Destruction of Definity® Microbubbles Used for Ultrasound Imaging and Drug Delivery

2004 ◽  
Author(s):  
Kausik Sarkar ◽  
Pankaj Jain ◽  
Dhiman Chatterjee
Keyword(s):  
Drug Delivery ◽  
High Pressure ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Critical Pressure ◽  
Ultrasound Images ◽  
Medical Ultrasound ◽  
Pressure Amplitude ◽  
Single Cycle

Microbubble based contrast agents improves medical ultrasound images. Destruction of contrast agent Definity® (Bristol Meyer-Squibb Imaging, North Ballerina, MA) is studied using broadband attenuation technique. Single-cycle ultrasound pulses are sent through a bubble suspension at different pulse repetition frequencies (PRF) and pressure amplitudes. For each PRF, there is a critical pressure amplitude (~1.1–1.2MPa for 50, 100, 200 Hz PRFs studied), below which there is no evidence of bubble destruction. Above the critical pressure amplitudes the rate of destruction depends on PRF and pressure. But at high pressure amplitudes (e.g. 2.97 MPa) destruction becomes independent at higher PRFs.

Template-based formation of ultrasound microbubble contrast agents

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69185-69190 ◽  
Author(s):  
Hsiu-Ying Huang ◽  
Cheng-An J. Lin ◽  
Walter H. Chang ◽  
Chih-Kuang Yeh
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Ultrasound Images ◽  
Medical Ultrasound ◽  
Medical Ultrasound Imaging ◽  
Microbubble Contrast Agents

Precisely controlling microbubble size is critical for medical ultrasound imaging, where large microbubble contrast agents may lead to pulmonary microvascular embolization. Here we introduced a method of preparing uniform microbubbles for ultrasound images.

Amphiphilic Lipopeptide Microparticles as Contrast Agents for Medical Ultrasound Imaging

2003 ◽  
Vol 3 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Alan Cuthbertson ◽  
Audun Tornes ◽  
Magne Solbakken ◽  
Ove Moen ◽  
Morten Eriksen
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Medical Ultrasound ◽  
Medical Ultrasound Imaging

scholarly journals Effects of various De-Speckling Filters on Brachial Plexus Ultrasound Imaging

2019 ◽  
Vol 8 (2) ◽  
pp. 5058-5065
Keyword(s):  
Brachial Plexus ◽  
Ultrasound Imaging ◽  
Speckle Noise ◽  
Ultrasound Images ◽  
Medical Ultrasound ◽  
Important Process

Medical Ultrasound images are generally corrupted by Speckle noise. It deteriorates the quality of ultrasound imaging and video that makes it difficult to observe visually. Because of which resolution and contrast of the image is reduced. Despeckling of medical US images is an important process for diagnostic of disease. In this paper effect of various existing despeckling filter on ultrasound images has been studied. All the filters have been implemented in a framework and result are observed in the form of various parameters such as GAE, MSE, SNR, SRMSE, PSNR, UIQI, SSIM, AD, SC, MD. The results obtained have been used for statistically comparing the performance of the filters. It is also analyzed that which type of filters are more suited for particular type of images, noise and other conditions. This will also provide guidelines for the researchers for designing of new filters in future.

scholarly journals Echogenic exosomes as ultrasound contrast agents

2020 ◽  
Vol 2 (8) ◽  
pp. 3411-3422 ◽  
Author(s):  
Jenna Osborn ◽  
Jessica E. Pullan ◽  
James Froberg ◽  
Jacob Shreffler ◽  
Kara N. Gange ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Ultrasound Contrast Agents ◽  
Ultrasound Contrast ◽  
Potential Use

Exosomes, naturally secreted extracellular bilayer vesicles (diameter 40–130 nm), have been rendered echogenic (responsive to ultrasound) allowing their potential use as a dual agent for drug delivery and ultrasound imaging.

scholarly journals Glycosaminoglycans and Contrast Agents: The Role of Hyaluronic Acid as MRI Contrast Enhancer

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1612
Author(s):  
Alfonso Maria Ponsiglione ◽  
Maria Russo ◽  
Enza Torino
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Rational Design ◽  
Polymer Network ◽  
Molar Ratio ◽  
Titration Calorimetry ◽  
Diagnostic Systems ◽  
Mri Contrast

A comprehensive understanding of the behaviour of Glycosaminoglycans (GAGs) combined with imaging or therapeutic agents can be a key factor for the rational design of drug delivery and diagnostic systems. In this work, physical and thermodynamic phenomena arising from the complex interplay between GAGs and contrast agents for Magnetic Resonance Imaging (MRI) have been explored. Being an excellent candidate for drug delivery and diagnostic systems, Hyaluronic acid (HA) (0.1 to 0.7%w/v) has been chosen as a GAG model, and Gd-DTPA (0.01 to 0.2 mM) as a relevant MRI contrast agent. HA samples crosslinked with divinyl sulfone (DVS) have also been investigated. Water Diffusion and Isothermal Titration Calorimetry studies demonstrated that the interaction between HA and Gd-DTPA can form hydrogen bonds and coordinate water molecules, which plays a leading role in determining both the polymer conformation and the relaxometric properties of the contrast agent. This interaction can be modulated by changing the GAG/contrast agent molar ratio and by acting on the organization of the polymer network. The fine control over the combination of GAGs and imaging agents could represent an enormous advantage in formulating novel multifunctional diagnostic probes paving the way for precision nanomedicine tools.

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