Arsenic compound sensitizes homologous recombination proficient ovarian cancer to PARP inhibitors

The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors show survival benefits in ovarian cancer patients with BRCA1/2 mutation or homologous recombination (HR) deficiency, but only limited efficacy in HR-proficient ones. Another drug, arsenic trioxide (ATO) or arsenic drug (RIF), exerts antitumor effects via inducing DNA damage. Here, we investigated the combined therapeutic effects of the PARP inhibitors and the arsenic compound in HR-proficient ovarian cancer. The combined treatment of niraparib, olaparib, or fluazolepali with ATO showed a significant suppression in tumor cell viability and colony formation. The drug treatment also induced synergistic inhibition of cell proliferation and DNA damage, and acceleration of cell apoptosis in two HR-proficient ovarian cancer cell lines SKOV3 and CAOV3, either by simultaneous or sequential administration. The mechanism underlying these synergistic effects were reflected by the significantly increased ratio of cleaved-PARP/total PARP and decreased ratio of p-AKT/total AKT. Consistently, the combination of olaparib with RIF synergistically reduced the tumor growth in mouse xenograft models. In conclusion, the arsenic compound greatly sensitizes HR-proficient ovarian cancer cells to the PARP inhibitors, and our findings provide an evidence for the clinical treatment development of this combination in HR-proficient ovarian cancer patients.

Stoichiometric molecular imprinting using polymerisable urea and squaramide receptors for the solid phase extraction of organo-arsenic compound roxarsone

A selective molecularly imprinted polymer prepared with a squaramide-based functional monomer was used for the solid phase extraction of roxarsone from surface waters.

Design and Development of Mach Zehnder Interferometer based Optical Sensors to Detection of Arsenic compound in Drinking Water

Water, the inevitable need of any individual, must be monitored. Detection of the arsenic chemical present in water leads to contagious diseases. The legacy makes people difficult to survive. The consequences are cancer, other diseases. Employing photonic crystal waveguide with the rally round of mach Zehnder interferometer, it is feasible to correctly compute arsenic compound level in water. MZI sensor has many compensation, diminutive, least use of instrumentation, and ready to be used with CMOS technology. Follows in the paper, arsenic compound level of wavelength range of 1530–1565 nm is analyzed and detected. Experiential program from the band arrangement that for minute change in refractive index is accounted, subsequently logical shift in the frequency and amplitude will be evident enlarging mach Zehnder interferometer will behave as a sensor. Thus projected alternate included optical Mach Zehnder Interferometer (MZI), composed of graded index channel waveguide that can be frequently used as chemical and biological sensor in this manuscript. This dissertation describes how the MZI operates two arms predominantly to conquer the industrial challenges. Manuscript represents test data, graph and results that exemplify the performance of whole system.