Recodification of the Civil Code of Ukraine and modernisation of the Civil Code of the Republic of Kazakhstan: A comparative analysis of the main ideas

Systematic updating of the civil legislation of Ukraine and modernisation of the civil legislation of the Republic of Kazakhstan are time-consuming tasks as evidenced by the analysis of changes that were made to the civil codes of Ukraine and the Republic of Kazakhstan and their law enforcement practice. Work on updating civil legislation requires an assessment of the current state and prospects of socio-economic development of Ukrainian society and the state, in particular the development of such an important component as the national legal system, which is presented in the concept of updating the Civil Code of Ukraine. It is crucial that the main areas of the concept orient the development of civil law in Ukraine, considering the current experience of recodification of civil codes of other states within the continental legal family. Considering that civil legislation is also being modernised in the Republic of Kazakhstan, the purpose of this study is to compare the main ideas of recodification of the Civil Code of Ukraine and modernisation of the Civil Code of the Republic of Kazakhstan to establish a systematic approach and a unified concept for the development of civil law and form a clear guideline for the improvement of civil legislation. The study analyses the areas of updating the civil legislation of Ukraine and the Republic of Kazakhstan based on both general (historical, comparative, system analysis) and special (specific-sociological, formal legal, legal-technical, etc.) methods. One of the most reasonable ways to ensure continuity of legal regulation of civil relations and ensure the modernisation of the legal basis for the development of the sphere of social and legal relations in the long term is the approach that should preserve all the achievements of existing civil codes, considering modern European approaches and the specific features of civil and business turnover

When to Start and Stop Bone-Protecting Medication for Preventing Glucocorticoid-Induced Osteoporosis

Glucocorticoid-induced osteoporosis (GIOP) leads to fractures in up to 40% of patients with chronic glucocorticoid (GC) therapy when left untreated. GCs rapidly increase fracture risk, and thus many patients with anticipated chronic GC exposures should start anti-osteoporosis pharmacotherapy to prevent fractures. In addition to low awareness of the need for anti-osteoporosis therapy among clinicians treating patients with GCs, a major barrier to prevention of fractures from GIOP is a lack of clear guideline recommendations on when to start and stop anti-osteoporosis treatment in patients with GC use. The aim of this narrative review is to summarize current evidence and provide considerations for the duration of anti-osteoporosis treatment in patients taking GCs based on pre-clinical, clinical, epidemiologic, and pharmacologic evidence. We review the pathophysiology of GIOP, outline current guideline recommendations on initiating and stopping anti-osteoporosis therapy for GIOP, and present considerations for the duration of anti-osteoporosis treatment based on existing evidence. In each section, we illustrate major points through a patient case example. Finally, we conclude with proposed areas for future research and emerging areas of interest related to GIOP clinical management.

Achieving Long Term Sustainability through Green Process Innovation: A Study on Small Packaging Companies in the UK

Packaging is increasingly considered as dominating environmental issue in the last two decades and has forced many global businesses to reconsider the true function of their packaging. Manufacturing flexibility and efficiency are considered highly competitive for industrial success. However, several packaging organizations are trying to see the packaging problem from the aspect of sustainability and in the 21st century, the word “green” and sustainability have become essential adjectives for the packaging industry. To maintain environmental impact and sustainability together, packaging has required clear directions to address challenges, while addressing environmental issues that result from packaging waste. Packaging operations for small firms is a costly and timely endeavour and there is no crystal-clear guideline for small firms to get the most from their existing processes. Green process innovation is seen as an efficient solution that can help society and businesses to deal with environmental problems but green process innovation popularity among researchers is not prominent. With having very little information on green process innovation this research considers various elements to bridge the sustainable framework. Based on the analysis this research identifies the key implementations and develops a framework of sustainable green process innovation. This research also discusses the limitations and provide greater insight on the implementation of green process innovation in the small packaging business.

Thrombosis associated with ventriculoatrial shunts

Ventriculoatrial shunts are the most common second-line procedure for cases in which ventriculoperitoneal shunts are unsuitable. Shunting-associated thrombosis is a potentially life-threatening complication after ventriculoatrial shunt insertion. The overall prevalence of this complication is still controversial because of substantial differences in the numbers found in studies using clinical data and in those analyzing postmortem findings. The etiology of thrombosis may be multifactorial, including shunt catheter itself, contents of cerebrospinal fluid, shunt infection, and genetic disorder. The clinical presentation can vary widely, ranging from asymptomatic to a life-threatening condition. Timely recognition of thromboembolic lesions is critical for treatment. However, early diagnosis and management is still challenging because of a relatively long asymptomatic latency and lack of clear guideline recommendations. The purpose of this review is to provide an overview of ventriculoatrial shunt thrombosis, especially to focus on its etiopathogenesis, diagnosis, treatment, and prevention.

Carcinosarcoma of the nasopharynx: a case report

<p>Carcinosarcoma is a malignant tumor with a dual histological appearance, a squamous epithelial (sarcomatous), and a mesenchymal component. Carcinosarcomas are characterized by a high recurrence rate, metastatic spread, and high morbidity and mortality. Carcinosarcoma can arise from any squamous epithelial lining but rare in the sino-nasal tract. We are presenting a case of a 19-year-old male with a 3-month history of recurrent epistaxis associated with nasal blockage, anosmia, and bilateral complete loss of vision over a few weeks. Carcinosarcoma of the sino-nasal tract is a rare entity and can mimic any sino-nasal malignancy. The optimal treatment of this disease is controversial and lacks a clear guideline, therefore challenging to the treating oncologists.<strong> </strong>Carcinosarcoma of the head and neck is a rare and aggressive tumor. It poses diagnostic and treatment challenges.</p>

X-linked hypophosphatemic rickets: Orthodontic considerations and management. A case report

X-linked hypophosphatemic rickets (XLH) is a rare condition affecting bone metabolism. It has characteristic dental features such as poorly mineralised dentine, spontaneous abscess formation in the absence of caries and taurodontism. There are limited published data about patients with this condition undergoing orthodontic treatment, and there is no clear guideline on the suitability of orthodontic treatment in this cohort. We present a case report of a patient with XLH with a confirmed PHEX gene mutation undergoing orthodontic treatment and clinical recommendations to support treatment.

BRAND CRISIS RESPONSE STRATEGIES: A TYPOLOGIES CONTINUUM

This purpose of this study is to provide a spectrum to illustrate all applicable response strategies towards brand crisis management. A qualitative systematic method is adopted to review 128 relevant papers and synthesized in a brand crisis response typologies continuum. The findings were illustrated in the continuum which includes two main categories – primary response group with seven levels ranked lowest to highest by organizational involvement and responsibility, and secondary response group such as bolstering). This research result might enrich the current literature of brand crisis management which is fragmented and provide a clear guideline so that scholars and practitioners might track all pertinent solutions depending on low to high level of brands’ effort towards handling problems. Recognizing the discrepancy among response strategies, marketers and branders can choose either singular or merged solutions shown in the map to form a timely response to brand crisis, which is the main factor to crisis response success.

Over-prescription of short-acting beta agonists in the treatment of asthma

Background Despite a clear guideline for asthma medication, excessive use of short-acting β2-agonists (SABAs) is common in clinical practice. Previous research has shown that excessive use of SABAs is associated with poor asthma control. Objective This study examines current use of asthma medication in primary care and whether excessive use of SABAs is associated with exacerbations. Methods The study design was a retrospective analysis using information from electronical medical records from patients aged 18 and older of five Julius Health Centers located in Utrecht, the Netherlands, in the period of 1 July 2018 through 1 July 2019. Excessive SABA use was defined as ≥400 inhalations per year. An exacerbation was defined as an acute worsening of asthma symptoms with the need for systemic corticosteroids. Results A total of 1161 patients were included in the study. Of the patients using SABAs (n = 766), 193 (25%) overused SABAs. Among the patients with inappropriate SABA use (n = 193), 19% had an exacerbation compared with 7% of the appropriate SABA users. For patients using asthma medication the odds of having an exacerbation were 2.9 times higher if they used an inappropriate number of SABAs than if SABAs were used appropriately (odds ratio, 2.897; 95% confidence interval, 1.87–4.48). Conclusions This study shows that overuse of SABAs is still common and that it is associated with asthma exacerbations. It highlights that clinicians need to be aware of inappropriate SABA use as it is a sign of and can even contribute to poor asthma control.

Improved SAR Altimetry Techniques in Coastal Island Areas

&lt;p&gt;Improved SAR Altimetry Techniques in Coastal Island Areas&lt;/p&gt;&lt;p&gt;Synthetic Aperture Radar (SAR) Altimetry has made a remarkable progress over the past years. Advances in data processing, combined with technological progress such as the advent of new Altimetry satellites (Sentinel 3A,3B,6, SWOT etc.) increased the accuracy of the retrieved geophysical parameters (i.e., Sea Level Anomaly, Significant Wave Height and Wind Speed) in coastal zones within several hundred meters from the coastline.&lt;/p&gt;&lt;p&gt;The improvement in the estimation of the geophysical parameters using SAR Altimetry has been reported by many researchers. The improved accuracy is obtained through the development of new SAR Altimetry retracking algorithms in several research and development projects (i.e., SAR Altimetry Mode Studies and Applications-SAMOSA). &amp;#160;Similar to Low Resolution Mode (LRM) Altimetry, the requirement of specialized retrackers for SAR waveforms is vital in improving the estimated ocean parameters. The waveform retracking is a postprocessing protocol to convert waveforms into scientific parameters of power amplitude (related to wind speed), range (related to sea level), and slope of leading edge (related to SWH) that characterize the observed scene (Idris et al., 2021).&lt;/p&gt;&lt;p&gt;However, several issues remain open. Close to the coastline, SAR altimeter simultaneously views scattering surfaces of both water and land producing complicated waveform patterns therefore a huge range of waveform shapes is observed. This complexity poses a real challenge to today&amp;#8217;s approach to retrack waveform.&lt;/p&gt;&lt;p&gt;The combination of different retracking algorithms is essential for dealing with this high diversity of altimetric waveform patterns since there is no single retracker that can retrack all of them. However, this raises two significant issues. The first is regarding to the selection of the optimal retracker under various conditions. The lack of a clear guideline on the selection criteria of the optimal retracker limits the use of this combining method. The second is how to reduce the offset caused by switching retrackers, as it results in relative offsets in altimeter-derived SLAs. This offset is partly caused by the retracking method itself, in which the fitting algorithms are affected by noise in the trailing edge due to the SWHs variability (Idris et al., 2018).&lt;/p&gt;&lt;p&gt;Due to the issues in coastal Altimetry data the focus of this work is:&lt;/p&gt;&lt;ul&gt;&lt;li&gt;1) To improve the sea measurements from the SAR Altimetry missions by developing a new retracking algorithm taking advantage artificial intelligence and machine learning technologies.&lt;/li&gt; &lt;/ul&gt;&lt;p&gt;&amp;#160;&lt;/p&gt;&lt;ul&gt;&lt;li&gt;2) To further investigate the assessment of the offset between various retrackers and the use of a neural network for reducing the offset in the retracked SLAs by including information about SWH.&lt;/li&gt; &lt;/ul&gt;&lt;p&gt;&amp;#160;&lt;/p&gt;&lt;ul&gt;&lt;li&gt;3) To validate the altimeter derived SLAs by performing tests and comparisons with data from many island coastal areas worldwide.&lt;/li&gt; &lt;/ul&gt;&lt;p&gt;Also, this work aims to improve the Sea State Bias corrections (SSB), which is currently one of the range corrections with the largest uncertainty in the coastal zone (Vignudelli et al., 2019), by providing more accurate sea measurements near the coast.&lt;/p&gt;

A review of endovascular treatment for medium vessel occlusion stroke

Medium-vessel occlusions (MeVOs), that is, occlusions of the M2/3 middle cerebral artery, A2/3 anterior cerebral artery, and P2/3 posterior cerebral artery segments, account for 25%–40% of all acute ischemic stroke cases. Clinical outcomes of MeVO stroke with intravenous thrombolysis, which is the current standard of care, are moderate at best. With improving imaging technologies and a growing literature, MeVOs are increasingly recognized as a target for endovascular treatment (EVT). For the time being, there is limited but promising evidence for the safety and efficacy of MeVO EVT, and many neurointerventionists are already routinely offering EVT for MeVO stroke, despite the lack of clear guideline recommendations. In this article, we review the evidence on endovascular treatment for MeVO stroke and summarize the available literature on current imaging strategies, commonly used EVT selection criteria, EVT techniques, and outcome assessment for MeVO stroke.