Study of Liquid-Metal Based Heating Method for Temperature Gradient Focusing Purpose

2013 ◽  
Vol 135 (9) ◽  
Author(s):  
M. Gao ◽  
L. Gui ◽  
J. Liu

Temperature gradient focusing (TGF) is a highly efficient focusing technique for the concentration and separation of charged analytes in microfluidic channels. The design of an appropriate temperature gradient is very important for the focusing efficiency. In this study, we proposed a new technique to generate the temperature gradient. This technique utilizes a microchannel filled with liquid-metal as an electrical heater in a microfluidic chip. By applying an electric current, the liquid-metal heater generates Joule heat, forming the temperature gradient in the microchannel. To optimize the temperature gradient and find out the optimal design for the TGF chip, numerical simulations on four typical designs were studied. The results showed that design 1 can provide a best focusing method, which has the largest temperature gradient. For this best design, the temperature is almost linearly distributed along the focusing microchannel. The numerical simulations were then validated both theoretically and experimentally. The following experiment and theoretical analysis on the best design also provide a useful guidance for designing and fabricating the liquid-metal based TGF microchip.

Author(s):  
Meng Gao ◽  
Lin Gui ◽  
Jing Liu

Temperature gradient focusing (TGF) is a highly efficient focusing technique for the concentration and separation of charged analytes in microfluidic channels. Design and control of an appropriate temperature gradient are very important for protein concentration and separation. In this study, we propose a new technique to generate the temperature gradient for the focusing purpose. This technique utilizes a microchannel filled with liquid-metals as a heater in the microfluidic chip. By applying electrical current, the liquid-metal microchannel generates Joule heat to form temperature gradient in the microfluidic chip. To optimize the temperature gradient, several typical designs were investigated. The results show the best design which provides the largest linear temperature gradient. The parametric studies present a clear guideline for designing aTGF microfluidic chip.


2015 ◽  
Vol 9 (1) ◽  
pp. 618-623 ◽  
Author(s):  
Zhu Yili ◽  
Zhang Yongchun

In an active magnetic bearing (AMB) system, the catcher bearings (CBs) are essential to protect the system in cases of AMB failure. On the basis of the former researches of double-decker catcher bearings (DDCBs), a tolerance ring is proposed to further improve the performance of DDCB. Firstly, the support model of DDCB supported by tolerance ring is established. Then numerical simulations are carried out to determine the design parameters of tolerance ring. Finally, the tolerance ring is manufactured according to the obtained parameters and relative experiments are carried out to verify the theoretical analysis results. Both theoretical and experimental results validated that proper tolerance ring is beneficial to reduce the following impact forces and vibrations after rotor drop.


2015 ◽  
Vol 46 (5) ◽  
pp. 439-464
Author(s):  
Nikolay Alekseevich Zlenko ◽  
Innokentii Aleksandrovich Kursakov

2021 ◽  
Vol 11 (4) ◽  
pp. 1960
Author(s):  
Naming Zhang ◽  
Ziang Wang ◽  
Jinhua Shi ◽  
Shuya Ning ◽  
Yukuo Zhang ◽  
...  

Previous research showed that pulsed functional magnetic stimulation can activate brain tissue with optimum intensity and frequency. Conventional stimulation coils are always set as a figure-8 type or Helmholtz. However, the magnetic fields generated by these coils are uniform around the target, and their magnetic stimulation performance still needs improvement. In this paper, a novel type of stimulation coil is proposed to shrink the irritative zone and strengthen the stimulation intensity. Furthermore, the electromagnetic field distribution is calculated and measured. Based on numerical simulations, the proposed coil is compared to traditional coil types. Moreover, the influential factors, such as the diameter and the intersection angle, are also analyzed. It was demonstrated that the proposed coil has a better performance in comparison with the figure-8 coil. Thus, this work suggests a new way to design stimulation coils for transcranial magnetic stimulation.


2013 ◽  
Vol 760-762 ◽  
pp. 2263-2266
Author(s):  
Kang Yong ◽  
Wei Chen

Beside the residual stresses and axial loads, other factors of pipe like ovality, moment could also bring a significant influence on pipe deformation under external pressure. The Standard of API-5C3 has discussed the influences of deformation caused by yield strength of pipe, pipe diameter and pipe thickness, but the factor of ovality degree is not included. Experiments and numerical simulations show that with the increasing of pipe ovality degree, the anti-deformation capability under external pressure will become lower, and ovality affecting the stability of pipe shape under external pressure is significant. So it could be a path to find out the mechanics relationship between ovality and pipe deformation under external pressure by the methods of numerical simulations and theoretical analysis.


Author(s):  
Zhengwei Ge ◽  
Chun Yang

Microfluidic concentration of sample species is achieved using the temperature gradient focusing (TGF) in a microchannel with a step change in the cross-section under a pure direct current (DC) field or a combined alternating current (AC) and DC electric field. Experiments were carried out to study the effects of applied voltage, buffer concentration and channel size on sample concentration in the TGF processes. These effects were analyzed and summarized using a dimensionless Joule number that is introduced in this study. In addition, Joule number effect in the Poly-dimethylsiloxane (PDMS)/PDMS microdevice was compared with the PDMS/Glass microdevice. A more than 450-fold concentration enhancement was obtained within 75 seconds in the PDMS/PDMS microdevice. Results also showed that the high frequency AC electric field which contributes to produce the temperature gradient and reduces the required DC voltage for the sample concentration. The lower DC voltage has generated slower electroosmotic flow (EOF), which reduces the backpressure effect associated with the finite reservoir size. Finally, a more than 2500-fold concentration enhancement was obtained within 14 minutes in the PDMS/PDMS microdevice, which was a great achievement in this TGF technique using inherent Joule heating effects.


Author(s):  
M. Akbari ◽  
M. Bahrami ◽  
D. Sinton

An optothermal analyte preconcentration method is introduced in this work based on temperature gradient focusing. The present approach offers a flexible, noncontact technique for focusing and transporting of analytes. Here, we use a commercial video projector and an optical system to generate heat and control the heat source position, size and power. This heater is used to focus a sample model analyte, fluorescent dye, at an arbitrary location along the microchannel. Optothermal manipulation of the focused band was demonstrated by projecting a series of images with a moving light band.


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