scholarly journals Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery

2015 ◽  
Vol 6 ◽  
Author(s):  
Vera Paefgen ◽  
Dennis Doleschel ◽  
Fabian Kiessling
Keyword(s):  
Drug Delivery ◽  
Contrast Agents ◽  
Ultrasound Imaging

Destruction of Definity® Microbubbles Used for Ultrasound Imaging and Drug Delivery

2004 ◽  
Author(s):  
Kausik Sarkar ◽  
Pankaj Jain ◽  
Dhiman Chatterjee
Keyword(s):  
Drug Delivery ◽  
High Pressure ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Critical Pressure ◽  
Ultrasound Images ◽  
Medical Ultrasound ◽  
Pressure Amplitude ◽  
Single Cycle

Microbubble based contrast agents improves medical ultrasound images. Destruction of contrast agent Definity® (Bristol Meyer-Squibb Imaging, North Ballerina, MA) is studied using broadband attenuation technique. Single-cycle ultrasound pulses are sent through a bubble suspension at different pulse repetition frequencies (PRF) and pressure amplitudes. For each PRF, there is a critical pressure amplitude (~1.1–1.2MPa for 50, 100, 200 Hz PRFs studied), below which there is no evidence of bubble destruction. Above the critical pressure amplitudes the rate of destruction depends on PRF and pressure. But at high pressure amplitudes (e.g. 2.97 MPa) destruction becomes independent at higher PRFs.

scholarly journals Echogenic exosomes as ultrasound contrast agents

2020 ◽  
Vol 2 (8) ◽  
pp. 3411-3422 ◽  
Author(s):  
Jenna Osborn ◽  
Jessica E. Pullan ◽  
James Froberg ◽  
Jacob Shreffler ◽  
Kara N. Gange ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Ultrasound Contrast Agents ◽  
Ultrasound Contrast ◽  
Potential Use

Exosomes, naturally secreted extracellular bilayer vesicles (diameter 40–130 nm), have been rendered echogenic (responsive to ultrasound) allowing their potential use as a dual agent for drug delivery and ultrasound imaging.

Targeting and ultrasound imaging of microbubble-based contrast agents

1999 ◽  
Vol 8 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Alexander L. Klibanov ◽  
Michael S. Hughes ◽  
Flordeliza S. Villanueva ◽  
Ron J. Jankowski ◽  
William R. Wagner ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging

scholarly journals Motion Compensated Ultrasound Imaging Allows Thermometry and Image Guided Drug Delivery Monitoring from Echogenic Liposomes

Theranostics ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 1963-1974 ◽  
Author(s):  
Kalyani Ektate ◽  
Ankur Kapoor ◽  
Danny Maples ◽  
Ahmet Tuysuzoglu ◽  
Joshua VanOsdol ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ultrasound Imaging ◽  
Image Guided ◽  
Echogenic Liposomes ◽  
Image Guided Drug Delivery

Polymeric/Inorganic Multifunctional Nanoparticles for Simultaneous Drug Delivery and Visualization

2010 ◽  
Vol 1257 ◽  
Author(s):  
Andrea Fornara ◽  
Alberto Recalenda ◽  
Jian Qin ◽  
Abhilash Sugunan ◽  
Fei Ye ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Microscopy ◽  
Contrast Agents ◽  
Gold Nanorods ◽  
In Vitro Cytotoxicity ◽  
In Vivo Studies ◽  
Multifunctional Nanoparticles ◽  
Cytotoxicity Studies

AbstractNanoparticles consisting of different biocompatible materials are attracting a lot of interest in the biomedical area as useful tools for drug delivery, photo-therapy and contrast enhancement agents in MRI, fluorescence and confocal microscopy. This work mainly focuses on the synthesis of polymeric/inorganic multifunctional nanoparticles (PIMN) based on biocompatible di-block copolymer poly(L,L-lactide-co-ethylene glycol) (PLLA-PEG) via an emulsion-evaporation method. Besides containing a hydrophobic drug (Indomethacin), these polymeric nanoparticles incorporate different visualization agents such as superparamagnetic iron oxide nanoparticles (SPION) and fluorescent Quantum Dots (QDs) that are used as contrast agents for Magnetic Resonance Imaging (MRI) and fluorescence microscopy together. Gold Nanorods are also incorporated in such nanostructures to allow simultaneous visualization and photodynamic therapy. MRI studies are performed with different loading of SPION into PIMN, showing an enhancement in T2 contrast superior to commercial contrast agents. Core-shell QDs absorption and emission spectra are recorded before and after their loading into PIMN. With these polymeric/inorganic multifunctional nanoparticles, both MRI visualization and confocal fluorescence microscopy studies can be performed. Gold nanorods are also synthesized and incorporated into PIMN without changing their longitudinal absorption peak usable for lased excitation and phototherapy. In-vitro cytotoxicity studies have also been performed to confirm the low cytotoxicity of PIMN for further in-vivo studies.

scholarly journals Honey, I shrunk the bubbles: microfluidic vacuum shrinkage of lipid-stabilized microbubbles

2021 ◽  
Author(s):  
Vaskar Gnyawali ◽  
Byeong-Ui Moon ◽  
Jennifer Kieda ◽  
Raffi Karshafian ◽  
Michael C. Kolios ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Scale Up ◽  
Ultrasound Contrast Agents ◽  
Simple Approach ◽  
Vacuum Pressure ◽  
Flow Channels ◽  
Ultrasound Contrast ◽  
Microfluidic Flow ◽  
Microfluidic Technique

We present a microfluidic technique that shrinks lipidstabilized microbubbles from O(100) to O(1) µm in diameter–the size that is desirable in applications as ultrasound contrast agents. We achieve microbubble shrinkage by utilizing vacuum channels that are adjacent to the microfluidic flow channels to extract air from the microbubbles. We tune a single parameter, the vacuum pressure, to accurately control the final microbubble size. Finally, we demonstrate that the resulting O(1) µm diameter microbubbles have similar stability to microfluidics generated microbubbles that are not exposed to vacuum shrinkage. We anticipate that, with additional scale-up, this simple approach to shrink microbubbles generated microfluidically will be desirable in ultrasound imaging and therapeutics applications.

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