Microfluidic device integrated with FBG in Co2+-doped fiber to measure flow rate with nL/s sensitivity

2014 ◽  
Author(s):  
Zhengyong Liu ◽  
A. Ping Zhang ◽  
Hwa-Yaw Tam
Keyword(s):  
Microfluidic Device ◽  
Flow Rate ◽  
Measure Flow Rate

Continuous separation of particles using a microfluidic device equipped with flow rate control valves

2006 ◽  
Vol 1127 (1-2) ◽  
pp. 214-220 ◽  
Author(s):  
Yuushi Sai ◽  
Masumi Yamada ◽  
Masahiro Yasuda ◽  
Minoru Seki
Keyword(s):  
Microfluidic Device ◽  
Flow Rate ◽  
Rate Control ◽  
Continuous Separation ◽  
Control Valves ◽  
Flow Rate Control

LTCC 3D FLOW FOCALIZATION DEVICE FOR LIQUID-LIQUID PARTIAL SOLVENT EXTRACTION

2016 ◽  
Vol 2016 (CICMT) ◽  
pp. 000111-000117
Author(s):  
Houari Cobas Gomez ◽  
Jéssica Gonçalves da Silva ◽  
Jocasta Mileski Machado ◽  
Bianca Oliveira Agio ◽  
Francisco Jorge Soares de Oliveira ◽  
...  
Keyword(s):  
Solvent Extraction ◽  
Aqueous Phase ◽  
Microfluidic Device ◽  
Flow Rate ◽  
Extraction Efficiency ◽  
Channel Length ◽  
Main Channel ◽  
Process Variables ◽  
3D Flow ◽  
Acetone Concentration

Abstract The present work shows a ceramics microfluidic device for partial solvent extraction scheme. The technology used for device fabrication was Low Temperature Cofired Ceramics (LTCC) which allows us for complex and chemical resistant 3D microfluidic devices. The proposed system aims to partially extract the solvent present in a mixture containing aqueous and organic phases. This scheme uses a 3D flow focalization in order to improve the solvent diffusion into the external aqueous phase. The device is composed by three different parts, the input channels distribution, the main channel and the output channels distribution. The designed input channels distribution ensures a centered 3D focalized solvent stream along the main channel. The focalized solvent mixes with the surrounding water thanks to diffusion. Projected output channels take the central fluid out separately from the surrounding. Thus the device has two different outputs, one for the focalized fluid and another one for the waste fluid, which is the aqueous phase plus solvent. For a device concept proof, acetone and water were used as organic and aqueous phases, respectively. COMSOL Multiphysics was used for device microfluidics and chemical transport simulation. The extraction efficiency was the variable used as indicator for device performance validation. The flow rate ratio between phases, total flow rate, main channel length and focalized stream channel output hydraulic diameter (ODH) were used as process variables for simulation purposes. A factorial experimental planning was used in order to analyze the extraction efficiency taking into account process variables effects. From simulation results it was determined main channel length and ODH as the variables with stronger effect on extraction efficiency. Obtained simulated efficiencies were as high as 80.6%. Considering previous results observations a microfluidic device was fabricated with a main channel length of 21,4 mm and ODH of 214,63 μm. Gas chromatography was used to measured acetone concentration in outputs samples and from here the extraction efficiency. Experimental results were in agreement with simulation, returning extraction efficiencies in the order of 80.8% ± 2.2%.

LTCC 3D MICROMIXERS FOR NON-MISCIBLE FLUIDS MICROEMULSION GENERATION

2016 ◽  
Vol 2016 (CICMT) ◽  
pp. 000096-000102
Author(s):  
Houari Cobas Gomez ◽  
Bianca Oliveira Agio ◽  
Jéssica Gonçalves da Silva ◽  
Natalia Neto Pereira Cerize ◽  
Adriano Marim de Oliveira ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Flow Rate ◽  
Device Fabrication ◽  
Chaotic Advection ◽  
Drop Diameter ◽  
Production Volume ◽  
Total Flow ◽  
Total Flow Rate ◽  
Miscible Fluids ◽  
Working Region

Abstract The present work shows a ceramics microfluidic device for non-miscible fluids microemulsion generation using 3D serpentine micromixers. The technology used for device fabrication was Low Temperature Cofired Ceramics (LTCC) which allows us for complex, high temperature and pressure resistant 3D microfluidic devices. The proposed device aims to obtain microemulsion with controlled drop size, low dispersion index and high production volumes using Top-Down approach. Previous simulation work had showed 3D serpentine as one of the best structures for rapid mixing due the chaotic advection generated on every 90 deg direction change. This effect, when mixing two fluids as oil and water leads to streamlines pinching-off making possible drop generation. We have used this effect on our device. For the experimental section, it was fabricated a 3D serpentine mixer microfluidic device with working region suitable for variable total flow rate. For certain value of total flow rate, the microemulsion showed higher drop diameter and polydispersity values. In this region, no control could be done in order to obtain the same drop value with the same process parameters. Inside the working region drop diameter values repeatability was obtained. In this region our experimental results had showed a relation between drop diameter and total flow rate. As a total flow rate increase the drop diameter decrease due to a stronger chaotic advection effect. In the other hand, the polydispersity index also decreases. Microemulsions with average size lower than few micrometer or submicron were obtained. When compared with other reported devices, our device presented a production volume in the range of tens of ml/s for the same output microemulsion size.

scholarly journals Learning The Fluid/Flow Properties Using Microfluidics

2019 ◽  
Vol 215 ◽  
pp. 10002
Author(s):  
Pooria Hadikhani ◽  
Navid Borhani ◽  
S. Mohammad H. Hashemi ◽  
Demetri Psaltis
Keyword(s):  
Neural Networks ◽  
Fluid Flow ◽  
Microfluidic Device ◽  
Flow Rate ◽  
Deep Neural Networks ◽  
Good Accuracy ◽  
Flow Properties ◽  
Flow Rates

Deep neural networks (DNN) are employed to measure the flow rate and the concentration of the liquid using the images of the droplets in a microfluidic device. The trained networks are able to measure flow rates and concentrations with good accuracy.

Comparison of Geometries for Diffusion-Based Extraction of Dimethyl Sulphoxide From a Cell Suspension

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
Katie Fleming Glass ◽  
Clara Mata ◽  
Ellen K. Longmire ◽  
Allison Hubel
Keyword(s):  
Microfluidic Device ◽  
Flow Rate ◽  
Channel Length ◽  
Dimethyl Sulphoxide ◽  
Hematopoietic Stem ◽  
Cryoprotective Agents ◽  
Multi Stage ◽  
Flow Geometry ◽  
A Cell ◽  
Flow Configurations

Microfluidics can be used in a variety of medical applications. In this study, a microfluidic device is being developed to remove cryoprotective agents from cells post thaw (1–150ml). Hematopoietic stem cells are typically cryopreserved with Dimethyl sulphoxide (DMSO), which is toxic upon infusion. Conventional methods of removing DMSO results in cells losses of 25–30%. The overall objective of this study is to characterize the influence of flow geometry on extraction of DMSO from a cell stream. For all the flow geometries analyzed, flow rate fraction, Peclet Number, and channel geometry had the greatest influence on extraction of DMSO from the cell stream. The range of flow rate fractions that can achieve the desired removal ranges between 0.10 and 0.30. Similarly, the range of Peclet numbers is 250–2500. Distinct differences in channel length could be observed between the different flow configurations studied. The flow rates and channel geometries studied suggest that clinical volumes of cell suspensions (1–100ml) can be processed using a multi-stage microfluidic device in short periods of time (<1hr).

scholarly journals Synthesis of Copper Nanoparticles Using Glass Microfluidic Device

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 1110
Author(s):  
Yiyang Liang ◽  
Yoko Shinozaki ◽  
Hiromasa Yagyu
Keyword(s):  
Particle Size ◽  
Ascorbic Acid ◽  
Microfluidic Device ◽  
Copper Nanoparticles ◽  
Flow Rate ◽  
Control Method ◽  
Size Control ◽  
Metallic Materials ◽  
First Time ◽  
Citrate Reduction

In a synthesis of gold nanoparticles on a microfluidic device by citrate reduction, a particle size control by changing a flow rate was reported. To apply this simple control method to the synthesis of other metallic materials, we propose the synthesis of copper nanoparticles (CuNPs) in ethylene glycol by the microfluidic device using ascorbic acid as both antioxidant and reducing agent. The experimental results found for the first time that the effect of the flow rate of agents on particle size of the synthesized CuNPs in the device.

scholarly journals A novel microfluidic chip-based sperm-sorting device constructed using design of experiment method

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chalinee Phiphattanaphiphop ◽  
Komgrit Leksakul ◽  
Rungrueang Phatthanakun ◽  
Trisadee Khamlor
Keyword(s):  
Microfluidic Device ◽  
Flow Rate ◽  
Microfluidic Chip ◽  
Design Of Experiment ◽  
Fluid Viscosity ◽  
Inlet Flow ◽  
Factors Affecting ◽  
Inlet Flow Rate ◽  
Sperm Sorting ◽  
Bull Sperm

Abstract Microfluidics is proposed as a technique for efficient sperm sorting, to achieve the ultimate goal of resolving infertility problems in livestock industry. Our study aimed to design a microfluidic sperm-sorting device (SSD) through a high-efficacy and cost- and time-effective fabrication process, by using COMSOL Multiphysics simulation and modeling software, and the design of experiment (DOE) method. The eight factors affecting SSD performance were established. The simulation was then run, and statistically significant factors were analyzed. Minitab16 was used to optimize the design modulus factor. By setting the statistical significance at p < 0.05, the factors affecting experimental structure were analyzed. At a desirability of 97.99, the optimal parameters for the microfluidic chip were: angle between sperm and medium inlet chambers (A = 43°), sperm inlet flow rate (B = 0.24 µL min−1), medium inlet flow rate (C = 0.34 µL min−1), and inlet and outlet chamber lengths (D = 5000 µm). These optima were then applied to microfluidics device construction. The device was produced using soft lithographic microfabrication techniques and tested on Holstein–Friesian bull sperm. The highest bull sperm-sorting performance for this microfluidic device prototype was 96%. The error between the simulation and the actual microfluidic device was 2.72%. Fluid viscosity ranges analysis-based simulations revealed acceptable fluid viscosity tolerances for the SSD. The simulation results revealed that the acceptable tolerance range for fluid viscosity was 0.00001–0.003 kg m−1 s−1. This optimally designed microfluidic chip-based SSD may be integrated into sperm x/y separation micro devices.

Experimental Study of Various Porosity of Fractal Flow Conditioner for Orifice Plate Flowmeters

2014 ◽  
Vol 699 ◽  
pp. 915-920 ◽  
Author(s):  
Bukhari Manshoor ◽  
Mohd Fahmi Othman ◽  
Izzuddin Zaman ◽  
Zamani Ngali ◽  
Amir Khalid
Keyword(s):  
Experimental Study ◽  
Pressure Drop ◽  
Mass Flow Rate ◽  
Flow Rate ◽  
Experimental Work ◽  
Discharge Coefficient ◽  
Orifice Plate ◽  
Rate Data ◽  
Plant Industry ◽  
Measure Flow Rate

The plant industry is required to measure flow rate more accurately to meet plant operation and cost accounting objectives. The opposing concern of improving flow meter accuracy is resolved by using flow conditioners. The distance of implementation of flow conditioner upstream of the orifice plate flowmeter is also need to be addressed. Hence, in present study, an analysis of the porosity of fractal flow conditioner towards orifice plate flowmeter’s accuracy and the best distance of fractal flow conditioner upstream of the orifice plate flowmeter was determined. In an experimental work, a different porosity of the fractal flow conditioners were installed with different distance upstream of the orifice plate in conjunction with the different disturbances to assess the effects of these devices on the measurement of the mass flow rate. Data gained for all the plates showed that there is increment of pressure drop and change in discharge coefficient of the orifice with lower β value of fractal flow conditioner. Good comparisons with the previous experimental work demonstrate the fractal flow conditioner can preserve the accuracy of metering up to the level required in the standards.

scholarly journals Nozzle-Shaped Electrode Configuration for Dielectrophoretic 3D-Focusing of Microparticles

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 585 ◽  
Author(s):  
Krishna ◽  
Alnaimat ◽  
Mathew
Keyword(s):  
Mathematical Model ◽  
Microfluidic Device ◽  
Flow Rate ◽  
Electric Potential ◽  
Performance Metrics ◽  
Volumetric Flow Rate ◽  
Electrode Configuration ◽  
Electrode Length ◽  
The Mathematical Model ◽  
Applied Electric Potential

: An experimentally validated mathematical model of a microfluidic device with nozzle-shaped electrode configuration for realizing dielectrophoresis based 3D-focusing is presented in the article. Two right-triangle shaped electrodes on the top and bottom surfaces make up the nozzle-shaped electrode configuration. The mathematical model consists of equations describing the motion of microparticles as well as profiles of electric potential, electric field, and fluid flow inside the microchannel. The influence of forces associated with inertia, gravity, drag, virtual mass, dielectrophoresis, and buoyancy are taken into account in the model. The performance of the microfluidic device is quantified in terms of horizontal and vertical focusing parameters. The influence of operating parameters, such as applied electric potential and volumetric flow rate, as well as geometric parameters, such as electrode dimensions and microchannel dimensions, are analyzed using the model. The performance of the microfluidic device enhances with an increase in applied electric potential and reduction in volumetric flow rate. Additionally, the performance of the microfluidic device improves with reduction in microchannel height and increase in microparticle radius while degrading with increase in reduction in electrode length and width. The model is of great benefit as it allows for generating working designs of the proposed microfluidic device with the desired performance metrics.

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