Label-free silicon photonic biosensors for use in clinical diagnostics

2013 ◽  
Author(s):  
Sahba Talebi Fard ◽  
Samantha M. Grist ◽  
Valentina Donzella ◽  
Shon A. Schmidt ◽  
Jonas Flueckiger ◽  
...  
Keyword(s):  
Clinical Diagnostics ◽  
Label Free ◽  
Free Silicon ◽  
Silicon Photonic ◽  
Photonic Biosensors

Enhancing the Sensitivity of Label-Free Silicon Photonic Biosensors through Increased Probe Molecule Density

ACS Photonics ◽  
2014 ◽  
Vol 1 (7) ◽  
pp. 590-597 ◽  
Author(s):  
Shuren Hu ◽  
Yiliang Zhao ◽  
Kun Qin ◽  
Scott T. Retterer ◽  
Ivan I. Kravchenko ◽  
...  
Keyword(s):  
Probe Molecule ◽  
Label Free ◽  
Free Silicon ◽  
Silicon Photonic ◽  
Photonic Biosensors

scholarly journals Erratum: Luan, E.X.; Shoman, H.; Ratner, D.M.; Cheung, K.C.; Chrostowski, L. Silicon Photonic Biosensors Using Label-Free Detection. Sensors 2018, 18, 3519

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1161 ◽  
Author(s):  
Enxiao Luan ◽  
Hossam Shoman ◽  
Daniel Ratner ◽  
Karen Cheung ◽  
Lukas Chrostowski
Keyword(s):  
Label Free ◽  
Silicon Photonic ◽  
Label Free Detection ◽  
Photonic Biosensors ◽  
Published Paper

The authors wish to make the following corrections in their published paper in Sensors [...]

scholarly journals Characterization of the evanescent field profile and bound mass sensitivity of a label-free silicon photonic microring resonator biosensing platform

2010 ◽  
Vol 26 (4) ◽  
pp. 1283-1291 ◽  
Author(s):  
Matthew S. Luchansky ◽  
Adam L. Washburn ◽  
Teresa A. Martin ◽  
Muzammil Iqbal ◽  
L. Cary Gunn ◽  
...  
Keyword(s):  
Evanescent Field ◽  
Microring Resonator ◽  
Field Profile ◽  
Label Free ◽  
Mass Sensitivity ◽  
Free Silicon ◽  
Silicon Photonic

scholarly journals Biochemistry strategies for label-free optical sensor biofunctionalization: advances towards real applicability

2021 ◽  
Author(s):  
Maria Soler ◽  
Laura M. Lechuga
Keyword(s):  
Industrial Applications ◽  
Clinical Diagnostics ◽  
Optical Biosensors ◽  
Special Focus ◽  
Analytical Sensitivity ◽  
Label Free ◽  
Functional Coatings ◽  
Innovative Strategies ◽  
Silicon Photonic ◽  
Sensitivity And Selectivity

AbstractLabel-free biosensors, and especially those based on optical transducers like plasmonic or silicon photonic systems, have positioned themselves as potential alternatives for rapid and highly sensitive clinical diagnostics, on-site environmental monitoring, and for quality control in foods or other industrial applications, among others. However, most of the biosensor technology has not yet been transferred and implemented in commercial products. Among the several causes behind that, a major challenge is the lack of standardized protocols for sensor biofunctionalization. In this review, we summarize the most common methodologies for sensor surface chemical modification and bioreceptor immobilization, discussing their advantages and limitations in terms of analytical sensitivity and selectivity, reproducibility, and versatility. Special focus is placed on the suggestions of innovative strategies towards antifouling and biomimetic functional coatings to boost the applicability and reliability of optical biosensors in clinics and biomedicine. Finally, a brief overview of research directions in the area of device integration, automation, and multiplexing will give a glimpse of the future perspectives for label-free optical biosensors.

scholarly journals Label-free silicon photonic biosensor system with integrated detector array

Lab on a Chip ◽  
2009 ◽  
Vol 9 (15) ◽  
pp. 2163 ◽  
Author(s):  
Rongjin Yan ◽  
Santano P. Mestas ◽  
Guangwei Yuan ◽  
Rashid Safaisini ◽  
David S. Dandy ◽  
...  
Keyword(s):  
Detector Array ◽  
Label Free ◽  
Free Silicon ◽  
Silicon Photonic ◽  
Biosensor System ◽  
Integrated Detector

Polymer-Decorated Carbon Nanotubes as Transducers for Label-Free Photonic Biosensors

2015 ◽  
Vol 21 (51) ◽  
pp. 18649-18653 ◽  
Author(s):  
Elise Villemin ◽  
Edmond Gravel ◽  
Nicolas Izard ◽  
Arianna Filoramo ◽  
Laurent Vivien ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Label Free ◽  
Photonic Biosensors

scholarly journals Multiplexed microRNA expression profiling by combined asymmetric PCR and label-free detection using silicon photonic sensor arrays

2018 ◽  
Vol 10 (14) ◽  
pp. 1618-1623 ◽  
Author(s):  
Richard M. Graybill ◽  
Maria C. Cardenosa-Rubio ◽  
Hongwei Yang ◽  
Mark D. Johnson ◽  
Ryan C. Bailey
Keyword(s):  
Polymerase Chain Reaction ◽  
Expression Profiling ◽  
Sensor Arrays ◽  
Label Free ◽  
Asymmetric Pcr ◽  
Chain Reaction ◽  
Photonic Sensor ◽  
Silicon Photonic ◽  
Label Free Detection ◽  
Polymerase Chain

Analysis methods based upon the quantitative, real-time polymerase chain reaction are extremely powerful; however, they face intrinsic limitations in terms of target multiplexing.

scholarly journals An Analysis of a Compact Label-Free Guiding-Wave Biosensor Based on a Semiconductor-Clad Dielectric Strip Waveguide

Sensors ◽  
2020 ◽  
Vol 20 (12) ◽  
pp. 3368 ◽  
Author(s):  
Carlos Angulo Barrios
Keyword(s):  
Limit Of Detection ◽  
Beam Propagation Method ◽  
Three Dimensional ◽  
Silicon Oxynitride ◽  
Practical Implementation ◽  
Label Free ◽  
Sensor Performance ◽  
Strip Waveguide ◽  
Fabrication Tolerances ◽  
Photonic Biosensors

In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagation method. The simulations indicate that a 20-μm-long device can exhibit a surface limit of detection of 3 ng/cm2 for avidin molecules in aqueous solution. The sensor performance compares well to those displayed by other photonic biosensors with much larger footprints. The fabrication tolerances have been also studied in order to analyze the feasibility of the practical implementation of the biosensor.

Label-free silicon nanodots featured ratiometric fluorescent aptasensor for lysosomal imaging and pH measurement

2017 ◽  
Vol 94 ◽  
pp. 478-484 ◽  
Author(s):  
Yanan Zhang ◽  
Shan Guo ◽  
Shibo Cheng ◽  
Xinghu Ji ◽  
Zhike He
Keyword(s):  
Ph Measurement ◽  
Label Free ◽  
Free Silicon ◽  
Fluorescent Aptasensor
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