments (IS + OS), and RPE-Bruch’s membrane complex were analyzed.Results.The thicknesses of the IS + OS and OS layers were significantly lower in the hydroxychloroquine subjects compared to the control subjects (P<0.05). RPE-Bruch’s membrane complex thicknesses were significantly higher in the hydroxychloroquine subjects than for those of the control subjects (P<0.05). The minimum and temporal-inferior macular GCIPL thicknesses were significantly different between the patients with hydroxychloroquine use and the control subjects (P=0.04andP=0.03, resp.).Conclusions.The foveal photoreceptor OS thinning, loss of GCIPL, and RPE-Bruch’s membrane thickening were detected in patients with hydroxychloroquine therapy. This quantitative approach using SD-OCT images may have important implications to use as an early indicator of retinal toxicity without any visible signs of hydroxychloroquine retinopathy.

Influence of Bruch's Membrane Opening Area in Diagnosing Glaucoma With Neuroretinal Parameters From Optical Coherence Tomography

2019 ◽  
Vol 208 ◽  
pp. 94-102 ◽  
Author(s):  
Lucas A. Torres ◽  
Glen P. Sharpe ◽  
Donna M. Hutchison ◽  
Camila S. Zangalli ◽  
Reinhard O. Burk ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Bruch’S Membrane Opening

scholarly journals Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch’s membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis

2017 ◽  
Vol 102 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Sami W Kabbara ◽  
Linda M Zangwill ◽  
Rusdeep Mundae ◽  
Naama Hammel ◽  
Christopher Bowd ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Characteristic Curve ◽  
Optical Coherence ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Significant Difference ◽  
Bruch’S Membrane Opening ◽  
Scan Pattern ◽  
Healthy Eyes ◽  
Sd Oct

AimTo compare the cube and radial scan patterns of the spectral domain optical coherence tomography (SD-OCT) for quantifying the Bruch’s membrane opening minimum rim width (BMO-MRW).MethodsSixty healthy eyes and 189 glaucomatous eyes were included. The optic nerve head cube and radial pattern scans were acquired using Spectralis SD-OCT. BMO-MRWs were automatically delineated using the San Diego Automated Layer Segmentation Algorithm. The BMO-MRW diagnostic accuracy for glaucoma detection and rates of change derived from the two scan patterns were compared.ResultsThere was a significant difference between the baseline global BMO-MRW measurements of cube and radial scans for healthy (301.9±57.8 µm and 334.7±61.8 µm, respectively, p<0.003) and glaucoma eyes (181.2±63.0 µm and 210.2±67.2 µm, respectively, p<0.001). The area under the receiver operating characteristic curve for differentiating between healthy and glaucoma eyes was 0.90 for both the radial scan-based and cube scan-based BMO-MRW. No significant difference in the rate of BMO-MRW change (mean follow-up years) by scan pattern was found among both healthy (cube: −1.47 µm/year, radial: −1.53 µm/year; p=0.48) (1.6 years) and glaucoma eyes (cube: −2.37 µm/year, radial: −2.28 µm/year; p=0.45) (2.6 years).ConclusionAlthough the cube scan-based BMO-MRW was significantly smaller than the radial scan-based BMO-MRW, we found no significant difference between the two scan patterns for detecting glaucoma, identifying BMO location and measuring the rate of BMO-MRW change. These results suggest that although BMO-MRW estimates are not interchangeable, both scan patterns can be used for monitoring BMO-MRW changes over time.

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