scholarly journals Design and Mechanical Properties Verification of Gradient Voronoi Scaffold for Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 664
Author(s):  
Haiyuan Zhao ◽  
Yafeng Han ◽  
Chen Pan ◽  
Ding Yang ◽  
Haotian Wang ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Tissue Engineering ◽  
Elastic Modulus ◽  
Porous Structure ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Voronoi Tessellation ◽  
Impact Resistance ◽  
Natural Bone ◽  
The Impact

In order to obtain scaffold that can meet the therapeutic effect, researchers have carried out research on irregular porous structures. However, there are deficiencies in the design method of accurately controlling the apparent elastic modulus of the structure at present. Natural bone has a gradient porous structure. However, there are few studies on the mechanical property advantages of gradient bionic bone scaffold. In this paper, an improved method based on Voronoi-tessellation is proposed. The method can get controllable gradient scaffolds to fit the modulus of natural bone, and accurately control the apparent elastic modulus of porous structure, which is conducive to improving the stress shielding. To verify the designed structure can be fabricated by additive manufacturing, several designed models are obtained by SLM and EBM. Through finite element analysis (FEA), it is verified that the irregular porous structure based on Voronoi-tessellation is more stable than the traditional regular porous structure of the same structure volume, the same pore number and the same material. Furthermore, it is verified that the gradient irregular structure has a better stability than the non-gradient structure. An experiment is conducted successfully to verify the stability performance got by FEA. In addition, a dynamic impact FEA is also performed to simulate impact resistance. The result shows that the impact resistance of the regular porous structure, the irregular porous structure and the gradient irregular porous structure becomes better in turn. The mechanical property verification provides a theoretical basis for the structural design of gradient irregular porous bone tissue engineering scaffolds.

scholarly journals Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering

2021 ◽  
Vol 8 ◽  
Author(s):  
Xinming Gu ◽  
Xiaolin Sun ◽  
Yue Sun ◽  
Jia Wang ◽  
Yiping Liu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Elastic Modulus ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Clinical Applications ◽  
Structure And Function ◽  
Natural Bone ◽  
The Future ◽  
And Function ◽  
Surrounding Bone

In recent years, polyetheretherketone (PEEK) has been increasingly employed as an implant material in clinical applications. Although PEEK is biocompatible, chemically stable, and radiolucent and has an elastic modulus similar to that of natural bone, it suffers from poor integration with surrounding bone tissue after implantation. To improve the bioactivity of PEEK, numerous strategies for functionalizing the PEEK surface and changing the PEEK structure have been proposed. Inspired by the components, structure, and function of bone tissue, this review discusses strategies to enhance the biocompatibility of PEEK implants and provides direction for fabricating multifunctional implants in the future.

scholarly journals Environmental Impact for 3D Bone Tissue Engineering Scaffolds Life Cycle: An Assessment

2021 ◽  
Vol 12 (5) ◽  
pp. 6504-6515
Keyword(s):  
Tissue Engineering ◽  
Life Cycle Assessment ◽  
Life Cycle ◽  
Environmental Impact ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Environmental Impacts ◽  
Tissue Engineering Scaffolds ◽  
Industrial Soil ◽  
The Impact

With the development of additive manufacturing technology, 3D bone tissue engineering scaffolds have evolved. Bone tissue engineering is one of the techniques for repairing bone abnormalities caused by a variety of circumstances, such as injuries or the need to support damaged sections. Many bits of research have gone towards developing 3D bone tissue engineering scaffolds all across the world. The assessment of the environmental impact, on the other hand, has received less attention. As a result, the focus of this study is on developing a life cycle assessment (LCA) model for 3D bone tissue engineering scaffolds and evaluating potential environmental impacts. One of the methodologies to evaluating a complete environmental impact assessment is life cycle assessment (LCA). The cradle-to-grave method will be used in this study, and GaBi software was used to create the analysis for this study. Previous research on 3D bone tissue engineering fabrication employing poly(ethylene glycol) diacrylate (PEGDA) soaked in dimethyl sulfoxide (DMSO), and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (TPO) as a photoinitiator will be reviewed. Meanwhile, digital light processing (DLP) 3D printing is employed as the production technique. The GaBi program and the LCA model developed to highlight the potential environmental impact. This study shows how the input and output of LCA of 3D bone tissue engineering scaffolds might contribute to environmental issues such as air, freshwater, saltwater, and industrial soil emissions. The emission contributing to potential environmental impacts comes from life cycle input, electricity and transportation consumption, manufacturing process, and material resources. The results from this research can be used as an indicator for the researcher to take the impact of the development of 3D bone tissue engineering on the environment seriously.

Personalized Design of Functional Gradient Bone Tissue Engineering Scaffold

2019 ◽  
Vol 141 (11) ◽  
Author(s):  
Wei Chen ◽  
Ning Dai ◽  
Jinqiang Wang ◽  
Hao Liu ◽  
Dawei Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Structural Characteristics ◽  
Optimization Method ◽  
Biomechanical Properties ◽  
Parametric Modeling ◽  
Pore Distribution ◽  
Element Analysis ◽  
Natural Bone

The porous structure of the natural bone not only has the characteristics of lightweight and high strength but also is conducive to the growth of cells and tissues due to interconnected pores. In this paper, a novel gradient-controlled parametric modeling technology is presented to design bone tissue engineering (BTE) scaffold. First of all, the method functionalizes the pore distribution in the bone tissue, and reconstructs the pore distribution of the bone tissue in combination with the pathological analysis of the bone defect area of the individual patient. Then, based on the reconstructed pore distribution, the Voronoi segmentation algorithm and the contour interface optimization method are used to reconstruct the whole model of the bone tissue. Finally, the mechanical properties of the scaffold are studied by the finite element analysis of different density gradient scaffolds. The results show that the method is highly feasible. BTE scaffold can be designed by irregular design methods and adjustment of pore distribution parameters, which is similar with natural bone in structural characteristics and biomechanical properties

scholarly journals Synthesis, characterization and osteogenesis of phosphorylated methacrylamide chitosan hydrogels

RSC Advances ◽  
2018 ◽  
Vol 8 (63) ◽  
pp. 36331-36337 ◽  
Author(s):  
Huishang Yang ◽  
Shenggui Chen ◽  
Lei Liu ◽  
Chen Lai ◽  
Xuetao Shi
Keyword(s):  
Tissue Engineering ◽  
Bone Formation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Natural Bone ◽  
Chitosan Hydrogels

Phosphorylated biopolymers can induce mineralization, mimic the process of natural bone formation, and have the potential as scaffolds for bone tissue engineering.

Novel hydroxyethyl chitosan/cellulose scaffolds with bubble-like porous structure for bone tissue engineering

2017 ◽  
Vol 167 ◽  
pp. 44-51 ◽  
Author(s):  
Yaping Wang ◽  
Junmin Qian ◽  
Na Zhao ◽  
Ting Liu ◽  
Weijun Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Porous Structure ◽  
Bone Tissue Engineering ◽  
Bone Tissue

scholarly journals Carbon Nanostructures in Bone Tissue Engineering

2016 ◽  
Vol 10 (1) ◽  
pp. 877-899 ◽  
Author(s):  
Brian Lee Perkins ◽  
Naghmeh Naderi
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Carbon Nanostructures ◽  
Bone Tissue Regeneration ◽  
Biophysical Properties ◽  
Carbon Nanostructure ◽  
Natural Bone ◽  
Wide Range

Background:Recent advances in developing biocompatible materials for treating bone loss or defects have dramatically changed clinicians’ reconstructive armory. Current clinically available reconstructive options have certain advantages, but also several drawbacks that prevent them from gaining universal acceptance. A wide range of synthetic and natural biomaterials is being used to develop tissue-engineered bone. Many of these materials are currently in the clinical trial stage.Methods:A selective literature review was performed for carbon nanostructure composites in bone tissue engineering.Results:Incorporation of carbon nanostructures significantly improves the mechanical properties of various biomaterials to mimic that of natural bone. Recently, carbon-modified biomaterials for bone tissue engineering have been extensively investigated to potentially revolutionize biomaterials for bone regeneration.Conclusion:This review summarizes the chemical and biophysical properties of carbon nanostructures and discusses their functionality in bone tissue regeneration.

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