Study of photodynamic therapy in skin cancers and precancerous lesions

1993 ◽  
Author(s):  
Jiabi Wang ◽  
Menglin Gao ◽  
Shijun Wen ◽  
Mianjing Wang
Keyword(s):  
Photodynamic Therapy ◽  
Precancerous Lesions ◽  
Skin Cancers

scholarly journals Efficacy of topical photodynamic therapy in the treatment of erythroplasia of Queyrat

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Massimo Iafrate ◽  
Mariangela Mancini ◽  
Tommaso Prayer Galetti ◽  
Serena Szekely ◽  
Edoardo Zattra ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Treatment ◽  
Precancerous Lesions ◽  
Treatment Modalities ◽  
Imiquimod Cream ◽  
Skin Cancers ◽  
Frequent Relapses ◽  
Erythroplasia Of Queyrat ◽  
Non Surgical Treatment

Erythroplasia of Queyrat (EQ) is an intraepidermal carcinoma in situ presenting clinically as a sharply demarcated, slightly raised erythematosus plaque on the glans penis or the inner side of the foreskin. Various treatment modalities for EQ have been proposed, including electrocautery and curettage, topical 5-floururacil cream, imiquimod cream, isotretinoin, cryotherapy, laser therapy, radiotherapy, ingenol mebutate gel and photodynamic therapy (PDT). Most of these treatments are limited by low clearance rates and frequent relapses. Surgical treatment including local excision, Mohs micrographic surgery and partial or total penectomy, ensures adequate healing rates. However, discomfort consequent to surgical treatment might be unacceptable. Topical PDT using the methyl ester of 5-aminolaevulinic acid (MAL) is an established non-surgical treatment of cutaneous precancerous lesions and skin cancers. We present the case of a 60-year-old uncircumcised man affected by EQ of the penis successfully treated with MAL-PDT, performed five times, two weeks apart, with no recurrences after 6 years.

Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors

2021 ◽  
Vol 22 ◽  
Author(s):  
Maria Bernadete Riemma Pierre
Keyword(s):  
Photodynamic Therapy ◽  
Drug Delivery Systems ◽  
Active Agent ◽  
Therapeutic Modality ◽  
Tissue Penetration ◽  
Promising Tool ◽  
Skin Cancers ◽  
Superficial Basal Cell Carcinoma ◽  
The Stability ◽  
Disor Ders

Abstract: Photodynamic Therapy (PDT) is a therapeutic modality used for several malignant and premalignant skin disor-ders, including Bowen's disease skin cancers and Superficial Basal Cell Carcinoma (BCC). Several photosensitizers (PSs) have been explored for tumor destruction of skin cancers, after their activation by a light source of appropriate wavelength. Topical release of PSs avoids prolonged photosensitization reactions associated with systemic administration; however, its clinical usefulness is influenced by its poor tissue penetration and the stability of the active agent. Nanotechnology-based drug delivery systems are promising tool to enhance the efficiency for PDT of cancer. This review focuses on PSs encap-sulated in nanocarriers explored for PDT of skin tumors.

scholarly journals Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Christina Wlodek ◽  
Faisal R. Ali ◽  
John T. Lear
Keyword(s):  
Photodynamic Therapy ◽  
Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Actinic Keratoses ◽  
Organ Transplant Recipients ◽  
Skin Cancers ◽  
Effective Treatment Modality ◽  
Nonmelanoma Skin Cancers

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.

Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy

2021 ◽  
Vol 28 ◽  
Author(s):  
Ivana Ratkaj ◽  
Martina Mušković ◽  
Nela Malatesti
Keyword(s):  
Photodynamic Therapy ◽  
Head And Neck ◽  
Tumour Progression ◽  
Neck Region ◽  
Angiogenesis Inhibitors ◽  
Tumour Microenvironment ◽  
Head And Neck Cancers ◽  
Skin Cancers ◽  
Tumour Vasculature ◽  
Optimal Drug

Background: Photodynamic therapy (PDT), in comparison to other skin cancers, is still far less effective for melanoma, due to the strong absorbance and the role of melanin in cytoprotection. The tumour microenvironment (TME) has a significant role in tumour progression, and the hypoxic TME is one of the main reasons for melanoma progression to metastasis and its resistance to PDT. Hypoxia is also a feature of solid tumours in the head and neck region that indicates a negative prognosis. Objective: The aim of this study was to individuate and describe systematically the main strategiesthe main strategies systematically in targeting the TME, especially hypoxia, in PDT against melanoma and head and neck cancers (HNC), and assess the current success in their application. Methods: PubMed, was used for searching, in MEDLINE and other databases were used for searching, for the most recent publications on PDT against melanoma and HNC in combination with the TME targeting and hypoxia. Results: In PDT for melanoma and HNC, it is very important to control hypoxia levels, and, amongst the different approaches, oxygen self-supply systems are often applied. Vascular targeting is promising, but to improve it, optimal drug-light interval, and formulation to increase the accumulation of the photosensitiser in the tumour vasculature, have to be established. On the other side, the use of angiogenesis inhibitors, such as those interfering with VEGF signalling are somewhat less successful than expected and need to be further investigated. Conclusion: Combination The combination of PDT with immunotherapy by using multifunctional nanoparticles continues to develop and seems to be the most promising for achieving a complete and lasting antitumour effect.

Skin cancers and precancerous lesions in Parkinson's disease patients

2007 ◽  
Vol 22 (10) ◽  
pp. 1471-1475 ◽  
Author(s):  
Joaquim Ferreira ◽  
João Maia Silva ◽  
Rita Freire ◽  
João Pignatelli ◽  
Leonor Correia Guedes ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Precancerous Lesions ◽  
Skin Cancers

scholarly journals Photodynamic Therapy for Low-grade Cervical Intraepithelial Neoplasia (CIN1): A Case Report

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yinyin Zhang ◽  
Hong Lin ◽  
Huizhen Fan
Keyword(s):  
Photodynamic Therapy ◽  
Cervical Intraepithelial Neoplasia ◽  
Persistent Infection ◽  
Precancerous Lesions ◽  
Irradiation Time ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Cervical Canal ◽  
Low Grade ◽  
Oxygen Inhalation

As a drug-mechanical combination technology, photodynamic (PDT) can achieve accurate and targeted therapy for malignant tumors and benign diseases through the production of reactive oxygen species, oxygen free radicals or singlet oxygen by photosensitizers at specific wavelengths. Compared with traditional surgery, it has the advantages of selective killing, repeatable treatment, preserving target organ function and so on. The purpose of this study was to explore the clinical value of photodynamic therapy in cervical precancerous lesions by taking the patients with low-grade cervical intraepithelial neoplasia (CIN1) with high-risk human papillomavirus (HR-HPV) persistent infection diagnosed by "three-step diagnosis and treatment procedure" as an example. Using HiPorfin as a photosensitizer, photodynamic therapy was performed 48 hours after intravenous drip. Set laser wavelength 630nm, light dose density 137.58J/cm2, transmission efficiency 1.42, output power 2w. 3cm columnar optical fiber was placed around the 2cm in the cervical canal to cover all the lesions, and the irradiation time was 900s (600s in the cervical canal and 300s outside the cervical canal). The patients were given oxygen inhalation for 6 hours after operation, and the patients were observed for itching and other discomfort, and paid attention to avoid light. Photodynamic therapy was performed again in the same way on the second day. After two months of treatment, pathological biopsy showed chronic cervicitis, indicating that the disease had been effectively controlled. Theoretically, although the patient is not the absolute indication of photodynamic therapy (that is, meeting CIN ? or CIN ?, having fertility requirements and not undergoing surgery), this therapy can remove not only the superficial lesions inside and outside the cervix, but also the potential lesions not found under colposcopy. It can also block the persistent infection of HPV by inhibiting the expression of HPV18, E6 and E7mRNA in Hela cells. In combination with Baofukang suppository, it can block HPV infection. Increase the negative conversion rate of cervical HPV and reduce the probability of recurrence after CIN1 cure. For young female patients with persistent HR-HPV infection and fertility requirements, photodynamic therapy is an effective choice for clinical treatment of CIN1.

Photodynamic Therapy of Skin Cancers: A New Therapeutic Alternative?

1997 ◽  
pp. 1288-1295
Author(s):  
R.-M. Szeimies ◽  
S. Karrer ◽  
W. Bäumler ◽  
C. Abels ◽  
M. Landthaler
Keyword(s):  
Photodynamic Therapy ◽  
Therapeutic Alternative ◽  
Skin Cancers

scholarly journals Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

2016 ◽  
Vol 7 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Kotya Naik Maloth ◽  
Nagalaxmi Velpula ◽  
Srikanth Kodangal ◽  
Mithare Sangmesh ◽  
Kiran Vellamchetla ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Treatment Modality ◽  
Precancerous Lesions ◽  
Invasive Treatment ◽  
Non Invasive

scholarly journals Techniques for fluorescence detection of protoporphyrin IX in skin cancers associated with photodynamic therapy

2013 ◽  
Vol 2 (4) ◽  
Author(s):  
Kishore R. Rollakanti ◽  
Stephen C. Kanick ◽  
Scott C. Davis ◽  
Brian W. Pogue ◽  
Edward V. Maytin
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Detection ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Skin Lesions ◽  
Wide Field ◽  
Detection Techniques ◽  
Current State ◽  
Therapeutic Outcomes ◽  
Skin Cancers

AbstractPhotodynamic therapy (PDT) is a treatment modality that uses a specific photosensitizing agent, molecular oxygen, and light of a particular wavelength to kill cells targeted by the therapy. Topically administered aminolevulinic acid (ALA) is widely used to effectively treat cancerous and precancerous skin lesions, resulting in targeted tissue damage and little to no scarring. The targeting aspect of the treatment arises from the fact that ALA is preferentially converted into protoporphyrin IX (PpIX) in neoplastic cells. To monitor the amount of PpIX in tissues, techniques have been developed to measure PpIX-specific fluorescence, which provides information useful for monitoring the abundance and location of the photosensitizer before and during the illumination phase of PDT. This review summarizes the current state of these fluorescence detection techniques. Non-invasive devices are available for point measurements, or for wide-field optical imaging, to enable monitoring of PpIX in superficial tissues. To gain access to information at greater tissue depths, multi-modal techniques are being developed which combine fluorescent measurements with ultrasound or optical coherence tomography, or with microscopic techniques such as confocal or multiphoton approaches. The tools available at present, and newer devices under development, offer the promise of better enabling clinicians to inform and guide PDT treatment planning, thereby optimizing therapeutic outcomes for patients.

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