Surface-enhanced Raman spectroscopy for the in-vitro and ex-vivo detection of excitatory amino acids

1999 ◽  
Author(s):  
D. P. O'Neal ◽  
Massoud Motamedi ◽  
Jefferson Chen ◽  
Gerard L. Cote
Keyword(s):  
Amino Acids ◽  
Raman Spectroscopy ◽  
Excitatory Amino Acids ◽  
Ex Vivo ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1145 ◽  
Author(s):  
Shuvashis Dey ◽  
Matt Trau ◽  
Kevin M. Koo
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Immunotherapy ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Checkpoint Receptors

Cancer immunotherapy encompasses a variety of approaches which target or use a patient’s immune system components to eliminate cancer. Notably, the current use of immune checkpoint inhibitors to target immune checkpoint receptors such as CTLA-4 or PD-1 has led to remarkable treatment responses in a variety of cancers. To predict cancer patients’ immunotherapy responses effectively and efficiently, multiplexed immunoassays have been shown to be advantageous in sensing multiple immunomarkers of the tumor microenvironment simultaneously for patient stratification. Surface-enhanced Raman spectroscopy (SERS) is well-regarded for its capabilities in multiplexed bioassays and has been increasingly demonstrated in cancer immunotherapy applications in recent years. This review focuses on SERS-active nanomaterials in the modern literature which have shown promise for enabling cancer patient-tailored immunotherapies, including multiplexed in vitro and in vivo immunomarker sensing and imaging, as well as immunotherapy drug screening and delivery.

scholarly journals SERS study on myeloperoxidase and its immunocomplex: Identification of binding interactions

2010 ◽  
Vol 24 (3-4) ◽  
pp. 183-190
Author(s):  
Elisabeth S. Papazoglou ◽  
Sundar Babu ◽  
David R. Hansberry ◽  
Sakya Mohapatra ◽  
Chirag Patel
Keyword(s):  
Amino Acids ◽  
Raman Spectroscopy ◽  
Conformational Changes ◽  
Surface Enhanced Raman Spectroscopy ◽  
Biological Molecules ◽  
Sers Spectrum ◽  
Amino Acid Residues ◽  
Igg Antibodies ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Surface Enhanced Raman Spectroscopy (SERS) has demonstrated significant benefit in the identification of biological molecules. In this paper we have examined how to identify and differentiate the 150 kDa protein myeloperoxidase (MPO) from its corresponding antibody (Ab) and their immunocomplex through the use of SERS. The SERS signal of these biological molecules was enabled by 40 nm gold nanoparticles. The SERS spectra for both MPO and the Ab (an IgG molecule) demonstrated results consistent with previous published work on the Raman spectra of MPO and IgG antibodies. The immunocomplex SERS spectra showed peak shifts and intensity variations that could be attributed to conformational changes that occur during immunocomplex formation. Several key spectral areas have been identified which correspond to specific amino acids being shielded from undergoing resonance while new amino acid residues are made visible in the SERS spectrum of the immunocomplex and could be a result of conformational binding. These results indicate that SERS can be used to identify binding events and distinguish an immunocomplex from its individual components.

NIR surface enhanced Raman spectroscopy and bands assignment by DFT calculations of non-natural β-amino acids

2005 ◽  
Vol 310 (1-3) ◽  
pp. 189-199 ◽  
Author(s):  
T. Iliescu ◽  
D. Maniu ◽  
V. Chis ◽  
F.D. Irimie ◽  
Cs. Paizs ◽  
...  
Keyword(s):  
Amino Acids ◽  
Raman Spectroscopy ◽  
Dft Calculations ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Stable Ag@Oxides Nanoplates for Surface-Enhanced Raman Spectroscopy of Amino Acids

2014 ◽  
Vol 6 (11) ◽  
pp. 8853-8858 ◽  
Author(s):  
Peng Du ◽  
Lan Ma ◽  
Yinghui Cao ◽  
Di Li ◽  
Zhenyu Liu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman
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