3D Printing of Robust and Biocompatible Poly(ethylene glycol) Diacrylate/Nano-Hydroxyapatite Composites via Continuous Liquid Interface Production

2021 ◽  
Author(s):  
Xueyong Deng ◽  
Bingxue Huang ◽  
Rui Hu ◽  
Liling Chen ◽  
Yingying Tang ◽  
...  
Keyword(s):  
3D Printing ◽  
Ethylene Glycol ◽  
Three Dimensional ◽  
Liquid Interface ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
3D Printing Technology ◽  
Poly Ethylene ◽  
Continuous Liquid Interface Production ◽  
Speed And Accuracy

Three-dimensional (3D) printing technology with satisfied speed and accuracy has been a powerful force in biomaterial processing. Early studies on 3D printing of biomaterials mainly focus on their biocompatibility and...

Culturing of transgenic mice liver tissue slices in three-dimensional microfluidic structures of PEG-DA (poly(ethylene glycol) diacrylate)

2013 ◽  
Vol 176 ◽  
pp. 1081-1089 ◽  
Author(s):  
Shilpa Sivashankar ◽  
Srinivasu Valegerahally Puttaswamy ◽  
Ling-Hui Lin ◽  
Tz-Shuian Dai ◽  
Chau-Ting Yeh ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Ethylene Glycol ◽  
Liver Tissue ◽  
Three Dimensional ◽  
Poly Ethylene Glycol ◽  
Tissue Slices ◽  
Glycol Diacrylate ◽  
Poly Ethylene ◽  
Mice Liver

scholarly journals Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 833 ◽  
Author(s):  
Mirjana Krkobabić ◽  
Djordje Medarević ◽  
Nikola Pešić ◽  
Dragana Vasiljević ◽  
Branka Ivković ◽  
...  
Keyword(s):  
3D Printing ◽  
Ethylene Glycol ◽  
Polarized Light ◽  
Layer By Layer ◽  
Poly Ethylene Glycol ◽  
Sustained Drug Release ◽  
Digital Light Processing ◽  
Printing Process ◽  
Glycol Diacrylate ◽  
Poly Ethylene

Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets of atomoxetine hydrochloride (ATH) have been successfully fabricated by a digital light processing (DLP) 3D printing technology. Initial materials were photoreactive suspensions, composed of poly(ethylene glycol) diacrylate 700 (PEGDA 700), poly(ethylene glycol) 400 (PEG 400), photoinitiator and suspended ATH. The amount of ATH was varied from 10.00 to 25.00% (w/w), and a range of doses from 12.21 to 40.07 mg has been achieved, indicating the possibility of personalized therapy. The rheological characteristics of all photoreactive suspensions were appropriate for the printing process, while the amount of the suspended particles in the photoreactive suspensions had an impact on the 3D printing process, as well as on mechanical and biopharmaceutical characteristics of tablets. Only the formulation with the highest content of ATH had significantly different tensile strength compared to other formulations. All tablets showed sustained drug release during at least the 8h. ATH crystals were observed with polarized light microscopy of photoreactive suspensions and the cross-sections of the tablets, while no interactions between ATH and polymers were detected by FT-IR spectroscopy.

scholarly journals Extrusion-Based 3D Printing of Poly(ethylene glycol) Diacrylate Hydrogels Containing Positively and Negatively Charged Groups

Gels ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 69 ◽  
Author(s):  
Sebastian Joas ◽  
Günter Tovar ◽  
Oguz Celik ◽  
Christian Bonten ◽  
Alexander Southan
Keyword(s):  
3D Printing ◽  
Ethylene Glycol ◽  
Poloxamer 407 ◽  
Careful Examination ◽  
Flow Profile ◽  
Trimethylammonium Chloride ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Material Deposition ◽  
Poly Ethylene

Hydrogels are an interesting class of materials used in extrusion-based 3D printing, e.g., for drug delivery or tissue engineering. However, new hydrogel formulations for 3D printing as well as a detailed understanding of crucial formulation properties for 3D printing are needed. In this contribution, hydrogels based on poly(ethylene glycol) diacrylate (PEG-DA) and the charged monomers 3-sulfopropyl acrylate and [2-(acryloyloxy)ethyl]trimethylammonium chloride are formulated for 3D printing, together with Poloxamer 407 (P407). Chemical curing of formulations with PEG-DA and up to 5% (w/w) of the charged monomers was possible without difficulty. Through careful examination of the rheological properties of the non-cured formulations, it was found that flow properties of formulations with a high P407 concentration of 22.5% (w/w) possessed yield stresses well above 100 Pa together with pronounced shear thinning behavior. Thus, those formulations could be processed by 3D printing, as demonstrated by the generation of pyramidal objects. Modelling of the flow profile during 3D printing suggests that a plug-like laminar flow is prevalent inside the printer capillary. Under such circumstances, fast recovery of a high vicosity after material deposition might not be necessary to guarantee shape fidelity because the majority of the 3D printed volume does not face any relevant shear stress during printing.

Micropatterning of Poly (Ethylene Glycol)-Diacrylate (PEG-DA) Hydrogel by Soft-Photolithography for Analysis of Cell-Biomaterial Interactions

2009 ◽  
Vol 2 ◽  
pp. 3-14 ◽  
Author(s):  
Karthikeyan Subramani ◽  
M.A. Birch
Keyword(s):  
Ethylene Glycol ◽  
Three Dimensional ◽  
Poly Ethylene Glycol ◽  
Contact Printing ◽  
Pdms Stamp ◽  
Glycol Diacrylate ◽  
Dimethyl Siloxane ◽  
Hydrogel Matrix ◽  
Poly Ethylene ◽  
Innovative Techniques

Poly (ethylene glycol) hydrogel (PEG) micropatterns fabricated by photolithography and various other microfabrication techniques have been used as a platform to analyze cell-biomaterial interactions in cell culture studies. Numerous innovative techniques have been described about photolithography and the use of Poly (dimethyl siloxane) stamp (PDMS) based pressure moulding technique for the microfabrication of PEG hydrogel micropatterns. We herein this literature describe a simple and a versatile method for fabricating Poly (ethylene glycol) hydrogel-diacrylate (PEG-DA) hydrogel micropatterns using the ‘Soft-photolithography’ technique which is a combination of pressure moulding using a PDMS stamp and photolithography. Using this simple technique, PEG-DA hydrogel micropatterns were fabricated on a silicon substrate of varying dimensions from 40μm to 10μm within the same substrate. Such a three-dimensional microenvironment with varying sizes can serve as an excellent platform to study cell behaviour in culture. These PEG-DA hydrogel micropatterns can further be functionalized by adding a variety of biomolecular cues within the PEG-DA hydrogel matrix or these biomolecules can be patterned on the PEG-DA micropatterns after photopolymerization using micro-contact printing for analysis of cell-biomaterial interactions and tissue engineering purposes.

scholarly journals Gel Polymer Electrolytes Based on Cross-Linked Poly(ethylene glycol) Diacrylate for Calcium-Ion Conduction

ACS Omega ◽  
2021 ◽  
Author(s):  
Saeid Biria ◽  
Shreyas Pathreeker ◽  
Francielli S. Genier ◽  
Fu-Hao Chen ◽  
Hansheng Li ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Polymer Electrolytes ◽  
Calcium Ion ◽  
Gel Polymer Electrolytes ◽  
Poly Ethylene Glycol ◽  
Ion Conduction ◽  
Glycol Diacrylate ◽  
Poly Ethylene
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