Rhodamine based pH-sensitive “intelligent” polymers as lysosome targeting probes and their imaging applications in vivo

2014 ◽  
Vol 5 (19) ◽  
pp. 5804-5812 ◽  
Author(s):  
Kang-Kang Yu ◽  
Kun Li ◽  
Ji-Ting Hou ◽  
Jin Yang ◽  
Yong-Mei Xie ◽  
...  
Keyword(s):  
Free Radical ◽  
Fluorescence Imaging ◽  
Radical Polymerization ◽  
Nude Mice ◽  
Free Radical Polymerization ◽  
Ph Sensitive ◽  
Ph Sensitivity ◽  
Cancerous Tissue ◽  
Intelligent Polymers

Two rhodamine-based polymers were prepared via free radical polymerization and could serve as lysosome targeting probes with good pH sensitivity. Fluorescence imaging of nude mice displayed a chance for visualization of cancerous tissue in vivo by sensing its acidic microenvironments.

Investigation on pH-switchable (itaconic acid/ethylene glycol/acrylic acid) based polymeric biocompatible hydrogel

RSC Advances ◽  
2016 ◽  
Vol 6 (108) ◽  
pp. 106821-106831 ◽  
Author(s):  
M. Sakthivel ◽  
D. S. Franklin ◽  
S. Sudarsan ◽  
G. Chitra ◽  
S. Guhanathan
Keyword(s):  
Free Radical ◽  
Acrylic Acid ◽  
Ethylene Glycol ◽  
Radical Polymerization ◽  
Itaconic Acid ◽  
Free Radical Polymerization ◽  
Ph Sensitive ◽  
Water Medium ◽  
New Variety ◽  
Polymeric Hydrogels

A new variety of pH-sensitive polymeric hydrogels (IAE) have been developed and evaluated as biocompatible hydrogels using synergetic combinations of itaconic acid (IA), acrylic acid (AA), and ethylene glycol (EG) in water medium by free radical polymerization.

scholarly journals The Comparison of In Vivo Properties of Water-Soluble HPMA-Based Polymer Conjugates with Doxorubicin Prepared by Controlled RAFT or Free Radical Polymerization

2015 ◽  
pp. S41-S49 ◽  
Author(s):  
P. CHYTIL ◽  
M. ŠÍROVÁ ◽  
E. KOZIOLOVÁ ◽  
K. ULBRICH ◽  
B. ŘÍHOVÁ ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Polymerization ◽  
Accumulation Rate ◽  
Free Radical Polymerization ◽  
Drug Carriers ◽  
Water Soluble ◽  
Polymer Carrier ◽  
High Dispersity ◽  
Tumor Accumulation

Two conjugates of anticancer drug doxorubicin (Dox) covalently bound by the hydrolytically degradable hydrazone bond to the polymer carrier based on water-soluble N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers were synthesized and their properties were compared, namely their behavior in vivo. The polymer carriers differed in dispersity due to different methods of synthesis; the carrier with relatively high dispersity (HD) was prepared by free radical polymerization (Mw = 29 900 g/mol, Ð = 1.75) and the carrier with low dispersity (LD) by controlled radical polymerization (Mw = 30 000 g/mol, Ð = 1.13). Both polymer-Dox conjugates showed prolonged blood circulation and tumor accumulation of the drug in comparison with the free drug; e.g. the tumor-to-blood ratio for the polymer-bound Dox was 3-5 times higher. The LD polymer-Dox conjugate exhibited moderately higher tumor accumulation than the HD one at a dose of 1 x 15 mg Dox (eq.)/kg. Also, their anti-tumor activity did not differ when injected at this dose. However, the increase of the dose to 1 x 25 mg Dox (eq.)/kg resulted in the enhanced therapeutic activity of the conjugates, especially of the LD one with 100 % of long-term survivals. The dispersity of polymer drug carriers influenced the tumor accumulation rate, which affected the overall anti-cancer activity of polymer-drug conjugates.

Non-isothermal Kinetics of Free Radical Polymerization of 2-Phenylethyl (Meth)acrylate

2018 ◽  
Vol 8 (3) ◽  
pp. 585-594
Author(s):  
Khdbudin Mulani ◽  
Ravindra Ghorpade ◽  
Surendra Ponrathnam ◽  
Nayaku Chavan ◽  
Kamini Donde
Keyword(s):  
Free Radical ◽  
Radical Polymerization ◽  
Free Radical Polymerization ◽  
Isothermal Kinetics ◽  
Kinetics Of

Oxygen-Initiated Free-Radical Polymerization of Alkyl Acrylates at High Temperatures

2021 ◽  
Author(s):  
Shi Liu ◽  
Lauren Chua ◽  
Ahmad Arabi Shamsabadi ◽  
Patrick Corcoran ◽  
Abhirup Patra ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Polymerization ◽  
High Temperatures ◽  
Free Radical Polymerization ◽  
Alkyl Acrylates

Development of Novel Colorimetric Thermometer Based on Poly(N-vinylcaprolactam) with Push-π-Pull Tricyanofuran Hydrazone Anion Dye

2021 ◽  
Author(s):  
Meram S Abdelrahman ◽  
Tawfik A Khattab ◽  
Samir Kamel
Keyword(s):  
Free Radical ◽  
Radical Polymerization ◽  
Free Radical Polymerization

Thermochromic poly(N-vinylcaprolactam-co-tricyanofuran hydrazone) [Poly(VC-co-TCFH)] gel labeled with halochromic chromophore was developed using traditional free radical polymerization. Novel vinyl-containing tricyanofuran hydrazone (TCFH) halochromic chromophore bearing a hydrazone sensor group was generated...

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