Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent

2019 ◽  
Vol 7 (46) ◽  
pp. 7326-7331
Author(s):  
Sang Bong Lee ◽  
Ye Ri Han ◽  
Hui-Jeon Jeon ◽  
Chul-Ho Jun ◽  
Sang-Kyoon Kim ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Fluorescence Imaging ◽  
Fluorescent Dye ◽  
Imaging Agent ◽  
The Novel ◽  
Inflammatory Lesions ◽  
Inflammatory Drug ◽  
Inflammation Imaging ◽  
Anti Inflammatory

The novel fluorescent dye MF1 allows in vivo visualization of inflammatory lesions as well as the response to anti-inflammatory drug treatment by fluorescence imaging.

Gram-scale synthesis of a neodymium chelate as a spectral CT and second near-infrared window imaging agent for visualizing the gastrointestinal tract in vivo

2021 ◽  
Author(s):  
Pengrui Zhuang ◽  
Ke Xiang ◽  
Xiangxi Meng ◽  
Guohe Wang ◽  
Ziyuan Li ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Fluorescence Imaging ◽  
Large Scale ◽  
Near Infrared ◽  
Imaging Agent ◽  
Spectral Ct ◽  
Green Method ◽  
Infrared Window

A facile and green method was developed to fabricate Nd-DTPA on a large scale without byproducts for CT/spectral CT and NIR II fluorescence imaging of the gastrointestinal tract in vivo.

Prognostic impact of pericardial drainage and anti-inflammatory drug treatment in severe idiopathic pericardial effusion

2020 ◽  
Vol 55 (2) ◽  
pp. 86-93
Author(s):  
Alejandro Cruz-Utrilla ◽  
Carlos Ferrera ◽  
Marcos Ferrández-Escarabajal ◽  
Cristina Sánchez-Enrique ◽  
Iván Núñez-Gil ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Drug Treatment ◽  
Prognostic Impact ◽  
Inflammatory Drug ◽  
Pericardial Drainage ◽  
Anti Inflammatory

scholarly journals Reversion of antibiotic resistance in drug-resistant bacteria using non-steroidal anti-inflammatory drug benzydamine

2021 ◽  
Author(s):  
Yuan Liu ◽  
Ziwen Tong ◽  
Jingru Shi ◽  
Tian Deng ◽  
Ruichao Li ◽  
...  
Keyword(s):  
Cost Effective ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Inflammatory Drug ◽  
Development Of Resistance ◽  
Drug Resistant Bacteria ◽  
Metabolic States ◽  
Anti Inflammatory ◽  
Approved Drugs

Antimicrobial resistance has been a growing concern that gradually undermines our tradition treatment regimen. The fact that few antibacterial drugs with new scaffolds or targets have been approved in the past two decades aggravates this crisis. Repurposing previously approved drugs as potent antibiotic adjuvants offers a cost effective strategy to mitigate the development of resistance and tackle the increasing infections by multidrug resistant (MDR) bacteria. Herein, we found that benzydamine, a widely used non-steroidal anti-inflammatory drug in clinic, remarkably potentiated broad spectrum antibiotic tetracyclines activity against a panel of clinical important resistant pathogens, including MRSA, VRE, MCRPEC and tet (X)-positive Gram negative bacteria. Further mechanistically experiments showed that benzydamine dissipated membrane potential (ΔΨ) in both Gram positive and negative bacteria, which in turn upregulated the transmembrane proton gradient (ΔpH) and promoted the uptake of tetracyclines. Additionally, benzydamine exacerbated the oxidative stress by triggering the production of ROS and suppressing GAD system mediated oxidative defensive. This mode of action explains the great bactericidal activity of the doxycycline benzydamine combination against different metabolic states of bacteria including persister cells. As a proof of concept, the in vivo efficacy of this combination therapy was evidenced in multiple animal infection models. These findings revealed that benzydamine is a promising tetracycline antibiotics adjuvant and has the potential to address life threatening infections by MDR bacteria.

scholarly journals The Effects of Anti-inflammatory Drug Treatment in Gastric Cancer Prevention: an Update of a Meta-analysis

2016 ◽  
Vol 7 (15) ◽  
pp. 2247-2257 ◽  
Author(s):  
Pengfei Kong ◽  
Ruiyan Wu ◽  
Xuechao Liu ◽  
Jianjun Liu ◽  
Shangxiang Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Treatment ◽  
Cancer Prevention ◽  
Meta Analysis ◽  
Inflammatory Drug ◽  
Gastric Cancer Prevention ◽  
Anti Inflammatory

Development, in-vitro and in-vivo characterization of gelatin nanoparticles for delivery of an anti-inflammatory drug

2016 ◽  
Vol 36 ◽  
pp. 55-61 ◽  
Author(s):  
Alok Mahor ◽  
Sunil Kumar Prajapati ◽  
Amita Verma ◽  
Rishikesh Gupta ◽  
Thakur Raghu Raj Singh ◽  
...  
Keyword(s):  
Gelatin Nanoparticles ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Development In Vitro ◽  
In Vivo Characterization

scholarly journals Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
P. Skopiński ◽  
B. J. Bałan ◽  
J. Kocik ◽  
R. Zdanowski ◽  
S. Lewicki ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Angiogenesis ◽  
Herbal Remedy ◽  
Inhibitory Effect ◽  
Inflammatory Drug ◽  
Anticancer Effects ◽  
Biologic Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Anticancer activity of many herbs was observed for hundreds of years. They act as modifiers of biologic response, and their effectiveness may be increased by combining multiple herbal extracts . PERVIVO, traditional digestive herbal remedy, contains some of them, and we previously described its antiangiogenic activity. Numerous studies documented anticancer effects of nonsteroidal anti-inflammatory drugs. We were the first to show that sulindac and its metabolites inhibit angiogenesis. In the present paper the combinedin vivoeffect of multicomponent herbal remedy PERVIVO and nonsteroidal anti-inflammatory drug sulindac on tumor growth, tumor angiogenesis, and tumor volume in Balb/c mice was studied. These effects were checked after grafting cells collected from syngeneic sarcoma L-1 tumors into mice skin. The strongest inhibitory effect was observed in experimental groups treated with PERVIVO and sulindac together. The results of our investigation showed that combined effect of examined drugs may be the best way to get the strongest antiangiogenic and antitumor effect.

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