Single-pass forming for three-dimensional microstructures by high-speed shearing of multilayer thin films

Author(s):  
Tetsuya Hamaguchi ◽  
Hiroki Yonemoto ◽  
Keisuke Nagato ◽  
Kensuke Tsuchiya ◽  
Masayuki Nakao
Sensor Review ◽  
2018 ◽  
Vol 38 (1) ◽  
pp. 106-116 ◽  
Author(s):  
Nur Alia Sheh Omar ◽  
Yap Wing Fen

Purpose This paper aims to review the potential application of surface plasmon resonance (SPR) in diagnosis of dengue virus (DENV-2) E-protein and the development of SPR to become an alternative DENV sensor. Design/methodology/approach In this review, the existing standard laboratory techniques to diagnosis of DENV are discussed, together with their drawbacks. To overcome these drawbacks, SPR has been aimed to be a valuable optical biosensor for identification of antibodies to the DENV antigen. The review also includes the future studies on three-dimensional poly(amidoamine) (PAMAM) dendrimer-surface-assembled monolayer (SAM)-Au multilayer thin films, which are envisaged to have high potential sensitive and selective detection ability toward target E-proteins. Findings Application of SPR in diagnosis of DENV emerged over recent years. A wide range of immobilized biorecognition molecules have been developed to combine with SPR as an effective sensor. The detection limit, sensitivity and selectivity of SPR sensing in DENV have been enhanced from time to time, until the present. Originality/value The main purpose of this review is to provide authors with up-to-date and useful information on sensing DENV using SPR and to introduce a novel three-dimensional PAMAM-SAM-Au multilayer thin films for future research on SPR sensing applications.


Nanoscale ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 1196-1206 ◽  
Author(s):  
Jayakumar Kumarasamy ◽  
María Belén Camarada ◽  
Dharuman Venkatraman ◽  
Huangxian Ju ◽  
Ramendra Sundar Dey ◽  
...  

One-step coelectrodeposition-assisted layer-by-layer assembly was employed for preparing multilayer thin films with a controlled three-dimensional nanoarchitecture and application in an ultrasensitive DNA biosensor.


2009 ◽  
Vol 48 (8) ◽  
pp. 08HG01 ◽  
Author(s):  
Myung Jin Lee ◽  
Jae Sung Kim ◽  
Ki-Young Kwak ◽  
Nam-Ki Min

A study has been made of the growth of explosion in thin films and also three-dimensional charges of liquid explosives including nitroglycerine, nitromethane‒nitric acid mixtures, hydrogen peroxide‒ethanol mixtures and diethyleneglycol dinitrate (DEGDN). Observation was by high-speed photography at microsecond framing rates. In the thin film experiments burning was initiated at the centre of the film by the rapid discharge of a condenser across a spark gap. The transition from deflagration to much faster reaction (low velocity detonation) was found to depend on the production and collapse of cavities ahead of the reaction front. Experiments with inert liquids showed that the cavitation generated in the thin film arrange­ment was produced by a surface wave propagating on the liquid/solid interface. In other ex­periments air bubbles of chosen size were deliberately inserted into the thin films. Cavities and bubbles were observed to cause transition to fast reaction in nitroglycerine and then help sustain it by various processes, namely: (i) adiabatic collapse of cavities by pressure waves from the deflagration front; (ii) presentation, of a larger burning surface to the deflagration front as it entered the cavitated liquid, (iii) jetting during the collapse which dispersed liquid droplets in the heated cavity or produced high impact pressures. The delay before transition in nitroglycerine, and the dominant process causing it, depended on the acceleration of the deflagration front and the cavity size when the front and cavities inter­acted. Transitions did not take place in the other liquid explosives with the confinements and for the propagation distances considered. In these cases the deflagration front never accelerated sufficiently to reach cavitated liquid but always propagated into homogeneous liquid in which cavities had been ‘sealed’ by pressure waves from the front. In three-dimensional charges it was possible to propagate a deflagration front into homo­geneous liquid; the reaction then progressed throughout as a deflagration. When cavities were introduced by pre-shocking, transitions to faster reaction occurred with velocities which depended on cavity size.


2017 ◽  
Vol 95 (9) ◽  
Author(s):  
Samuel Flewett ◽  
Durgamadhab Mishra ◽  
Thiago J. A. Mori ◽  
Christian M. Günther ◽  
Juliano C. Denardin ◽  
...  

Author(s):  
Robert W. Mackin

This paper presents two advances towards the automated three-dimensional (3-D) analysis of thick and heavily-overlapped regions in cytological preparations such as cervical/vaginal smears. First, a high speed 3-D brightfield microscope has been developed, allowing the acquisition of image data at speeds approaching 30 optical slices per second. Second, algorithms have been developed to detect and segment nuclei in spite of the extremely high image variability and low contrast typical of such regions. The analysis of such regions is inherently a 3-D problem that cannot be solved reliably with conventional 2-D imaging and image analysis methods.High-Speed 3-D imaging of the specimen is accomplished by moving the specimen axially relative to the objective lens of a standard microscope (Zeiss) at a speed of 30 steps per second, where the stepsize is adjustable from 0.2 - 5μm. The specimen is mounted on a computer-controlled, piezoelectric microstage (Burleigh PZS-100, 68/μm displacement). At each step, an optical slice is acquired using a CCD camera (SONY XC-11/71 IP, Dalsa CA-D1-0256, and CA-D2-0512 have been used) connected to a 4-node array processor system based on the Intel i860 chip.


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