scholarly journals Molecular Imprinted Polymer for a Purfication Device

2009 ◽  
Vol 3 (2) ◽  
Author(s):  
A. A. Bawazir ◽  
B. D. Moore ◽  
J. D. S. Gaylor
Keyword(s):  
Molecular Imprinting ◽  
Protein Extraction ◽  
Protein Denaturation ◽  
Solid Phase ◽  
Polymer Network ◽  
Medical Diagnostics ◽  
Aprotic Solvents ◽  
Imprinted Polymer ◽  
Nanostructured Particles ◽  
Biological Recognition

Molecular imprinting is a well established technology that mimics biological recognition systems using artificial materials. This involves synthesizing a nanostructured polymeric host in the presence of a target molecule to generate complementary binding sites that are selective for a molecule of interest. The technique offers a platform for developing simple and inexpensive systems with a vast array of applications such as; chromatography, separation, catalysts purification, solid phase extraction, biosensors, medical diagnostics and drug delivery. Elevated levels of some proteins in the blood can lead to a number of medical conditions. Incorporating these polymers into a device for blood purification to remove such molecules can be used as a means to combat these problems. Protein imprinting was studied from a novel perspective using protein coated micro crystals (PCMCs). PCMCs are nanostructured particles made via a rapid 1-step process developed by Moore et al. (2001). The use of a novel PCMCs strategy in molecular imprinting has allowed the retention of selected protein native conformation in organic media and the creation of access pores lined with nanocavities which facilitate protein extraction and re-introduction into the imprinted polymer. This technique has enabled us to overcome many of the challenges faced when using conventional imprinting methodology, such as protein insolubility in aprotic solvents, protein insolubility in aprotic solvents, protein denaturation and aggregation as a result of polymerization conditions and the permanent entrapment of the protein template in the cross linked polymer network.

Stoichiometric molecular imprinting using polymerisable urea and squaramide receptors for the solid phase extraction of organo-arsenic compound roxarsone

2020 ◽  
Vol 12 (47) ◽  
pp. 5729-5736
Author(s):  
Simone Cavalera ◽  
Fabio Di Nardo ◽  
Giulia Spano ◽  
Laura Anfossi ◽  
Panagiotis Manesiotis ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Molecular Imprinting ◽  
Surface Waters ◽  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Phase Extraction ◽  
Functional Monomer ◽  
Arsenic Compound ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

A selective molecularly imprinted polymer prepared with a squaramide-based functional monomer was used for the solid phase extraction of roxarsone from surface waters.

scholarly journals Selective Enrichment of Clenbuterol onto Molecularly Imprinted Polymer Microspheres with Tailor-made Structure and Oxygen Functionalities

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1635 ◽  
Author(s):  
Xiangyun Zhao ◽  
Yuliang Mai ◽  
Dongchu Chen ◽  
Min Zhang ◽  
Huawen Hu
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Photoelectron Spectroscopy ◽  
Solid Phase ◽  
Feed Additive ◽  
Extraction Column ◽  
Polymer Microspheres ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Selective Enrichment

The noxious clenbuterol misapplied as the feed additive has posed an enormous threat to humans who actively rely on the food chains with high potential of contamination by clenbuterol, such as pork and beef. It is, therefore, highly desirable to develop novel materials and strategies for dealing with the clenbuterol. Herein, functional polymer microspheres prepared by Pickering emulsion polymerization were explored for the selective enrichment of the clenbuterol, and their structure and oxygen functionalities could be tailor-made by a molecular imprinting process. The clenbuterol imprinting was adequately demonstrated to not only increase the particle size (~52 nm vs. ~42 nm) and create cavities for the accommodation of the clenbuterol molecules, but also reduce the oxygen functionalities of the resulting molecularly imprinted polymer microspheres (MIPMs) by approximately 4 at.%, which is believed to correlate with the high specificity of the MIPMs. Various characterization methods were employed to evidence these findings, including scanning electron microscopy, BET measurements, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and elemental mapping examination. More importantly, the MIPMs showed a markedly superior enrichment capability towards clenbuterol to the counterpart, that is, non-molecularly imprinted polymer microspheres (NIPMs). Compared to the NIPMs without specificity for clenbuterol, the MIPMs exhibited an impressive selectivity to clenbuterol, with the relative selectivity coefficient (k′) values largely exceeding 1, thus corroborating that the useful molecular imprinting led to the generation of the binding sites complementary to the clenbuterol molecule in the size and functionalities. The MIPMs were also employed as the stationary phase to fabricate molecularly imprinting solid-phase extraction column, and the spike recovery was demonstrated to be not significantly decreased even after nine cycles. Furthermore, the reliability of the method was also evidenced through the comparison of the MIPMs prepared from different batches.

Synthesis and characterization of an ion-imprinted polymer for selective solid phase extraction of thorium(IV)

2011 ◽  
Vol 173 (3-4) ◽  
pp. 423-431 ◽  
Author(s):  
Zhiqiang Cheng ◽  
Hongqing Wang ◽  
Yuyuan Wang ◽  
Fangfang He ◽  
Haisheng Zhang ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Synthesis And Characterization ◽  
Phase Extraction ◽  
Ion Imprinted Polymer ◽  
Imprinted Polymer ◽  
Ion Imprinted
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