Fluorescence imaging method for in vivo pH monitoring during liposomes uptake in rat liver using a pH-sensitive fluorescent dye

2005 ◽  
Vol 10 (2) ◽  
pp. 024008 ◽  
Author(s):  
S. Begu ◽  
S. Mordon ◽  
T. Desmettre ◽  
J. M. Devoisselle
Keyword(s):  
Fluorescence Imaging ◽  
Rat Liver ◽  
Ph Monitoring ◽  
Ph Sensitive ◽  
Fluorescent Dye ◽  
Imaging Method

The use of pH-sensitive functional selenium nanoparticles shows enhanced in vivo VEGF-siRNA silencing and fluorescence imaging

Nanoscale ◽  
2014 ◽  
Vol 6 (15) ◽  
pp. 9279-9292 ◽  
Author(s):  
Qianqian Yu ◽  
Yanan Liu ◽  
Chengwen Cao ◽  
Fangling Le ◽  
Xiuying Qin ◽  
...  
Keyword(s):  
Side Effects ◽  
Gene Silencing ◽  
Fluorescence Imaging ◽  
Delivery System ◽  
Ph Sensitive ◽  
Selenium Nanoparticles ◽  
Vegf Gene ◽  
Sirna Silencing

The pH-sensitive delivery system G2/PAH-Cit/SeNPs@siRNA enhances anti-tumor effects through VEGF gene silencing and reduces angiogenesis, with no side effects in organs.

scholarly journals Imaging of Metastatic Cancer Cells in Sentinel Lymph Nodes using Affibody Probes and Possibility of a Theranostic Approach

2019 ◽  
Vol 20 (2) ◽  
pp. 427 ◽  
Author(s):  
Makoto Tsuchimochi ◽  
Haruka Yamaguchi ◽  
Kazuhide Hayama ◽  
Yasuo Okada ◽  
Tomoyuki Kawase ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Metastatic Cancer ◽  
Imaging Method ◽  
Two Stage ◽  
Metastatic Lymph Nodes ◽  
Nir Fluorescence

The accurate detection of lymph node metastases is essential for treatment success in early-stage malignant cancer. Sentinel lymph node (SLN) biopsy is the most effective procedure for detecting small or micrometastases that are undetectable by conventional imaging modalities. To demonstrate a new approach for developing a more efficient SLN biopsy procedure, we reported a two-stage imaging method combining lymphoscintigraphy and near-infrared (NIR) fluorescence imaging to depict metastatic cancer cells in SLNs in vivo. Furthermore, the theranostic potential of the combined procedure was examined by cell culture and xenograft mouse model. Anti-HER2 and anti-epidermal growth factor receptor (EGFR) affibody probes were used for NIR fluorescence imaging. Strong NIR fluorescence signal intensity of the anti-EGFR affibody probe was observed in SAS cells (EGFR positive). Radioactivity in the SLNs was clearly observed in the in vivo studies. High anti-EGFR affibody NIR fluorescence intensity was observed in the metastatic lymph nodes in mice. The addition of the IR700-conjugated anti-EGFR affibody to the culture medium decreased the proliferation of SAS cells. Decreased proliferation was shown in Ki-67 immunohistochemistry in xenograft tumors. Our data suggest that a two-stage combined imaging method using lymphoscintigraphy and affibody probes may offer the direct visualization of metastatic lymph nodes as an easily applied technique in SLN biopsy. Although further animal studies are required to assess the effect of treating lymphatic metastasis in this approach, our study results provide a foundation for the further development of this promising imaging and treatment strategy for earlier lymph node metastasis detection and treatment.

Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent

2019 ◽  
Vol 7 (46) ◽  
pp. 7326-7331
Author(s):  
Sang Bong Lee ◽  
Ye Ri Han ◽  
Hui-Jeon Jeon ◽  
Chul-Ho Jun ◽  
Sang-Kyoon Kim ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Fluorescence Imaging ◽  
Fluorescent Dye ◽  
Imaging Agent ◽  
The Novel ◽  
Inflammatory Lesions ◽  
Inflammatory Drug ◽  
Inflammation Imaging ◽  
Anti Inflammatory

The novel fluorescent dye MF1 allows in vivo visualization of inflammatory lesions as well as the response to anti-inflammatory drug treatment by fluorescence imaging.

Rhodamine based pH-sensitive “intelligent” polymers as lysosome targeting probes and their imaging applications in vivo

2014 ◽  
Vol 5 (19) ◽  
pp. 5804-5812 ◽  
Author(s):  
Kang-Kang Yu ◽  
Kun Li ◽  
Ji-Ting Hou ◽  
Jin Yang ◽  
Yong-Mei Xie ◽  
...  
Keyword(s):  
Free Radical ◽  
Fluorescence Imaging ◽  
Radical Polymerization ◽  
Nude Mice ◽  
Free Radical Polymerization ◽  
Ph Sensitive ◽  
Ph Sensitivity ◽  
Cancerous Tissue ◽  
Intelligent Polymers

Two rhodamine-based polymers were prepared via free radical polymerization and could serve as lysosome targeting probes with good pH sensitivity. Fluorescence imaging of nude mice displayed a chance for visualization of cancerous tissue in vivo by sensing its acidic microenvironments.

Developing a pH-sensitive Al(OH)3 layer-mediated UCNP@Al(OH)3/Au nanohybrid for photothermal therapy and fluorescence imaging in vivo

2018 ◽  
Vol 6 (47) ◽  
pp. 7862-7870 ◽  
Author(s):  
Jian Chen ◽  
Dongya Zhang ◽  
Yan Zou ◽  
Zhongjie Wang ◽  
Mingcong Hao ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Ph Sensitive ◽  
Upconversion Nanoparticles ◽  
Ph Responsive

A pH-responsive and hydrophilic Al(OH)3 mediating layer makes possible the promising integration of photothermal therapy and fluorescence imaging based on upconversion nanoparticles (UCNPs).

Effect of X-irradiation on gene expression of rat liver chemokines: in vivo and in vitro studies

2008 ◽  
Vol 46 (01) ◽  
Author(s):  
F Moriconi ◽  
H Christiansen ◽  
H Christiansen ◽  
N Sheikh ◽  
J Dudas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
In Vitro Studies ◽  
X Irradiation

Chronic, in vivo, PPARα activation prevents lipid overload in rat liver induced by high fat feeding

2009 ◽  
Vol 54 (1) ◽  
Author(s):  
M Wierzbicki ◽  
A Chabowski ◽  
M Żendzian-Piotrowska ◽  
E Harasim ◽  
J Górski
Keyword(s):  
Rat Liver ◽  
High Fat ◽  
Fat Feeding
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