Nanoclay Suspension-Enabled Extrusion Bioprinting of 3D Soft Structures

2021 ◽  
pp. 1-29
Author(s):  
Yifei Jin ◽  
Ruitong Xiong ◽  
Patrick Antonelli ◽  
Christopher J. Long ◽  
Christopher W. McAleer ◽  
...  
Keyword(s):  
3D Printing ◽  
Tympanic Membrane ◽  
Solidification Rate ◽  
Three Dimensional ◽  
Glycol Diacrylate ◽  
Direct Printing ◽  
Printing System ◽  
Poly Ethylene ◽  
Extrusion Printing ◽  
3D Printing Technique

Abstract Three-dimensional (3D) extrusion printing of cellular/acellular structures with biocompatible materials has been widely investigated in recent years. However, the requirement of suitable solidification rate of printable ink materials constrains the utilization of extrusion-based 3D printing technique. In this study, the nanoclay yield-stress suspension-enabled extrusion-based 3D printing system has been investigated and demonstrated to overcome solidification rate constraints during printing. Utilizing the liquid-solid transition property of nanoclay suspension, two fabrication approaches, including nanoclay support bath-enabled printing and nanoclay-enabled direct printing, have been proposed. For the former approach, nanoclay (Laponite EP) has been used as a support bath material to fabricate alginate-based tympanic membrane patches. The constituents of alginate-based ink have been investigated to have the desired mechanical property of alginate-based tympanic membrane patches and facilitate the printing process. For the latter approach, nanoclay (Laponite XLG) has been used as an internal scaffold material to help print poly (ethylene glycol) diacrylate (PEGDA)-based neural chambers, which can be further cross-linked in air. Mechanical stress analysis has been performed to explore the geometric limitation of printable Laponite XLG-PEGDA neural chambers.

scholarly journals Novel 3D printing concept for the fabrication of time-controlled drug delivery systems

2018 ◽  
Vol 4 (1) ◽  
pp. 141-144 ◽  
Author(s):  
Jan Konasch ◽  
Alexander Riess ◽  
Michael Teske ◽  
Natalia Rekowska ◽  
Natalia Rekowska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Inkjet Printing ◽  
Drug Delivery Systems ◽  
Three Dimensional ◽  
Delivery Systems ◽  
Glycol Diacrylate ◽  
Pharmaceutical Ingredients ◽  
Poly Ethylene ◽  
Novel Concept

AbstractThree-dimensional (3D) printing has become a popular technique in many areas. One emerging field is the use of 3D printing for the development of 3D drug delivery systems (DDS) and drug-loaded medical devices. This article describes a novel concept for the fabrication of timecontrolled drug delivery systems based on stereolithography combined with inkjet printing. An inkjet printhead and an UV-LED light source have been integrated into an existing stereolithography system. Inkjet printing is used to selectively incorporate active pharmaceutical ingredients (API) during a stereolithographic 3D printing process. In an initial experimental study, poly (ethylene glycol) diacrylate (PEGDA) was used as polymer whereas 2-Hydroxy-4´-(2- hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) and Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) were used as photoinitiators. Basic structures could be manufactured successfully by the new hybrid 3D printing system.

3D Printing of Robust and Biocompatible Poly(ethylene glycol) Diacrylate/Nano-Hydroxyapatite Composites via Continuous Liquid Interface Production

2021 ◽  
Author(s):  
Xueyong Deng ◽  
Bingxue Huang ◽  
Rui Hu ◽  
Liling Chen ◽  
Yingying Tang ◽  
...  
Keyword(s):  
3D Printing ◽  
Ethylene Glycol ◽  
Three Dimensional ◽  
Liquid Interface ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
3D Printing Technology ◽  
Poly Ethylene ◽  
Continuous Liquid Interface Production ◽  
Speed And Accuracy

Three-dimensional (3D) printing technology with satisfied speed and accuracy has been a powerful force in biomaterial processing. Early studies on 3D printing of biomaterials mainly focus on their biocompatibility and...

Algorithm to Reduce Leading and Lagging in Conformal Direct-Print

2018 ◽  
Vol 140 (10) ◽  
Author(s):  
Morteza Vatani ◽  
Faez Alkadi ◽  
Jae-Won Choi
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
3D Model ◽  
Three Dimensional ◽  
Motion Direction ◽  
B Spline ◽  
And Topology ◽  
Printing System ◽  
3D Printed ◽  
Printed Patterns

A novel additive manufacturing algorithm was developed to increase the consistency of three-dimensional (3D) printed curvilinear or conformal patterns on freeform surfaces. The algorithm dynamically and locally compensates the nozzle location with respect to the pattern geometry, motion direction, and topology of the substrate to minimize lagging or leading during conformal printing. The printing algorithm was implemented in an existing 3D printing system that consists of an extrusion-based dispensing module and an XYZ-stage. A dispensing head is fixed on a Z-axis and moves vertically, while the substrate is installed on an XY-stage and moves in the x–y plane. The printing algorithm approximates the printed pattern using nonuniform rational B-spline (NURBS) curves translated directly from a 3D model. Results showed that the proposed printing algorithm increases the consistency in the width of the printed patterns. It is envisioned that the proposed algorithm can facilitate nonplanar 3D printing using common and commercially available Cartesian-type 3D printing systems.

scholarly journals Rapid and Inexpensive Fabrication of Multi-Depth Microfluidic Device using High-Resolution LCD Stereolithographic 3D Printing

2019 ◽  
Vol 3 (1) ◽  
pp. 26 ◽  
Author(s):  
Mohamed Mohamed ◽  
Hitendra Kumar ◽  
Zongjie Wang ◽  
Nicholas Martin ◽  
Barry Mills ◽  
...  
Keyword(s):  
High Resolution ◽  
3D Printing ◽  
Soft Lithography ◽  
Liquid Crystal Display ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Single Step ◽  
Droplet Generator ◽  
Rapid Fabrication ◽  
Printing System

With the dramatic increment of complexity, more microfluidic devices require 3D structures, such as multi-depth and -layer channels. The traditional multi-step photolithography is time-consuming and labor-intensive and also requires precise alignment during the fabrication of microfluidic devices. Here, we present an inexpensive, single-step, and rapid fabrication method for multi-depth microfluidic devices using a high-resolution liquid crystal display (LCD) stereolithographic (SLA) three-dimensional (3D) printing system. With the pixel size down to 47.25 μm, the feature resolutions in the horizontal and vertical directions are 150 μm and 50 μm, respectively. The multi-depth molds were successfully printed at the same time and the multi-depth features were transferred properly to the polydimethylsiloxane (PDMS) having multi-depth channels via soft lithography. A flow-focusing droplet generator with a multi-depth channel was fabricated using the presented 3D printing method. Experimental results show that the multi-depth channel could manipulate the morphology and size of droplets, which is desired for many engineering applications. Taken together, LCD SLA 3D printing is an excellent alternative method to the multi-step photolithography for the fabrication of multi-depth microfluidic devices. Taking the advantages of its controllability, cost-effectiveness, and acceptable resolution, LCD SLA 3D printing can have a great potential to fabricate 3D microfluidic devices.

scholarly journals Three-Dimensional Laser Printing of Macro-Scale Glass Objects at a Micro-Scale Resolution

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 565 ◽  
Author(s):  
Peng Wang ◽  
Wei Chu ◽  
Wenbo Li ◽  
Yuanxin Tan ◽  
Fang Liu ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Laser Pulses ◽  
Fused Silica ◽  
Rapid Expansion ◽  
Ultrafast Laser Pulses ◽  
3D Objects ◽  
Macro Scale ◽  
Powerful Approach ◽  
3D Printing Technique

Three-dimensional (3D) printing has allowed for the production of geometrically complex 3D objects with extreme flexibility, which is currently undergoing rapid expansion in terms of materials, functionalities, as well as areas of application. When attempting to print 3D microstructures in glass, femtosecond laser-induced chemical etching (FLICE)—which is a subtractive 3D printing technique—has proved itself a powerful approach. Here, we demonstrate the fabrication of macro-scale 3D glass objects of large heights up to ~3.8 cm with an identical lateral and longitudinal feature size of ~20 μm. The remarkable accomplishment is achieved by revealing an unexplored regime in the interaction of ultrafast laser pulses with fused silica, which results in depth-insensitive focusing of the laser pulses inside fused silica.

Comparison of Supermacroporous Polyester Matrices Fabricated by Thermally Induced Phase Separation and 3D Printing Techniques

2019 ◽  
Vol 822 ◽  
pp. 277-283
Author(s):  
Mariia Stepanova ◽  
Aleksei Eremin ◽  
Ilia Averianov ◽  
Iosif Gofman ◽  
Antonina Lavrentieva ◽  
...  
Keyword(s):  
Phase Separation ◽  
3D Printing ◽  
Three Dimensional ◽  
Uniaxial Compression Test ◽  
Thermally Induced Phase Separation ◽  
Cell Penetration ◽  
Thermally Induced ◽  
Printing Technique ◽  
3D Printing Technique ◽  
Printing Techniques

Supermacroporous three-dimensional matrices based on poly-D,L-lactide or polycaprolactone were fabricated by thermally induced phase separation method and 3D printing technique. The morphology and mechanical properties of the resulting matrices were studied with the use of optical and scanning electron microscopy and the uniaxial compression test, respectively. All matrices were characterized with supermacroporous structure suitable for cell penetration. A significant increase in Young's modulus and tensile strength was established for both polymer matrices prepared by 3D printing technique.

scholarly journals Three-Dimensional Laser Printing of Macro-Scale Glass Objects at a Micro-Scale Resolution

2019 ◽  
Author(s):  
Peng Wang ◽  
Wei Chu ◽  
Wenbo Li ◽  
Yuanxin Tan ◽  
Fang Liu ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Laser Pulses ◽  
Fused Silica ◽  
Ultrafast Laser Pulses ◽  
3D Objects ◽  
Macro Scale ◽  
Powerful Approach ◽  
Printing Technique ◽  
3D Printing Technique

Three-dimensional (3D) printing has allowed for production of geometrically complex 3D objects with extreme flexibility, which is currently undergoing rapid expansions in terms of materials, functionalities, as well as areas of application. When attempting to print 3D microstructures in glass, femtosecond laser induced chemical etching (FLICE) – which is a subtractive 3D printing technique – has proved itself a powerful approach. Here, we demonstrate fabrication of macro-scale 3D glass objects of large heights up to ~3.8 cm with an identical lateral and longitudinal spatial resolution of ~20 μm. The remarkable accomplishment is achieved by revealing an unexplored regime in the interaction of ultrafast laser pulses with fused silica which results in aberration-free focusing of the laser pulses deeply inside fused silica.

scholarly journals Fabrication 3d Tissue Engineering Scaffold Poly(Ethylene) Diacrylate Filled with Aramid Nanofiber: Mechanical Evaluation and Toxicity

2019 ◽  
Vol 8 (12) ◽  
pp. 1997-2006
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
3D Structure ◽  
Tissue Engineering Scaffold ◽  
Digital Light Processing ◽  
Technical Requirements ◽  
Preliminary Study ◽  
Poly Ethylene ◽  
3D Printing Technique ◽  
Selection Of

The selection of the optimum scaffold fabrication method becomes challenging due to a variety of manufacturing methods, existing biomaterials and technical requirements. Although, Digital light processing (DLP) 3D printing process is one of the SLA techniques which commonly used to fabricate tissue engineering scaffold, however, there is no report published on the fabrication of tissue engineering scaffold-based PEGDA filled with Aramid Nanofiber (ANFs). Hence, the feasible parameter setting for fabricating this material using DLP technique is currently unknown. This work aims to establish the feasible setting parameter via DLP 3D printing to fabricate PEGDA/ANFs 3D tissue engineering scaffold. Preliminary study has been done to identify the accurate composition and curing time setting in producing scaffold. In this work, the researcher has proved the potential and capability of these novel composition biomaterial PEGDA/ANFs to be print via DLP-3D printing technique to form a 3D structure which is not yet been established and has not reported elsewhere.

scholarly journals Therapeutic effect of acetabular fractures using the Pararectus approach combined with 3D printing technique

2020 ◽  
Author(s):  
Ruyi Zou ◽  
Min Wu ◽  
Jianzhong Guan ◽  
Yuzhou Xiao ◽  
Xiaotian Chen
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Operation Time ◽  
Acetabular Fractures ◽  
Effective Reduction ◽  
Printing Technique ◽  
Dimensional Reconstruction ◽  
Hip Function ◽  
Pararectus Approach ◽  
3D Printing Technique

Abstract Background To explore the clinical efficacy of pararectus approach combined with 3D printing technique for the surgical treatment of partial complex acetabular fractures. Methods We retrospectively evaluated 18 (11 males and 7 females) patients with complicated acetabular fractures in the period of June 2017 to December 2018; According to judet-letenneal classification: 11 cases were of double column fracture, 6 fractures were of the anterior column with posterior half transverse, and 1 case was of "T" fracture. For all cases, 3D printing is used to print the acetabular model. Pre-bent reconstruction plates from the model were placed to fixate fractures after reduction via the pararectus approach. Results The average time of surgery was 203 min (range:135-245 min)and mean intraoperative blood loss was 1030ml(range:450-1400ml);18 patients were followed up for 12-18 months (average,14 months);One patient (5.6%) developed postoperative wound infection, and the wound completely improved by secretion culture, enhanced dressing and effective antibiotics. One patient (5.6%) developed postoperative ossifying myositis, and there are no obvious symptoms at present; all patients underwent pelvic films and pelvic CT+ three-dimensional reconstruction after surgery, suggesting that fractures reduction as well. All the acetabular fractures united after 12 to 16 weeks(average,13 weeks);According to the modified Merle d’Aubigne and Postel scoring system to assess the hip function: excellent in 13 cases (72.2%), good in 3 cases(16.7%) and fair in 2 cases(11.1%). Conclusions In the treatment of partial complex acetabular fractures, the pararectus approach combined with 3D printing technique can achieve effective reduction and fixation, decrease intraoperative hemorrhage, shorten operation time and the internal fixation position can be properly adjusted during the operation by looking directly at the model.

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