scholarly journals Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

2016 ◽  
Vol 7 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Kotya Naik Maloth ◽  
Nagalaxmi Velpula ◽  
Srikanth Kodangal ◽  
Mithare Sangmesh ◽  
Kiran Vellamchetla ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Treatment Modality ◽  
Precancerous Lesions ◽  
Invasive Treatment ◽  
Non Invasive

scholarly journals Utility of Photodynamic Therapy in Dentistry: Current Concepts

2020 ◽  
Vol 8 (2) ◽  
pp. 43
Author(s):  
Anette Stájer ◽  
Szilvia Kajári ◽  
Márió Gajdács ◽  
Aima Musah-Eroje ◽  
Zoltán Baráth
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Success ◽  
Maxillofacial Surgery ◽  
Treatment Method ◽  
Treatment Modalities ◽  
Oral And Maxillofacial Surgery ◽  
Invasive Treatment ◽  
Advantages And Disadvantages ◽  
Non Invasive ◽  
Wide Range

The significant growth in scientific and technological advancements within the field of dentistry has resulted in a wide range of novel treatment modalities for dentists to use. Photodynamic therapy (PDT) is an emerging, non-invasive treatment method, involving photosensitizers, light of a specific wavelength and the generation of singlet oxygen and reactive oxygen species (ROS) to eliminate unwanted eukaryotic cells (e.g., malignancies in the oral cavity) or pathogenic microorganisms. The aim of this review article is to summarize the history, general concepts, advantages and disadvantages of PDT and to provide examples for current indications of PDT in various subspecialties of dentistry (oral and maxillofacial surgery, oral medicine, endodontics, preventive dentistry, periodontology and implantology), in addition to presenting some images from our own experiences about the clinical success with PDT.

Pi-stacking interaction perphenazine modified zinc(II) phthalocyanine nanoparticles for photothermal and photodynamic therapy

2020 ◽  
pp. A-E
Author(s):  
Mack Biyiklioglu
Keyword(s):  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Inhibition Efficiency ◽  
Active Oxygen ◽  
Photothermal Effect ◽  
Invasive Treatment ◽  
Pi Stacking ◽  
Non Invasive ◽  
Targeting Effect

Photodynamic therapy and photothermal therapy as non-invasive treatment methods have been receiving more and more attention. The report shows that zinc(II) phthalocyanine (Pc2) modified by perphenazine forms nanoparticles with a particle size of 110 nm by [Formula: see text]–[Formula: see text] stacking in water. It has good photothermal effect when illuminated by 680 nm laser in aqueous solution. In addition, its ability to produce active oxygen is 2.3-fold that of methylene blue, so Pc2 also has a good photodynamic effect. In vivo fluorescence shows that Pc2 has a good targeting effect on tumors. Under the synergistic effect of photodynamic therapy and photothermal therapy, Pc2 has good tumor inhibition efficiency.

scholarly journals Electron Transfer-Supported Photodynamic Therapy

2020 ◽  
Author(s):  
Kazutaka Hirakawa
Keyword(s):  
Electron Transfer ◽  
Photodynamic Therapy ◽  
Energy Transfer ◽  
Precancerous Lesions ◽  
Hypoxic Condition ◽  
Protein Damage ◽  
Free Base ◽  
Invasive Treatment ◽  
Porphyrin Derivatives ◽  
Mediated Oxidation

Photodynamic therapy (PDT) is a less-invasive treatment of cancer and precancerous lesions. Porphyrin derivatives have been used and studied as the photosensitizers for PDT. In general, the biomacromolecules oxidation by singlet oxygen, which is produced through energy transfer from the photoexcited photosensitizers to oxygen molecules, is an important mechanism of PDT. However, the traditional PDT effect may be restricted, because tumors are in a hypoxic condition and in certain cases, PDT enhances hypoxia via vascular damage. To solve this problem, the electron transfer-mediated oxidation of biomolecules has been proposed as the PDT mechanism. Specifically, porphyrin phosphorus(V) complexes demonstrate relatively strong photooxidative activity in protein damage through electron transfer. Furthermore, other photosensitizers, e.g., cationic free-base porphyrins, can oxidize biomolecules through electron transfer. The electron transfer-supported PDT may play the important roles in hypoxia cancer therapy. Furthermore, the electron transfer-supported mechanism may contribute to antimicrobial PDT. In this chapter, recent topics about the biomolecules photooxidation by electron transfer-supported mechanism are reviewed.

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