Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acids

2003 ◽  
Vol 8 (2) ◽  
pp. 316 ◽  
Author(s):  
Patrick D. O’Neal ◽  
Massoud Motamedi ◽  
Wei-Chiang Lin ◽  
Jefferson Chen ◽  
Gerard L. Coté
Keyword(s):  
Amino Acids ◽  
Raman Spectroscopy ◽  
Feasibility Study ◽  
Excitatory Amino Acids ◽  
Surface Enhanced Raman Spectroscopy ◽  
Quantitative Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Multivariate Analysis Aided Surface-Enhanced Raman Spectroscopy (MVA-SERS) Multiplex Quantitative Detection of Trace Fentanyl in Illicit Drug Mixtures Using a Handheld Raman Spectrometer

2021 ◽  
pp. 000370282110329
Author(s):  
Ling Wang ◽  
Mario O. Vendrell-Dones ◽  
Chiara Deriu ◽  
Sevde Doğruer ◽  
Peter de B. Harrington ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Principal Component ◽  
Surface Enhanced Raman Spectroscopy ◽  
Quantitative Detection ◽  
Least Squares Regression ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Current Screening

Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy (SERS) provides a useful alternative to current screening procedures that permits detection of trace levels of fentanyl in mixtures. Samples are solubilized and allowed to interact with aggregated colloidal nanostars to produce a rapid and sensitive assay. In this study, we present the quantitative determination of fentanyl in heroin and cocaine using SERS, using a point-and-shoot handheld Raman system. Our protocol is optimized to detect pure fentanyl down to 0.20 ± 0.06 ng/mL and can also distinguish pure cocaine and heroin at ng/mL levels. Multiplex analysis of mixtures is enabled by combining SERS detection with principal component analysis and super partial least squares regression discriminate analysis (SPLS-DA), which allow for the determination of fentanyl as low as 0.05% in simulated seized heroin and 0.10% in simulated seized cocaine samples.

scholarly journals Dual-triggered nanoaggregates of cucurbit[7]uril and gold nanoparticles for multi-spectroscopic quantification of creatinine in urinalysis

2020 ◽  
Vol 8 (21) ◽  
pp. 7051-7058
Author(s):  
Weng-I Katherine Chio ◽  
Suresh Moorthy ◽  
Jayakumar Perumal ◽  
Dinish U. S. ◽  
Ivan P. Parkin ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Quantitative Detection ◽  
Vis Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

A novel nanosensing platform was developed for the quantitative detection of creatinine of clinically relevant concentrations via UV-Vis spectroscopy and surface-enhanced Raman spectroscopy.

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