Microcantilever Based Microdiagnostic Kit for Biomedical Applications: A Cost-Benefit Outlook

2010 ◽  
Vol 1 (3) ◽  
Author(s):  
Sree Vidhya ◽  
Gideon Praveen Kumar ◽  
Lazar Mathew
Keyword(s):  
Stainless Steel ◽  
Dna Hybridization ◽  
Biomedical Applications ◽  
Microelectromechanical Systems ◽  
Systems Design ◽  
Cost Benefit ◽  
Antigen Binding ◽  
Important Principle ◽  
Geometric Variation ◽  
Simulation Package

Piezoresistive actuation of a microcantilever induced by biomolecular binding such as DNA hybridization and antibody-antigen binding is an important principle useful in biosensing applications. As the magnitude of the forces exerted is small, increasing the sensitivity of the microcantilever becomes critical. In this paper, we are considering to achieve this by geometric variation of the cantilever. The sensitivity of the cantilever was improved so that the device can sense the presence of the antigen even if the magnitude of surface stresses over the microcantilever was very small. We consider a “T-shaped” cantilever that eliminates the disadvantages while improving the sensitivity simultaneously. An analysis of the cantilever using stainless steel and silicon has been performed using INTELLISUITE software (a microelectromechanical systems design and simulation package).

Design and TEM Simulation of a MEMS Based Microcantilever Cardiac Marker Sensor

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Sree Vidhya ◽  
Gideon Praveen Kumar ◽  
Lazar Mathew
Keyword(s):  
System Design ◽  
Dna Hybridization ◽  
Electromechanical System ◽  
Antigen Binding ◽  
Cardiac Marker ◽  
Important Principle ◽  
Micro Electromechanical System ◽  
Geometric Variation ◽  
Proportional Decrease ◽  
Simulation Package

Piezoresistive actuation of a microcantilever induced by biomolecular binding such as DNA hybridization and antibody-antigen binding is an important principle useful in biosensing applications. As the magnitude of the forces exerted is small, increasing the sensitivity of the microcantilever becomes critical. In this paper, we are considering to achieve this by geometric variation in the cantilever. The sensitivity of the cantilever was improved so that the device can sense the presence of antigen even if the magnitude of surface-stresses over the microcantilever was very small. We consider a “T-shaped” cantilever that eliminates the disadvantages while improving the sensitivity simultaneously. Simulations for validation have been performed using INTELLISUITE software (a micro-electromechanical system design and simulation package). The simulations reveal that the T-shaped microcantilever is almost as sensitive as a thin cantilever and has relatively very low buckling effect. Simulations also reveal that with an increase in thickness of the cantilever, there is a proportional decrease in the sensitivity.

scholarly journals Electric Field-Assisted Orientation of Short Phosphate Glass Fibers on Stainless Steel for Biomedical Applications

2018 ◽  
Vol 10 (14) ◽  
pp. 11529-11538 ◽  
Author(s):  
Qiang Chen ◽  
Jiajia Jing ◽  
Hongfei Qi ◽  
Ifty Ahmed ◽  
Haiou Yang ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Electric Field ◽  
Phosphate Glass ◽  
Biomedical Applications ◽  
Glass Fibers

scholarly journals Fabrication and Characterization of Zein/Hydroxyapatite Composite Coatings for Biomedical Applications

Surfaces ◽  
2020 ◽  
Vol 3 (2) ◽  
pp. 237-250 ◽  
Author(s):  
Yusra Ahmed ◽  
Muhammad Yasir ◽  
Muhammad Atiq Ur Rehman
Keyword(s):  
Stainless Steel ◽  
Corrosion Resistance ◽  
Biomedical Applications ◽  
Steel Substrate ◽  
Composite Coatings ◽  
Sem Images ◽  
Taguchi Design Of Experiments ◽  
Hydrophilic Nature ◽  
Strong Adhesion ◽  
Steel Substrates

Stainless steel is renowned for its wide use as a biomaterial, but its relatively high corrosion rate in physiological environments restricts many of its clinical applications. To overcome the corrosion resistance of stainless steel bio-implants in physiological environments and to improve its osseointegration behavior, we have developed a unique zein/hydroxyapatite (HA) composite coating on a stainless steel substrate by Electrophoretic Deposition (EPD). The EPD parameters were optimized using the Taguchi Design of experiments (DoE) approach. The EPD parameters, such as the concentration of bio-ceramic particles in the polymer solution, applied voltage and deposition time were optimized on stainless steel substrates by applying a mixed design orthogonal Taguchi array. The coatings were characterized by using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and wettability studies. SEM images and EDX results indicated that the zein/HA coating was successfully deposited onto the stainless steel substrates. The wettability and roughness studies elucidated the mildly hydrophilic nature of the zein/HA coatings, which confirmed the suitability of the developed coatings for biomedical applications. Zein/HA coatings improved the corrosion resistance of bare 316L stainless steel. Moreover, zein/HA coatings showed strong adhesion with the 316L SS substrate for biomedical applications. Zein/HA developed dense HA crystals upon immersion in simulated body fluid, which confirmed the bone binding ability of the coatings. Thus the zein/HA coatings presented in this study have a strong potential to be considered for orthopedic applications.

scholarly journals Silicon-Based Sensors for Biomedical Applications: A Review

Sensors ◽  
2019 ◽  
Vol 19 (13) ◽  
pp. 2908 ◽  
Author(s):  
Yongzhao Xu ◽  
Xiduo Hu ◽  
Sudip Kundu ◽  
Anindya Nag ◽  
Nasrin Afsarimanesh ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Microelectromechanical Systems ◽  
Human Life ◽  
Market Survey ◽  
Biomedical Sensing ◽  
Silicon Sensors ◽  
Mems Technology ◽  
Current Scenario ◽  
Silicon Based

The paper highlights some of the significant works done in the field of medical and biomedical sensing using silicon-based technology. The use of silicon sensors is one of the pivotal and prolonged techniques employed in a range of healthcare, industrial and environmental applications by virtue of its distinct advantages over other counterparts in Microelectromechanical systems (MEMS) technology. Among them, the sensors for biomedical applications are one of the most significant ones, which not only assist in improving the quality of human life but also help in the field of microfabrication by imparting knowledge about how to develop enhanced multifunctional sensing prototypes. The paper emphasises the use of silicon, in different forms, to fabricate electrodes and substrates for the sensors that are to be used for biomedical sensing. The electrical conductivity and the mechanical flexibility of silicon vary to a large extent depending on its use in developing prototypes. The article also explains some of the bottlenecks that need to be dealt with in the current scenario, along with some possible remedies. Finally, a brief market survey is given to estimate a probable increase in the usage of silicon in developing a variety of biomedical prototypes in the upcoming years.

Electrophoretic Deposition of PEEK-TiO2 Composite Coatings on Stainless Steel

2012 ◽  
Vol 507 ◽  
pp. 127-133 ◽  
Author(s):  
Sigrid Seuss ◽  
Tayyab Subhani ◽  
Min Yi Kang ◽  
Kenji Okudaira ◽  
Isaac E. Aguilar Ventura ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Stainless Steel ◽  
Electrophoretic Deposition ◽  
Biomedical Applications ◽  
316L Stainless Steel ◽  
Treatment Process ◽  
Composite Coatings ◽  
Heat Treatment Process ◽  
Steel Substrates ◽  
Scanning Electron

Electrophoretic deposition (EPD) has been successfully used to deposit composite coatings composed of polyetheretherketone (PEEK) and titanium dioxide (TiO2) nanoparticles on 316L stainless steel substrates. The suspensions of TiO2 nanoparticles and PEEK microparticles for EPD were prepared in ethanol. PEEK-TiO2 composite coatings were optimized using suspensions containing 6wt% PEEK-TiO2 in ethanol with a 3:1 ratio of PEEK to TiO2 in weight and by applying a potential difference of 30 V for 1 minute. A heat-treatment process of the optimized PEEK-TiO2 composite coatings was performed at 335°C for 30 minutes with a heating rate of 10°Cminto densify the deposits. The EPD coatings were microstructurally evaluated by scanning electron microscopy (SEM). It was demonstrated that EPD is a convenient and rapid method to fabricate PEEK/TiO2 coatings on stainless steel which are interesting for biomedical applications.

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