scholarly journals Erratum: Luan, E.X.; Shoman, H.; Ratner, D.M.; Cheung, K.C.; Chrostowski, L. Silicon Photonic Biosensors Using Label-Free Detection. Sensors 2018, 18, 3519

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1161 ◽  
Author(s):  
Enxiao Luan ◽  
Hossam Shoman ◽  
Daniel Ratner ◽  
Karen Cheung ◽  
Lukas Chrostowski
Keyword(s):  
Label Free ◽  
Silicon Photonic ◽  
Label Free Detection ◽  
Photonic Biosensors ◽  
Published Paper

The authors wish to make the following corrections in their published paper in Sensors [...]

Label-free silicon photonic biosensors for use in clinical diagnostics

2013 ◽  
Author(s):  
Sahba Talebi Fard ◽  
Samantha M. Grist ◽  
Valentina Donzella ◽  
Shon A. Schmidt ◽  
Jonas Flueckiger ◽  
...  
Keyword(s):  
Clinical Diagnostics ◽  
Label Free ◽  
Free Silicon ◽  
Silicon Photonic ◽  
Photonic Biosensors

scholarly journals Multiplexed microRNA expression profiling by combined asymmetric PCR and label-free detection using silicon photonic sensor arrays

2018 ◽  
Vol 10 (14) ◽  
pp. 1618-1623 ◽  
Author(s):  
Richard M. Graybill ◽  
Maria C. Cardenosa-Rubio ◽  
Hongwei Yang ◽  
Mark D. Johnson ◽  
Ryan C. Bailey
Keyword(s):  
Polymerase Chain Reaction ◽  
Expression Profiling ◽  
Sensor Arrays ◽  
Label Free ◽  
Asymmetric Pcr ◽  
Chain Reaction ◽  
Photonic Sensor ◽  
Silicon Photonic ◽  
Label Free Detection ◽  
Polymerase Chain

Analysis methods based upon the quantitative, real-time polymerase chain reaction are extremely powerful; however, they face intrinsic limitations in terms of target multiplexing.

Enhancing the Sensitivity of Label-Free Silicon Photonic Biosensors through Increased Probe Molecule Density

ACS Photonics ◽  
2014 ◽  
Vol 1 (7) ◽  
pp. 590-597 ◽  
Author(s):  
Shuren Hu ◽  
Yiliang Zhao ◽  
Kun Qin ◽  
Scott T. Retterer ◽  
Ivan I. Kravchenko ◽  
...  
Keyword(s):  
Probe Molecule ◽  
Label Free ◽  
Free Silicon ◽  
Silicon Photonic ◽  
Photonic Biosensors

scholarly journals Silicon Photonic Micro-Ring Resonators for Chemical and Biological Sensing: A Tutorial

2021 ◽  
Author(s):  
Patrick Steglich ◽  
Dominik G. Rabus ◽  
Cinzia Sada ◽  
Martin Paul ◽  
Michael G. Weller ◽  
...  
Keyword(s):  
Free Surface ◽  
Limit Of Detection ◽  
Design Guidelines ◽  
Ring Resonators ◽  
Biological Sensing ◽  
Label Free ◽  
Sensing Applications ◽  
Silicon Photonic ◽  
Label Free Detection ◽  
Surface Sensing

Silicon photonic micro-ring resonators (MRR) developed on the silicon-on-insulator (SOI) platform, owing to their high sensitivity and small footprint, show great potential for many chemical and biological sensing applications such as label-free detection in environmental monitoring, biomedical engineering, and food analysis. In this tutorial, we provide the theoretical background and give design guidelines for SOI-based MRR as well as examples of surface functionalization procedures for label-free detection of molecules. <br>After introducing the advantages and perspectives of MRR, fundamentals of MRR are described in detail, followed by an introduction to the fabrication methods, which are based on a complementary metal-oxide semiconductor (CMOS) technology. Optimization of MRR for chemical and biological sensing is provided, with special emphasis on the optimization of waveguide geometry. At this point, the difference between chemical bulk sensing and label-free surface sensing is explained, and definitions like waveguide sensitivity, ring sensitivity, overall sensitivity as well as the limit of detection (LoD) of MRR are introduced. Further, we show and explain chemical bulk sensing of sodium chloride (NaCl) in water and provide a recipe for label-free surface sensing.

Label-free detection of the IL-6 and IL-8 interleukines through monolithic silicon photonic chips and simultaneous dual polarization optics

2018 ◽  
Vol 256 ◽  
pp. 304-309 ◽  
Author(s):  
M. Anastasopoulou ◽  
A. Malainou ◽  
A. Salapatas ◽  
N. Chronis ◽  
I. Raptis ◽  
...  
Keyword(s):  
Label Free ◽  
Dual Polarization ◽  
Silicon Photonic ◽  
Label Free Detection ◽  
Polarization Optics

scholarly journals The Role of Surface Chemistry in the Efficacy of Protein and DNA Microarrays for Label-Free Detection: An Overview

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1026
Author(s):  
Elisa Chiodi ◽  
Allison M. Marn ◽  
Matthew T. Geib ◽  
M. Selim Ünlü
Keyword(s):  
Surface Chemistry ◽  
Surface Functionalization ◽  
Dna Microarrays ◽  
Label Free ◽  
Polymeric Coatings ◽  
Label Free Detection ◽  
Particle Imaging ◽  
Single Particle Imaging ◽  
The Impact

The importance of microarrays in diagnostics and medicine has drastically increased in the last few years. Nevertheless, the efficiency of a microarray-based assay intrinsically depends on the density and functionality of the biorecognition elements immobilized onto each sensor spot. Recently, researchers have put effort into developing new functionalization strategies and technologies which provide efficient immobilization and stability of any sort of molecule. Here, we present an overview of the most widely used methods of surface functionalization of microarray substrates, as well as the most recent advances in the field, and compare their performance in terms of optimal immobilization of the bioreceptor molecules. We focus on label-free microarrays and, in particular, we aim to describe the impact of surface chemistry on two types of microarray-based sensors: microarrays for single particle imaging and for label-free measurements of binding kinetics. Both protein and DNA microarrays are taken into consideration, and the effect of different polymeric coatings on the molecules’ functionalities is critically analyzed.

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