scholarly journals Effective treatment of 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch precancerous lesions by topical photosan-mediated photodynamic therapy

Head & Neck ◽  
2011 ◽  
Vol 34 (4) ◽  
pp. 505-512 ◽  
Author(s):  
Chun-Pin Chiang ◽  
Wan-Ting Huang ◽  
Jeng-Woei Lee ◽  
Yih-Chih Hsu
Keyword(s):  
Photodynamic Therapy ◽  
Effective Treatment ◽  
Precancerous Lesions ◽  
Hamster Buccal Pouch

Vitamin D3–assisted chemo-photodynamic therapy of rhabdomyosarcoma cancer cells for effective treatment

2018 ◽  
Vol 15 (12) ◽  
pp. 125602
Author(s):  
R Mahmood ◽  
A Khurshid ◽  
J A Khan ◽  
M Rafi ◽  
M Aalam ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Effective Treatment ◽  
Cancer Cells ◽  
Vitamin D3

scholarly journals Photodynamic Therapy for Low-grade Cervical Intraepithelial Neoplasia (CIN1): A Case Report

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yinyin Zhang ◽  
Hong Lin ◽  
Huizhen Fan
Keyword(s):  
Photodynamic Therapy ◽  
Cervical Intraepithelial Neoplasia ◽  
Persistent Infection ◽  
Precancerous Lesions ◽  
Irradiation Time ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Cervical Canal ◽  
Low Grade ◽  
Oxygen Inhalation

As a drug-mechanical combination technology, photodynamic (PDT) can achieve accurate and targeted therapy for malignant tumors and benign diseases through the production of reactive oxygen species, oxygen free radicals or singlet oxygen by photosensitizers at specific wavelengths. Compared with traditional surgery, it has the advantages of selective killing, repeatable treatment, preserving target organ function and so on. The purpose of this study was to explore the clinical value of photodynamic therapy in cervical precancerous lesions by taking the patients with low-grade cervical intraepithelial neoplasia (CIN1) with high-risk human papillomavirus (HR-HPV) persistent infection diagnosed by "three-step diagnosis and treatment procedure" as an example. Using HiPorfin as a photosensitizer, photodynamic therapy was performed 48 hours after intravenous drip. Set laser wavelength 630nm, light dose density 137.58J/cm2, transmission efficiency 1.42, output power 2w. 3cm columnar optical fiber was placed around the 2cm in the cervical canal to cover all the lesions, and the irradiation time was 900s (600s in the cervical canal and 300s outside the cervical canal). The patients were given oxygen inhalation for 6 hours after operation, and the patients were observed for itching and other discomfort, and paid attention to avoid light. Photodynamic therapy was performed again in the same way on the second day. After two months of treatment, pathological biopsy showed chronic cervicitis, indicating that the disease had been effectively controlled. Theoretically, although the patient is not the absolute indication of photodynamic therapy (that is, meeting CIN ? or CIN ?, having fertility requirements and not undergoing surgery), this therapy can remove not only the superficial lesions inside and outside the cervix, but also the potential lesions not found under colposcopy. It can also block the persistent infection of HPV by inhibiting the expression of HPV18, E6 and E7mRNA in Hela cells. In combination with Baofukang suppository, it can block HPV infection. Increase the negative conversion rate of cervical HPV and reduce the probability of recurrence after CIN1 cure. For young female patients with persistent HR-HPV infection and fertility requirements, photodynamic therapy is an effective choice for clinical treatment of CIN1.

scholarly journals Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

2016 ◽  
Vol 7 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Kotya Naik Maloth ◽  
Nagalaxmi Velpula ◽  
Srikanth Kodangal ◽  
Mithare Sangmesh ◽  
Kiran Vellamchetla ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Treatment Modality ◽  
Precancerous Lesions ◽  
Invasive Treatment ◽  
Non Invasive

Study of photodynamic therapy in skin cancers and precancerous lesions

1993 ◽  
Author(s):  
Jiabi Wang ◽  
Menglin Gao ◽  
Shijun Wen ◽  
Mianjing Wang
Keyword(s):  
Photodynamic Therapy ◽  
Precancerous Lesions ◽  
Skin Cancers

scholarly journals Is Photodynamic Therapy an Effective Treatment for Periodontal and Peri-Implant Infections?

2015 ◽  
Vol 59 (4) ◽  
pp. 831-858 ◽  
Author(s):  
Anton Sculean ◽  
Akira Aoki ◽  
George Romanos ◽  
Frank Schwarz ◽  
Richard J. Miron ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Effective Treatment

scholarly journals Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Fernanda Lopes de Souza ◽  
Mariana Oliveira ◽  
Marianne Brochado Nunes ◽  
Lucas Horstmann Serafim ◽  
Alan Arrieira Azambuja ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Early Stage ◽  
Precancerous Lesions ◽  
Public Health Problem ◽  
Clinical Aspects ◽  
Carbamide Peroxide ◽  
Control Groups ◽  
Rete Ridge ◽  
Hamster Buccal Pouch ◽  
Epithelium Thickness

Oral squamous cell carcinoma (OSCC) is a public health problem. The hamster buccal pouch model is ideal for analyzing the development of OSCC. This research analysed the effects of sunitinib (tyrosine kinase inhibitor) in precancerous lesions induced by 7,12-dimethylbenz(a)anthracene (DMBA) in this model. Thirty-four male hamsters, divided into six groups: control—C n=7, acetone—A n=12, carbamide peroxide—CP n=5, acetone and CP—A+CP n=8, 1% DMBA in acetone and CP—DA+CP n=6, and 1% DMBA in acetone and CP and 4-week treatment with sunitinib—DA+CP+S n=7. The aspects evaluated were anatomopathological features (peribuccal area, paws, nose, and fur), histological sections of the hamster buccal pouches (qualitatively analyzed), epithelium thickness, and the rete ridge density (estimated). Sunitinib was unable to attenuate the decrease in weight gain induced by DMBA; no increase in volume was detected in the pouch and/or ulceration, observed in 43% of the animals in the DA+CP group. DA+CP groups presented a significant increase in rete ridge density compared to the control groups (P<0.01) which was reverted by sunitinib in the DA+CP+S group. Sunitinib seems to have important benefits in early stage carcinogenesis and may be useful in chemoprevention.

Photodynamic therapy for actinic keratosis of the forehead and scalp with the Aktilite CL 128: Is there a cut-off value for PpIX-weighted irradiance for effective treatment?

2019 ◽  
Vol 35 (4) ◽  
pp. 232-237 ◽  
Author(s):  
Claire Vicentini ◽  
Anne-Sophie Vignion-Dewalle ◽  
Elise Thecua ◽  
Fabienne Lecomte ◽  
Hélène Béhal ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Effective Treatment ◽  
Actinic Keratosis
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