Personalized Design of Functional Gradient Bone Tissue Engineering Scaffold

2019 ◽  
Vol 141 (11) ◽  
Author(s):  
Wei Chen ◽  
Ning Dai ◽  
Jinqiang Wang ◽  
Hao Liu ◽  
Dawei Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Structural Characteristics ◽  
Optimization Method ◽  
Biomechanical Properties ◽  
Parametric Modeling ◽  
Pore Distribution ◽  
Element Analysis ◽  
Natural Bone

The porous structure of the natural bone not only has the characteristics of lightweight and high strength but also is conducive to the growth of cells and tissues due to interconnected pores. In this paper, a novel gradient-controlled parametric modeling technology is presented to design bone tissue engineering (BTE) scaffold. First of all, the method functionalizes the pore distribution in the bone tissue, and reconstructs the pore distribution of the bone tissue in combination with the pathological analysis of the bone defect area of the individual patient. Then, based on the reconstructed pore distribution, the Voronoi segmentation algorithm and the contour interface optimization method are used to reconstruct the whole model of the bone tissue. Finally, the mechanical properties of the scaffold are studied by the finite element analysis of different density gradient scaffolds. The results show that the method is highly feasible. BTE scaffold can be designed by irregular design methods and adjustment of pore distribution parameters, which is similar with natural bone in structural characteristics and biomechanical properties

scholarly journals Design and Mechanical Properties Verification of Gradient Voronoi Scaffold for Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 664
Author(s):  
Haiyuan Zhao ◽  
Yafeng Han ◽  
Chen Pan ◽  
Ding Yang ◽  
Haotian Wang ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Tissue Engineering ◽  
Elastic Modulus ◽  
Porous Structure ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Voronoi Tessellation ◽  
Impact Resistance ◽  
Natural Bone ◽  
The Impact

In order to obtain scaffold that can meet the therapeutic effect, researchers have carried out research on irregular porous structures. However, there are deficiencies in the design method of accurately controlling the apparent elastic modulus of the structure at present. Natural bone has a gradient porous structure. However, there are few studies on the mechanical property advantages of gradient bionic bone scaffold. In this paper, an improved method based on Voronoi-tessellation is proposed. The method can get controllable gradient scaffolds to fit the modulus of natural bone, and accurately control the apparent elastic modulus of porous structure, which is conducive to improving the stress shielding. To verify the designed structure can be fabricated by additive manufacturing, several designed models are obtained by SLM and EBM. Through finite element analysis (FEA), it is verified that the irregular porous structure based on Voronoi-tessellation is more stable than the traditional regular porous structure of the same structure volume, the same pore number and the same material. Furthermore, it is verified that the gradient irregular structure has a better stability than the non-gradient structure. An experiment is conducted successfully to verify the stability performance got by FEA. In addition, a dynamic impact FEA is also performed to simulate impact resistance. The result shows that the impact resistance of the regular porous structure, the irregular porous structure and the gradient irregular porous structure becomes better in turn. The mechanical property verification provides a theoretical basis for the structural design of gradient irregular porous bone tissue engineering scaffolds.

scholarly journals Synthesis, characterization and osteogenesis of phosphorylated methacrylamide chitosan hydrogels

RSC Advances ◽  
2018 ◽  
Vol 8 (63) ◽  
pp. 36331-36337 ◽  
Author(s):  
Huishang Yang ◽  
Shenggui Chen ◽  
Lei Liu ◽  
Chen Lai ◽  
Xuetao Shi
Keyword(s):  
Tissue Engineering ◽  
Bone Formation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Natural Bone ◽  
Chitosan Hydrogels

Phosphorylated biopolymers can induce mineralization, mimic the process of natural bone formation, and have the potential as scaffolds for bone tissue engineering.

scholarly journals Carbon Nanostructures in Bone Tissue Engineering

2016 ◽  
Vol 10 (1) ◽  
pp. 877-899 ◽  
Author(s):  
Brian Lee Perkins ◽  
Naghmeh Naderi
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Carbon Nanostructures ◽  
Bone Tissue Regeneration ◽  
Biophysical Properties ◽  
Carbon Nanostructure ◽  
Natural Bone ◽  
Wide Range

Background:Recent advances in developing biocompatible materials for treating bone loss or defects have dramatically changed clinicians’ reconstructive armory. Current clinically available reconstructive options have certain advantages, but also several drawbacks that prevent them from gaining universal acceptance. A wide range of synthetic and natural biomaterials is being used to develop tissue-engineered bone. Many of these materials are currently in the clinical trial stage.Methods:A selective literature review was performed for carbon nanostructure composites in bone tissue engineering.Results:Incorporation of carbon nanostructures significantly improves the mechanical properties of various biomaterials to mimic that of natural bone. Recently, carbon-modified biomaterials for bone tissue engineering have been extensively investigated to potentially revolutionize biomaterials for bone regeneration.Conclusion:This review summarizes the chemical and biophysical properties of carbon nanostructures and discusses their functionality in bone tissue regeneration.

scholarly journals Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering

2021 ◽  
Vol 8 ◽  
Author(s):  
Xinming Gu ◽  
Xiaolin Sun ◽  
Yue Sun ◽  
Jia Wang ◽  
Yiping Liu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Elastic Modulus ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Clinical Applications ◽  
Structure And Function ◽  
Natural Bone ◽  
The Future ◽  
And Function ◽  
Surrounding Bone

In recent years, polyetheretherketone (PEEK) has been increasingly employed as an implant material in clinical applications. Although PEEK is biocompatible, chemically stable, and radiolucent and has an elastic modulus similar to that of natural bone, it suffers from poor integration with surrounding bone tissue after implantation. To improve the bioactivity of PEEK, numerous strategies for functionalizing the PEEK surface and changing the PEEK structure have been proposed. Inspired by the components, structure, and function of bone tissue, this review discusses strategies to enhance the biocompatibility of PEEK implants and provides direction for fabricating multifunctional implants in the future.

MicroCT Aided Scaffold Design and Preparation

2007 ◽  
Vol 336-338 ◽  
pp. 1584-1586
Author(s):  
Xian Gang Wang ◽  
Jie Mo Tian ◽  
Zhi Ping Guo ◽  
Chao Zong Zhang ◽  
Chen Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Repair ◽  
Three Dimensional ◽  
Rapid Prototype ◽  
Regeneration Ability ◽  
Natural Bone ◽  
Bone Trauma ◽  
Aided Design

Bone repair method has run to a new stage of bone tissue engineering. Doctors use bone scaffold to fill bone trauma and expect human regeneration ability to reconstruct bone trauma while bone is degrading. Scaffold is essential to bone tissue engineering. Scaffold should introduce new bone with scaffold’s conduction channel. But it’s still very difficult for scaffold to mimic fine structure of bone. Ideal scaffold should have similar component and microstructure to natural bone, which makes it more biocompatible and better to reconstructed bone. So we forward microCT aided design and preparation to solve this problem. MicroCT outputs both shape and three-dimensional internal density information. Then, we build computer model of scaffold with acquired microstructure. We fabricate scaffold that mimics natural bone by 3D rapid prototype machine.

scholarly journals Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide

2017 ◽  
Vol 455 ◽  
pp. 90-97 ◽  
Author(s):  
Anahí Philippart ◽  
Natividad Gómez-Cerezo ◽  
Daniel Arcos ◽  
Antonio J. Salinas ◽  
Elena Boccardi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Structural Characteristics ◽  
Engineering Study

scholarly journals An update on the Application of Nanotechnology in Bone Tissue Engineering

2016 ◽  
Vol 10 (1) ◽  
pp. 836-848 ◽  
Author(s):  
MF Griffin ◽  
DM Kalaskar ◽  
A. Seifalian ◽  
PE Butler
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Structure ◽  
Bioactive Molecules ◽  
Bone Tissue Regeneration ◽  
Native Bone ◽  
Natural Bone ◽  
Nanofibrous Scaffolds

Background:Natural bone is a complex and hierarchical structure. Bone possesses an extracellular matrix that has a precise nano-sized environment to encourage osteoblasts to lay down bone by directing them through physical and chemical cues. For bone tissue regeneration, it is crucial for the scaffolds to mimic the native bone structure. Nanomaterials, with features on the nanoscale have shown the ability to provide the appropriate matrix environment to guide cell adhesion, migration and differentiation.Methods:This review summarises the new developments in bone tissue engineering using nanobiomaterials. The design and selection of fabrication methods and biomaterial types for bone tissue engineering will be reviewed. The interactions of cells with different nanostructured scaffolds will be discussed including nanocomposites, nanofibres and nanoparticles.Results:Several composite nanomaterials have been able to mimic the architecture of natural bone. Bioceramics biomaterials have shown to be very useful biomaterials for bone tissue engineering as they have osteoconductive and osteoinductive properties. Nanofibrous scaffolds have the ability to provide the appropriate matrix environment as they can mimic the extracellular matrix structure of bone. Nanoparticles have been used to deliver bioactive molecules and label and track stem cells.Conclusion:Future studies to improve the application of nanomaterials for bone tissue engineering are needed.

scholarly journals A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

Membranes ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 62 ◽  
Author(s):  
Deval Bhattarai ◽  
Ludwig Aguilar ◽  
Chan Park ◽  
Cheol Kim
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biological Activities ◽  
Biomechanical Properties ◽  
Electrospun Fibers ◽  
Fibrous Materials ◽  
Interdisciplinary Field ◽  
Versatile Technique ◽  
Differentiation And Proliferation

Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.

scholarly journals Bioactive Glasses in Bone Tissue Engineering/ Bioaktivna stakla u inženjerstvu koštanih tkiva

2015 ◽  
Vol 62 (2) ◽  
pp. 71-79
Author(s):  
Vukoman Jokanović ◽  
Božana Čolović ◽  
Dejan Marković ◽  
Slavoljub Živković
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Scientific Community ◽  
Structural Characteristics ◽  
Bioactive Glasses ◽  
Bioactive Substances ◽  
Implant Coating ◽  
Synthesized Materials ◽  
Positive Effect

SUMMARY Bioactive glasses are often used nanomaterials in tissue engineering of bone and soft tissue. Many newly synthesized materials for applications in medicine and dentistry are based on these bioactive substances. Bioactive glass is usually used as a scaffold or as an implant coating on implants and it allows fast formation of apatite layer with positive effect on osteoblasts proliferation. These biomaterials play an important role in dentistry and endodontics. This study is mostly part of the monograph titled “Nanomedicine, the Greatest Challenge of the 21st Century”, that for two years has received attention from professional and scientific community in various fields. Information presented in this paper highlight structural characteristics of bioactive glasses that have a significant role in bone tissue engineering

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